Results 61 to 70 of about 697,969 (251)

Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction.

International Immunology, 2008
BACKGROUND AND OBJECTIVES Some recent data indicate that risk of death after acute coronary syndrome is under genetic control. Previously, we found that the C4B*Q0 genotype (low copy number of the C4B gene that encodes the fourth component of complement)
B. Blaskó, R. Kolka, Perla Thorbjornsdottir, S. Sigurdarson, G. Sigurdsson, Z. Rónai, M. Sasvári-Székely, S. Bödvarsson, G. Thorgeirsson, Z. Prohászka, M. Kovács, G. Füst, G. Arason   +12 more
semanticscholar   +1 more source

Importance of the α₃‐fragment of complement C4 for the binding with C4b‐binding protein [PDF]

FEBS Letters, 1990
The human regulatory complement component C4b‐binding protein (C4BP) is a multimene plasma protein, which regulates the classical pathway of the complement system. C4BP functions as a cofactor to factor 1 in the degradation of C4b and accelerates the decay rate of the C4b2a complex.
Martin Hessing, Sadaaki Iwanaga, Bonno N. Bouma, Cornells van't Veer, Tilman M. Hackeng   +4 more
openaire   +3 more sources

Yersinia enterocolitica serum resistance proteins YadA and ail bind the complement regulator C4b-binding protein. [PDF]

PLoS Pathogens, 2008
Many pathogens are equipped with factors providing resistance against the bactericidal action of complement. Yersinia enterocolitica, a Gram-negative enteric pathogen with invasive properties, efficiently resists the deleterious action of human ...
Vesa Kirjavainen, Hanna Jarva, Marta Biedzka-Sarek, Anna M Blom, Mikael Skurnik, Seppo Meri   +5 more
doaj   +1 more source

Interaction between Protein S and Complement C4b-binding Protein (C4BP)

Journal of Biological Chemistry, 1999
Human C4b-binding protein (C4BP) is a regulator of the complement system and plays an important role in the regulation of the anticoagulant protein C pathway.
R. H. van de Poel, J. Meijers, B. Bouma
semanticscholar   +1 more source

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b. [PDF]

Proceedings of the National Academy of Sciences, 1983
C4b-binding protein (C4bp) participates in the regulation of the C3 convertase of the classical pathway of complement. By binding to C4b, which is one of the structural subunits of this enzyme, C4bp accelerates the decay-dissociation of the enzyme and renders C4b susceptible to degradation by factor I (C3b inactivator).
C A Smith, H J Müller-Eberhard, Björn Dahlbäck   +2 more
openaire   +3 more sources

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.

PLoS Pathogens, 2022
The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo, Heather L Jewhurst, József Dobó, Péter Gál, John P Dalton, Krystyna Cwiklinski   +5 more
doaj   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source

Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL)

Frontiers in Immunology, 2019
APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10–15% have a manifestation of secondary APS.
Stephanie L. Savelli, Stephanie L. Savelli, Stephanie L. Savelli, Robert A. S. Roubey, Kathryn J. Kitzmiller, Kathryn J. Kitzmiller, Danlei Zhou, Danlei Zhou, Danlei Zhou, Haikady N. Nagaraja, Evan Mulvihill, Evan Mulvihill, Fatima Barbar-Smiley, Fatima Barbar-Smiley, Stacy P. Ardoin, Stacy P. Ardoin, Yee Ling Wu, Yee Ling Wu, Yee Ling Wu, Chack-Yung Yu, Chack-Yung Yu, Chack-Yung Yu   +21 more
doaj   +1 more source

Identification of serum C4BPA as a potential diagnostic marker of right ventricular remodelling via proteomic analysis

ESC Heart Failure, EarlyView.
Abstract Aims Right ventricular (RV) remodelling, a progressive condition characterized by maladaptive cardiac structural and functional changes, primarily results from prolonged pressure overload in patients with pulmonary hypertension (PH). Accurate, universal and easy‐to‐use biomarkers for assessing the severity of RV remodelling are lacking.
Xuenan Wang, Cheng Yu, Meiling Li, Huiling Cai, Yongjian Yang, Cong Lan   +5 more
wiley   +1 more source

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

eLife, 2020
The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3 ...
Percy Griffin, Patrick W Sheehan, Julie M Dimitry, Chun Guo, Michael F Kanan, Jiyeon Lee, Jinsong Zhang, Erik S Musiek   +7 more
doaj   +1 more source