Results 51 to 60 of about 712,823 (260)

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

npj Genomic Medicine, 2022
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk.
Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeón-Aznar, José Luis Callejas, Shervin Assassi, International SSc Group, Susanna M. Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), PRECISESADS Clinical Consortium, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K. de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L. Herrick, Chikashi Terao, Yannick Allanore, Carmen Fonseca, Marta Eugenia Alarcón-Riquelme, Timothy R. D. J. Radstake, Lorenzo Beretta, Christopher P. Denton, Maureen D. Mayes, Javier Martin   +24 more
doaj   +1 more source

Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. [PDF]

, 2019
IntroductionLevels of complement proteins (CPs) in plasma astrocyte-derived exosomes (ADEs) that are abnormal in Alzheimer's disease (AD) have not been assessed in mild cognitive impairment (MCI).MethodsParticipants (n = 20 per group) had either MCI ...
Elahi, Fanny M, Goetzl, Edward J, Rissman, Robert A, Schwartz, Janice B, Winston, Charisse N   +4 more
core   +2 more sources

Spatially resolved transcriptomics/proteomics identifies increased inflammatory response in Alzheimer’s disease patients with Cerebral Amyloid Angiopathy [PDF]

Alzheimers Dement
Abstract Background Cerebral amyloid angiopathy (CAA) is a major co‐pathology exhibited by over 80% of Alzheimer's disease (AD) patients. This neuropathological hallmark is defined by an accumulation of amyloid deposits in cerebral cortical and leptomeningeal vessels.
Weng J, Noristani H, Schuldt C, Lacor P.
europepmc   +4 more sources

Identification of the Kna/Knb polymorphism and a method for Knops genotyping [PDF]

, 2004
BACKGROUND: DNA mutations resulting in the McCoy and Swain-Langley polymorphisms have been identified on complement receptor 1 (CR1)—a ligand for rosetting of Plasmodium falciparum-infected RBCs.
Daniels, Helgeson, Krych-Goldberg, Mallan, Molthan, Molthan, Moulds, Moulds, Moulds, Moulds, Moulds, Moulds, Moulds, Moulds, Rao, Rowe, Tamasauskas, Zimmerman   +17 more
core   +1 more source

Investigation of complement component C4 copy number variation in human longevity. [PDF]

PLoS ONE, 2014
Genetic factors have been estimated to account for about 25% of the variation in an adult's life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences in the overall C4 copy number or
Friederike Flachsbart, Amke Caliebe, Femke-Anouska Heinsen, Tom Hemming-Karlsen, Stefan Schreiber, Andre Franke, Almut Nebel   +6 more
doaj   +1 more source

SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation

Frontiers in Immunology, 2022
Antibodies specific for the spike glycoprotein (S) and nucleocapsid (N) SARS-CoV-2 proteins are typically present during severe COVID-19, and induced to S after vaccination.
Rachel E. Lamerton, Rachel E. Lamerton, Edith Marcial-Juarez, Sian E. Faustini, Marisol Perez-Toledo, Margaret Goodall, Siân E. Jossi, Maddy L. Newby, Iain Chapple, Thomas Dietrich, Tonny Veenith, Adrian M. Shields, Lorraine Harper, Ian R. Henderson, Julie Rayes, David C. Wraith, Steve P. Watson, Max Crispin, Mark T. Drayson, Alex G. Richter, Adam F. Cunningham   +20 more
doaj   +1 more source

CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]

, 1991
Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Dierich, Manfred P., Estaller, C., Koistinen, V., Schwaeble, W., Weiss, Elisabeth H.   +4 more
core   +2 more sources

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]

PLoS Neglected Tropical Diseases, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Markus M Simon, Reinhard Wallich   +5 more
doaj   +1 more source

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]

, 2015
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A, Anstaett, O L, Brownlie, J, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +6 more
core   +2 more sources

Structural and functional studies of complement inhibitor C4b-binding protein [PDF]

Biochemical Society Transactions, 2002
C4b-binding protein (C4BP) is a potent inhibitor of the classical pathway of the complement system. This large plasma glycoprotein consists of seven identical α-chains and a unique β-chain held together by disulphide bridges. Both types of subunits are composed almost exclusively of complement control protein domains (CCPs).
openaire   +3 more sources