Results 21 to 30 of about 697,969 (251)

Complement C4b-Binding Protein as a Novel Murine Epididymal Secretory Protein [PDF]

Biology of Reproduction, 2003
Complement C4b-binding protein (C4BP) is a plasma protein synthesized in the liver and plays a regulatory role in the host defense complement system. We have previously reported that mRNAs of the C4BP alpha chain (C4BPalpha) are expressed at significant levels in the guinea pig and mouse epididymis in an androgen-dependent manner.
Mayumi I. Nonaka, Yoshitaka Hishikawa, Ronald T. Ogata, Masaru Nonaka, Hayato Kawakami, Takehiko Koji, Nobuo Moriyama, Akihiko Kudo   +7 more
openaire   +4 more sources

Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli

Kidney International, 1986
Monoclonal antibodies reactive against the complement C4A and C4B isotypic components were used in an immunoperoxidase technique for the histological study of normal human renal tissue. Prominent staining with both antibodies was seen in the mesangial areas of all normal kidney sections investigated.
Helmut E. Feucht, Angelika Brase, Michael J. Gokel, Geoffrey J. O'Neill, J. Zwirner, Eckhard Held, Gert Riethmüller, Christina M. Jung   +7 more
openaire   +4 more sources

Proteomic and In Silico Analyses Highlight Complement System's Role in Bladder Cancer Immune Regulation. [PDF]

Medicina (Kaunas)
Background and Objectives: Bladder cancer (BLCA), intimately associated with the immune system, represents a substantial global health burden due to its high recurrence rates and limited therapeutic effectiveness.
Korak T, Baloğlu İH, Kasap M, Arisan ED, Akpinar G, Arisan S.   +5 more
europepmc   +2 more sources

Intraocular complement activation is independent of systemic complement activation and is related to macular vascular remodelling in retinal vein occlusion. [PDF]

BMC Ophthalmol
Background Retinal vein occlusion (RVO) is a major cause of vision loss. The pathogenesis remains poorly defined although inflammation is known to play a critical role.
Liu H, Zhou Y, Qi J, Liang S, Guo T, Chen J, Tan H, Wang J, Xu H, Chen Z.   +9 more
europepmc   +2 more sources

The region Ser³³³‐Arg³⁵⁶ of the α‐chain of human C4b‐binding protein is involved in the binding of complement C4b

FEBS Letters, 1993
Human C4b‐binding protein (C4BP) functions as a cofactor to factor I in the degradation of C4b and accelerates the decay rate of the C4b2a complex. In this study we describe a monoclonal antibody directed against the α‐chain of C4BP that inhibits the binding of C4b to C4BP.
Sadaaki Iwanaga, Bonno N. Bourna, Deon Kanters, Martin Hessing, Cornelis van 't Veer, Hiroyuki Takeya, Tilman M. Hackeng   +6 more
openaire   +4 more sources

Intraperitoneal MASP-1 Levels are Associated with Peritoneal Solute Transport Rate in Peritoneal Dialysis Patients: A Retrospective Cohort Study. [PDF]

J Inflamm Res
Jianzhong Li,1,* Yan Xiong,2,* Mingyu Chen,1,* Deyu Xu,1 Ling Zhou,1 Lei Shen,1 Guoyuan Lu1 1Department of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, People’s Republic of China; 2Department of ...
Li J, Xiong Y, Chen M, Xu D, Zhou L, Shen L, Lu G.   +6 more
europepmc   +2 more sources

Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b [PDF]

Proceedings of the National Academy of Sciences, 2019
Antigen binding by serum Ig-M (IgM) protects against microbial infections and helps to prevent autoimmunity, but causes life-threatening diseases when mistargeted. How antigen-bound IgM activates complement-immune responses remains unclear. We present cryoelectron tomography structures of IgM, C1, and C4b complexes formed on antigen-bearing lipid ...
Sharp, Thomas H., Boyle, Aimee L., Diebolder, Christoph A., Kros, Alexander, Koster, Abraham J., Gros, Piet   +5 more
openaire   +9 more sources

Plasma Levels of Complement Factor I and C4b Peptides Are Associated with HIV Suppression [PDF]

ACS Infectious Diseases, 2017
Individuals who exhibit long-term HIV suppression and CD4 T-cell preservation without antiretroviral therapy are of great interest for HIV research. There is currently no robust method for rapid identification of these "HIV controller" subjects; however, HLA-B*57 (human leukocyte antigen (major histocompatibility complex), class I, B*57) genotype ...
Ye Hu, Ye Hu, Christopher R. Bone, Zhen Zhao, Boan Li, Jason T. Kimata, Xu G. Yu, Wei Zhang, Christopher J. Lyon, Christopher J. Lyon, Zhengyu Ouyang, Boyue Wu, Tori Clift   +12 more
openaire   +4 more sources

The Hyphal and Yeast Forms ofCandida albicansBind the Complement Regulator C4b-Binding Protein [PDF]

Infection and Immunity, 2004
ABSTRACTCandida albicans, an important pathogenic yeast, activates all three pathways of the complement system. To understand how this yeast evades the effects of the activated system, we have analyzed the binding of the classical pathway inhibitor C4b-binding protein (C4BP) byC. albicans.
Meri, T, Blom, Anna, Hartmann, A, Lenk, D, Meri, S, Zipfel, P. F.   +5 more
openaire   +5 more sources

Microarray analysis of the effects of Acthar Gel versus methylprednisolone in a model of focal segmental glomerulosclerosis in female rats [PDF]

Physiological Reports, Volume 13, Issue 7, April 2025.
Effect of Acthar® Gel versus methylprednisolone on gene expression in a female rat model of focal segmental glomerulosclerosis. Abstract Acthar® Gel (repository corticotropin injection) is an alternative treatment for patients with focal segmental glomerulosclerosis (FSGS) who cannot tolerate or do not adequately respond to glucocorticoids or ...
Kyle Hayes, Dale Wright
wiley   +2 more sources