Results 21 to 30 of about 8,609 (172)
The C4A and C4B Isotypic Forms of Human Complement Fragment C4b Have the Same Intrinsic Affinity for Complement Receptor 1 (CR1/CD35) [PDF]
The Journal of Immunology, 2004 AbstractSeveral previous reports concluded that the C4b fragment of human C4A (C4Ab) binds with higher affinity to CR1 than does C4Bb. Because the isotypic residues, 1101PCPVLD and 1101LSPVIH in C4A and C4B, respectively, are located within the C4d region, one may have expected a direct binding contribution of C4d to the interaction with CR1.
Liliana, Clemenza, David E, Isenman
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Research and Practice in Thrombosis and Haemostasis, 2022 Background The factor XIII (FXIII)‐B subunit has a critical function as a carrier protein to stabilize FXIII‐A in plasma and supply it to its main substrate, fibrinogen.
Bojun Li +4 more
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Frontiers in Immunology, 2022 Multidrug-resistant Acinetobacter baumannii is known to be one of the leading pathogens that cause severe nosocomial infections. To overcome eradication by the innate immune system during infection, A.
Julia I. Ries +6 more
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Molecules, 2022 Exosomes are small extracellular vesicles with a variable protein cargo in consonance with cell origin and pathophysiological conditions. Gestational diabetes mellitus (GDM) is characterized by different levels of chronic low-grade inflammation and ...
Elena G. Bernea +9 more
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Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement. [PDF]
PLoS ONE, 2012 Microbial pathogens acquire the immediate imperative to avoid or counteract the formidable defense of innate immunity as soon as they overcome the initial physical barriers of the host. Many have adopted the strategy of directly disrupting the complement
Henry A Choy
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The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes. [PDF]
PLoS ONE, 2009 Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
Veruska Cavalcanti Barros +7 more
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C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus
Frontiers in Immunology, 2021 C4b Binding Protein (C4BP) is a major fluid phase inhibitor of the classical and lectin pathways of the complement system. Complement inhibition is achieved by binding to and restricting the role of activated complement component C4b. C4BP functions as a
Praveen M. Varghese +11 more
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Degradation of human complement component C4b in the presence of the C4b-binding protein-protein S complex [PDF]
Biochemical Journal, 1983 Vitamin K-dependent protein S and the higher-molecular-weight form of C4b-binding protein (C4bp-high) interact, forming a 1:1 complex with a KD of approx. 1×10(-7) M [Dahlbäck (1983) Biochem. J. 209, 847-856]. In the present study the effect of protein S on the degradation of C4b by Factor I (C3b inactivator) and C4bp was investigated both in fluid ...
B, Dahlbäck, B, Hildebrand
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Hypomorphic C4B∗ 15 variant of the fourth component of complement [PDF]
FEBS Letters, 1990 We report a rare ‘hypomorphic’ C4 allotype detected during routine screening in controls for the Rogers:1 epitope. C4B∗15 was distinguished by having only faint staining when using polyclonal anti‐C4 antibody on agarose inimunoelectrophoresis (e.g.
Christenson, Marie J. +4 more
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The Molecular Mechanisms of Complement Receptor 1—It Is Complicated
Biomolecules, 2023 Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus on the
Matthew P. Hardy +3 more
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