C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus
Frontiers in Immunology, 2021 C4b Binding Protein (C4BP) is a major fluid phase inhibitor of the classical and lectin pathways of the complement system. Complement inhibition is achieved by binding to and restricting the role of activated complement component C4b. C4BP functions as a
Praveen M. Varghese +11 more
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The Molecular Mechanisms of Complement Receptor 1—It Is Complicated
Biomolecules, 2023 Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus on the
Matthew P. Hardy +3 more
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Degradation of human complement component C4b in the presence of the C4b-binding protein-protein S complex [PDF]
Biochemical Journal, 1983 Vitamin K-dependent protein S and the higher-molecular-weight form of C4b-binding protein (C4bp-high) interact, forming a 1:1 complex with a KD of approx. 1×10(-7) M [Dahlbäck (1983) Biochem. J. 209, 847-856]. In the present study the effect of protein S on the degradation of C4b by Factor I (C3b inactivator) and C4bp was investigated both in fluid ...
B, Dahlbäck, B, Hildebrand
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Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
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Hypomorphic C4B∗ 15 variant of the fourth component of complement [PDF]
FEBS Letters, 1990 We report a rare ‘hypomorphic’ C4 allotype detected during routine screening in controls for the Rogers:1 epitope. C4B∗15 was distinguished by having only faint staining when using polyclonal anti‐C4 antibody on agarose inimunoelectrophoresis (e.g.
Christenson, Marie J. +4 more
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Inflammatory and Complement Biomarkers of Cognitive Decline in Astrocyte‐Derived Extracellular Vesicles from the Vietnam Era Twin Study of Aging [PDF]
Alzheimers DementAbstract Background Traumatic brain injury (TBI) is a significant risk factor for Alzheimer's disease (AD) and cognitive decline, yet biomarkers identifying persistent neuroinflammation following TBI remain underexplored. Astrocyte‐derived small extracellular vesicles (AEVs) from plasma encapsulate inflammatory cytokines and complement proteins ...
Cullum‐Doyle M +6 more
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Complement C4A Regulates Autoreactive B Cells in Murine Lupus
Cell Reports, 2020 Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact.
Léa Simoni +6 more
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Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]
, 2014 Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L. +8 more
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Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode [PDF]
, 2016 Item does not contain ...
Atkinson, John P +14 more
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Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae [PDF]
Infection and Immunity, 2007 ABSTRACTComplement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide onNeisseria meningitidisas an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization
Lisa A. Lewis +7 more
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