Results 11 to 20 of about 697,969 (251)

A case report of complement C4B deficiency in a patient with steroid and IVIG-refractory anti-NMDA receptor encephalitis. [PDF]

BMC Neurol, 2020
Background Complement C4A or C4B deficiency has never been reported in autoantibody-associated encephalitides patient. Here we present a case of anti-N-methyl- D-aspartate (NMDA) receptor encephalitis associated with homozygous C4B deficiency, who did ...
Chua GT, Zhou D, Ho ACC, Chan SHS, Yu CY, Lau YL.   +5 more
europepmc   +3 more sources

Real-time PCR quantification of human complement C4A and C4B genes [PDF]

BMC Genetics, 2006
AbstractBackgroundThe fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome. Although these genes differ only in 5 nucleotides, the encoded C4A and C4B proteins are functionally different.
Zsolt Ronai, George Füst, Maria Sasvari-Szekely, Denes Szilassy, Ágnes Szilágyi, Bernadett Blaskó   +5 more
doaj   +7 more sources

Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis [PDF]

BMC Infectious Diseases, 2014
AbstractBackgroundMycobacterium tuberculosisinfection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation.MethodsClinical data of 187 cases of pulmonary tuberculosis (PTB) were analyzed using statistical methods, while serum levels of complement C4b (C4b),
Xiuyun Yang, Tingting Jiang, Li-Liang Wei, Yanyuan Li, Zhong-Liang Chen, Zhong-Jie Li, Ze-Peng Ping, Dandan Xu, Ji-Cheng Li, Xiang Li, Xing Zhang, Jiyan Liu, Chong Wang   +12 more
europepmc   +5 more sources

Clinical features of patients with homozygous complement C4A or C4B deficiency

PLOS ONE, 2018
Homozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex. There are no studies where the clinical presentation of these patients is analyzed.
Inka Liesmaa, Riitta Paakkanen, Asko Järvinen, Ville Valtonen, Marja-Liisa Lokki   +4 more
doaj   +7 more sources

Human Pentraxin 3 Binds to the Complement Regulator C4b-Binding Protein [PDF]

PLoS ONE, 2011
The long pentraxin 3 (PTX3) is a soluble recognition molecule with multiple functions including innate immune defense against certain microbes and the clearance of apoptotic cells. PTX3 interacts with recognition molecules of the classical and lectin complement pathways and thus initiates complement activation.
Anne Braunschweig, Mihály Józsi
doaj   +6 more sources

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface. [PDF]

Infect Immun, 2019
Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked. ABSTRACT Complement is a critical component of antimicrobial immunity.
Haleem KS, Ali YM, Yesilkaya H, Kohler T, Hammerschmidt S, Andrew PW, Schwaeble WJ, Lynch NJ.   +7 more
europepmc   +2 more sources

Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE)

Lupus Science and Medicine, 2019
Objective Systemic lupus erythematosus (SLE) features high frequency of cardiovascular disease (CVD) and fluctuating complement levels. The clinical trial Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) aimed to evaluate whether ...
Evan Mulvihill, Stacy Ardoin, Susan D Thompson, Bi Zhou, Gakit Richard Yu, Emily King, Nora Singer, D M Levy, Hermine Brunner, Yee Ling Wu, Haikady N Nagaraja, Laura Eve Schanberg, Chack-Yung Yu   +12 more
doaj   +2 more sources

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1990
The C4B isotype of the fourth component of human complement (C4) displays 3- to 4-fold greater hemolytic activity than does its other isotype C4A.
M. Carroll, Dehmanhi M. Fathallah, L. Bergamaschini, E. Alicot, D. Isenman   +4 more
semanticscholar   +2 more sources

Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes.

Journal of Biological Chemistry, 1990
C4b-binding protein (C4BP) is a large complex assembly of eight subunits that functions as an inhibitor of the complement cascade. A portion of the C4BP in serum exists as a complex with protein S. This study demonstrated that another protein, serum amyloid P component (SAP), also formed a calcium-dependent complex with C4BP.
Gary L. Nelsestuen, Björn Dahlbäck, Ruth A. Schwalbe   +2 more
openaire   +4 more sources

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities [PDF]

Frontiers in Immunology, 2018
The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
C. Hertz, R. Bayarri-Olmos, Nikolaj Kirketerp-Møller, S. V. van Putten, Katrine Pilely, M. Skjoedt, P. Garred   +6 more
semanticscholar   +2 more sources