Results 21 to 30 of about 712,823 (260)

Proteomic and In Silico Analyses Highlight Complement System’s Role in Bladder Cancer Immune Regulation [PDF]

Medicina
Background and Objectives: Bladder cancer (BLCA), intimately associated with the immune system, represents a substantial global health burden due to its high recurrence rates and limited therapeutic effectiveness.
Tuğcan Korak, İbrahim Halil Baloğlu, Murat Kasap, Elif Damla Arisan, Gurler Akpinar, Serdar Arisan   +5 more
doaj   +2 more sources

Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes [PDF]

Arthritis &Rheumatology, Accepted Article.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López, Carlos Rangel‐Peláez, Inmaculada Rodriguez‐Martin, Alfredo Guillén-Del-Castillo, Carmen Pilar Simeón‐Aznar, José Luís Callejas-Rubio, Anastasiia Kozlova, Susanna Proudman, Mandana Nikpour, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K de Vries‐Bouwstra, Ariane L. Herrick, Yannick Allanore, Marta E. Alarcón‐Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P. Denton, Maureen D. Mayes, Javier Martín, Marialbert Acosta‐Herrera, Martin Kerick, Martin Kerick   +22 more
openalex   +2 more sources

Significance of urine complement proteins in monitoring lupus activity [PDF]

PeerJ, 2022
Objectives Complement activation is a critical feature in the development of systemic lupus erythematosus (SLE). Whether there are changes of complement components in the urine of SLE has not been reported.
Jin Zhao, Jun Jiang, Yuhua Wang, Dan Liu, Tao Li, Man Zhang   +5 more
doaj   +2 more sources

Structure-Based Modeling of Complement C4 Mediated Neutralization of Adenovirus

Viruses, 2021
Adenovirus (AdV) infection elicits a strong immune response with the production of neutralizing antibodies and opsonization by complement and coagulation factors.
Corey C. Emerson, Phoebe L. Stewart
doaj   +1 more source

Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes.

Journal of Biological Chemistry, 1990
C4b-binding protein (C4BP) is a large complex assembly of eight subunits that functions as an inhibitor of the complement cascade. A portion of the C4BP in serum exists as a complex with protein S. This study demonstrated that another protein, serum amyloid P component (SAP), also formed a calcium-dependent complex with C4BP.
R. A. Schwalbe, B. Dahlbäck, G. Nelsestuen   +2 more
semanticscholar   +3 more sources

Complement C4b-Binding Protein as a Novel Murine Epididymal Secretory Protein [PDF]

Biology of Reproduction, 2003
Complement C4b-binding protein (C4BP) is a plasma protein synthesized in the liver and plays a regulatory role in the host defense complement system. We have previously reported that mRNAs of the C4BP alpha chain (C4BPalpha) are expressed at significant levels in the guinea pig and mouse epididymis in an androgen-dependent manner.
M. Nonaka, Y. Hishikawa, N. Moriyama, T. Koji, R. Ogata, A. Kudo, H. Kawakami, M. Nonaka   +7 more
semanticscholar   +3 more sources

Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes

Frontiers in Cellular Neuroscience, 2023
Complement system plays an important role in the immune defense against pathogens; however, recent studies demonstrated an important role of complement subunits C1q, C4, and C3 in normal functions of the central nervous system (CNS) such as non ...
Tatyana Veremeyko, Tatyana Veremeyko, Tatyana Veremeyko, Rongcai Jiang, Rongcai Jiang, Mingliang He, Eugene D. Ponomarev, Eugene D. Ponomarev, Eugene D. Ponomarev   +8 more
doaj   +1 more source

Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia. [PDF]

PLoS ONE, 2012
Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis.
Sven Malm, Monika Jusko, Sigrun Eick, Jan Potempa, Kristian Riesbeck, Anna M Blom   +5 more
doaj   +1 more source

Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP. [PDF]

Mol Cell Proteomics
C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalently bind vitamin K-dependent protein S (ProS). These spider-like structures can form even larger complexes as C4BP interacts with other, mostly complement ...
Kadavá T, Strasser J, Marefat M, Yin VC, Preiner J, Trouw LA, Heck AJR.   +6 more
europepmc   +3 more sources

Synovial Complement Factors in Patients with Periprosthetic Joint Infection after Undergoing Revision Arthroplasty of the Hip or Knee Joint

Diagnostics, 2021
The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by ...
Frank Sebastian Fröschen, Sophia Schell, Matthias Dominik Wimmer, Gunnar Thorben Rembert Hischebeth, Hendrik Kohlhof, Sascha Gravius, Thomas Martin Randau   +6 more
doaj   +1 more source