Results 91 to 100 of about 697,969 (251)

Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System

open access: yesFrontiers in Immunology, 2022
Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients.
Michal Magda   +6 more
doaj   +1 more source

Expression and Immunogenicity Analysis of Recombinant Leptospira Interrogans Surface Protein LigA in Mouse Model

open access: yesVeterinary Medicine and Science, Volume 11, Issue 3, May 2025.
Implemented strategies in designing, production, purification and immunogenicity of the recombinant Leptospiral immunoglobulin‐like surface protein‐A (r‐Lig A) as a vaccine candidate. ABSTRACT Background Pathogenic strains of spirochetes of Leptospira spp. cause a globally distributed zoonotic disease called leptospirosis.
Aida Chalesh   +4 more
wiley   +1 more source

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients. [PDF]

open access: yesPLoS ONE, 2014
BackgroundNon-tuberculous mycobacteria (NTM) are ubiquitous in the environment and they infect mainly persons with underlying pulmonary diseases but also previously healthy elderly women.
Hannele Kotilainen   +9 more
doaj   +1 more source

Decidability of Existence and Construction of a Complement of a given Function [PDF]

open access: yesarXiv, 2011
This article defines a complement of a function and conditions for existence of such a complement function and presents few algorithms to construct a complement.
arxiv  

Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
A new CdCS rat model is developed using CRISPR‐Cas9 technology. It shows impairments in cognitive and social behaviors, neuronal dendrite abnormalities in the hippocampus and mPFC, and inflammatory and immune processes in mPFC brain cells. Early AAV‐Ctnnd2 gene therapy enhances cognitive function in CdCS rats.
Jingjing Shen   +11 more
wiley   +1 more source

Complemented subspaces of products of Banach spaces [PDF]

open access: yesarXiv, 2000
We show that complemented subspaces of uncountable products of Banach spaces are products of complemented subspaces of countable subproducts.
arxiv  

Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors

open access: yesAlzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract BACKGROUND Cerebral amyloid angiopathy (CAA) is a hallmark of Alzheimer's disease (AD), linked to adverse effects of emerging AD treatments. We explored the molecular effects of CAA in mouse brain and evaluated how these could be prevented by two repurposed United States Food and Drug Administration (FDA) approved treatments.
Jasper Carlsen   +4 more
wiley   +1 more source

The Proteomic Landscape of the Coronary Accessible Heart Cell Surfaceome

open access: yesPROTEOMICS, Volume 25, Issue 7, April 2025.
ABSTRACT Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling and cellular phenotyping in physiological and pathological states. Here, we employed coronary artery perfusion with membrane‐impermeant biotin to label and capture the surface‐accessible proteome in the neo ...
Iasmin Inocencio   +3 more
wiley   +1 more source

On the complemented subspaces of X_p [PDF]

open access: yesarXiv, 1990
In this paper we prove some results related to the problem of isomorphically classifying the complemented subspaces of $X_{p}$. We characterize the complemented subspaces of $X_{p}$ which are isomorphic to $X_{p}$ by showing that such a space must contain a canonical complemented subspace isomorphic to $X_{p}.$ We also give some characterizations of ...
arxiv  

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study

open access: yesClinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Avner Sandhu   +8 more
wiley   +1 more source

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