Results 61 to 70 of about 8,609 (172)

Expression of Human Thrombomodulin Prevents Early Thrombocytopenia and Thrombotic Microangiopathy in Pig‐to‐Nonhuman Primate Orthotopic Liver Xenotransplantation

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
Abstract Background Severe thrombocytopenia and coagulation dysregulation remain major barriers to survival in pig‐to‐primate liver xenotransplantation models. Methods Porcine livers with five genetic modifications (GTKO, CMAHKO, β4GalNT2KO, hCD55, and hTBM) were orthotopically transplanted into four Tibetan macaques under two conventional ...
Zhongqiang Zhang, Ting Li, Qiang Li, Bin Xie, Xinger Zhao, Jianbin Wang, Yaxun Huang, Jing Luo, Shali Wen, Yinchun Zhou, Yong Deng, Yanfang Lu, Yanyan Jiang, Jiequn Li, David K. C. Cooper, Dengke Pan, Zhongzhou Si, Haizhi Qi   +17 more
wiley   +1 more source

Increased frequency of the null allele at the complement C4b locus in autism [PDF]

Clinical and Experimental Immunology, 1991
SUMMARY Associations between C4 deficiency and autoimmune disorders have been found over the past several years. Since autism has several autoimmune features, the frequencies of null (no protein produced) alleles at the C4A and C4B loci were studied in 19 subjects with autism and their family members.
R P, Warren, V K, Singh, P, Cole, J D, Odell, C B, Pingree, W L, Warren, E, White   +6 more
openaire   +2 more sources

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, Volume 13, Issue 8, 9 February 2026.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +1 more source

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b. [PDF]

Proceedings of the National Academy of Sciences, 1983
C4b-binding protein (C4bp) participates in the regulation of the C3 convertase of the classical pathway of complement. By binding to C4b, which is one of the structural subunits of this enzyme, C4bp accelerates the decay-dissociation of the enzyme and renders C4b susceptible to degradation by factor I (C3b inactivator).
B, Dahlbäck, C A, Smith, H J, Müller-Eberhard   +2 more
openaire   +2 more sources

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

How Escherichia coli Circumvent Complement-Mediated Killing

Frontiers in Immunology, 2017
Complement is a crucial arm of the innate immune response against invading bacterial pathogens, and one of its main functions is to recognize and destroy target cells.
Angela S. Barbosa, Afonso G. Abreu, Afonso G. Abreu   +2 more
doaj   +1 more source

Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma

World Journal of Surgical Oncology, 2022
Purpose Liver cancer is one of the most common tumors with the seventh-highest incidence and the third-highest mortality. Many studies have shown that small extracellular vesicles (sEVs) play an important role in liver cancer.
Wei Dong, Zeyu Xia, Zehua Chai, Zhidong Qiu, Xuehong Wang, Zebin Yang, Junnan Wang, Tingrui Zhang, Qinqin Zhang, Junfei Jin   +9 more
doaj   +1 more source

The insider's perspective: The intracellular complosome and immune cell dynamics in cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Intracellular complement (complosome) shapes the tumour immune microenvironment. Complosome's role in cancer is underrecognised yet central to tumour immunity. C3/C5‐driven complosome signals rewire T‐cell activation, fate and metabolism. Complosome activity can promote pro‐tumour immune cell function.
Alexandra Bennion, Joanne Lysaght, Niamh Lynam‐Lennon   +2 more
wiley   +1 more source

Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes.

Journal of Biological Chemistry, 1990
C4b-binding protein (C4BP) is a large complex assembly of eight subunits that functions as an inhibitor of the complement cascade. A portion of the C4BP in serum exists as a complex with protein S. This study demonstrated that another protein, serum amyloid P component (SAP), also formed a calcium-dependent complex with C4BP.
R A, Schwalbe, B, Dahlbäck, G L, Nelsestuen   +2 more
openaire   +2 more sources