Real-time PCR quantification of human complement C4A and C4B genes [PDF]
BMC Genetics, 2006 Background The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome.
Fust George +5 more
doaj +5 more sources
Increased frequency of complement C4B deficiency in rheumatoid arthritis. [PDF]
Arthritis Rheum, 2012 AbstractObjectiveTo assess the copy number variation of complement C4A and C4B genes in patients with rheumatoid arthritis (RA).MethodsDNA samples were obtained from 299 patients and controls and analyzed for copy number variation of total complement C4, C4A, and C4B genes. The results were compared by chi‐square analysis, and odds ratios (ORs) and 95%
Rigby WF +7 more
europepmc +5 more sources
Clinical features of patients with homozygous complement C4A or C4B deficiency.
PLoS ONE, 2018 IntroductionHomozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex.
Inka Liesmaa +4 more
doaj +5 more sources
Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance IgM antibodies protect mammals against humoral microbial infection and mediate clearance of cellular debris. IgM activates the immune complement system only after binding to cell-surface antigens.
Thomas H. Sharp +5 more
openalex +2 more sources
Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein [PDF]
Viruses, 2023 The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection.
Nazar Beirag +9 more
openalex +2 more sources
Interaction between Protein S and Complement C4b-binding Protein (C4BP) [PDF]
Journal of Biological Chemistry, 1999 Human C4b-binding protein (C4BP) is a regulator of the complement system and plays an important role in the regulation of the anticoagulant protein C pathway.
R. H. van de Poel, J. Meijers, B. Bouma
semanticscholar +2 more sources
Human pentraxin 3 binds to the complement regulator c4b-binding protein. [PDF]
PLoS ONE, 2011 The long pentraxin 3 (PTX3) is a soluble recognition molecule with multiple functions including innate immune defense against certain microbes and the clearance of apoptotic cells.
Anne Braunschweig, Mihály Józsi
doaj +4 more sources
Borrelia burgdorferiouter surface protein C (OspC) binds complement component C4b and confers bloodstream survival [PDF]
Cellular Microbiology, 2017 Borrelia burgdorferi (Bb) is the causative agent of Lyme disease in the United States, a disease that can result in carditis, and chronic and debilitating arthritis and/or neurologic symptoms if left untreated.
Jennifer A. Caine +5 more
openalex +2 more sources
Impact of complement system proteins on the clinical progression of hospitalized patients with COVID-19 [PDF]
BMC Infectious DiseasesBackground The complement system is an important defense mechanism against pathogens, including viruses. In COVID-19, evidence suggests that hyperactivation of the complement system can lead to tissue damage and provoke dysregulation of the coagulation ...
Lorena Viana de Andrade +5 more
doaj +2 more sources
Functional recruitment of human complement inhibitor C4B-binding protein to outer membrane protein Rck of Salmonella. [PDF]
PLoS ONE, 2011 Resistance to complement mediated killing, or serum resistance, is a common trait of pathogenic bacteria. Rck is a 17 kDa outer membrane protein encoded on the virulence plasmid of Salmonella enterica serovars Typhimurium and Enteritidis.
Derek K Ho +5 more
doaj +6 more sources