Results 41 to 50 of about 697,969 (251)

An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase

Journal of Immunology, 2020
Key Points hC4Nb8 is a potent cross-reactive inhibitor of CP and LP proconvertase formation. hC4Nb8 binds to a neoepitope exposed upon C4 activation and C4b generation. hC4Nb8 inhibits the CP of complement in vivo.
A. Zarantonello, J. Presumey, Léa Simoni, Esra Yalcin, Rachel Fox, A. Hansen, H. Olesen, S. Thiel, Matthew B. Johnson, B. Stevens, N. S. Laursen, M. Carroll, G. Andersen   +12 more
semanticscholar   +1 more source

Complementation of Subquandles [PDF]

Involve 18 (2025) 417-435, 2023
Saki and Kiani proved that the subrack lattice of a rack $R$ is necessarily complemented if $R$ is finite but not necessarily complemented if $R$ is infinite. In this paper, we investigate further avenues related to the complementation of subquandles.
arxiv   +1 more source

Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement. [PDF]

PLoS ONE, 2012
Microbial pathogens acquire the immediate imperative to avoid or counteract the formidable defense of innate immunity as soon as they overcome the initial physical barriers of the host. Many have adopted the strategy of directly disrupting the complement
Henry A Choy
doaj   +1 more source

The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes. [PDF]

PLoS ONE, 2009
Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
Veruska Cavalcanti Barros, Jéssica Góes Assumpção, André Miranda Cadete, Vânia Cristina Santos, Reginaldo Roris Cavalcante, Ricardo Nascimento Araújo, Marcos Horácio Pereira, Nelder Figueiredo Gontijo   +7 more
doaj   +1 more source

C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus

Frontiers in Immunology, 2021
C4b Binding Protein (C4BP) is a major fluid phase inhibitor of the classical and lectin pathways of the complement system. Complement inhibition is achieved by binding to and restricting the role of activated complement component C4b. C4BP functions as a
Praveen M. Varghese, Praveen M. Varghese, Valarmathy Murugaiah, Nazar Beirag, Nigel Temperton, Haseeb A. Khan, Salman H. Alrokayan, Mohammed N. Al-Ahdal, Beatrice Nal, Futwan A. Al-Mohanna, Robert B. Sim, Uday Kishore   +11 more
doaj   +1 more source

The Molecular Mechanisms of Complement Receptor 1—It Is Complicated

Biomolecules, 2023
Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus on the
Matthew P. Hardy, Mariam Mansour, Tony Rowe, Sandra Wymann   +3 more
doaj   +1 more source

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]

PLoS Neglected Tropical Diseases, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Markus M Simon, Reinhard Wallich   +5 more
doaj   +1 more source

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

npj Genomic Medicine, 2022
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk.
Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeón-Aznar, José Luis Callejas, Shervin Assassi, International SSc Group, Susanna M. Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), PRECISESADS Clinical Consortium, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K. de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L. Herrick, Chikashi Terao, Yannick Allanore, Carmen Fonseca, Marta Eugenia Alarcón-Riquelme, Timothy R. D. J. Radstake, Lorenzo Beretta, Christopher P. Denton, Maureen D. Mayes, Javier Martin   +24 more
doaj   +1 more source

SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation

Frontiers in Immunology, 2022
Antibodies specific for the spike glycoprotein (S) and nucleocapsid (N) SARS-CoV-2 proteins are typically present during severe COVID-19, and induced to S after vaccination.
Rachel E. Lamerton, Rachel E. Lamerton, Edith Marcial-Juarez, Sian E. Faustini, Marisol Perez-Toledo, Margaret Goodall, Siân E. Jossi, Maddy L. Newby, Iain Chapple, Thomas Dietrich, Tonny Veenith, Adrian M. Shields, Lorraine Harper, Ian R. Henderson, Julie Rayes, David C. Wraith, Steve P. Watson, Max Crispin, Mark T. Drayson, Alex G. Richter, Adam F. Cunningham   +20 more
doaj   +1 more source

Domain structure of human complement C4b extends with increasing NaCl concentration: implications for its regulatory mechanism.

Biochemical Journal, 2016
During the activation of complement C4 to C4b, the exposure of its thioester domain (TED) is crucial for the attachment of C4b to activator surfaces.
Ka Wai Fung, D. Wright, J. Gor, M. Swann, S. Perkins   +4 more
semanticscholar   +1 more source