Results 71 to 80 of about 8,609 (172)

The region Ser³³³‐Arg³⁵⁶ of the α‐chain of human C4b‐binding protein is involved in the binding of complement C4b [PDF]

FEBS Letters, 1993
Human C4b‐binding protein (C4BP) functions as a cofactor to factor I in the degradation of C4b and accelerates the decay rate of the C4b2a complex. In this study we describe a monoclonal antibody directed against the α‐chain of C4BP that inhibits the binding of C4b to C4BP.
Hessing, M., Kanters, D., Takeya, H., Veer, C. van 't, Hackeng, T.M., Iwanaga, S., Bouma, B.N.   +6 more
openaire   +2 more sources

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

Emerging methods for subtype differentiation in primary aldosteronism

Journal of Internal Medicine, Volume 299, Issue 2, Page 178-195, February 2026.
Abstract Primary aldosteronism (PA) is a common cause of hypertension. Compared to patients with essential hypertension, untreated PA is associated with a two‐ to fourfold greater risk of cardiovascular disease, renal failure, and death. PA is caused by increased secretion of aldosterone from one adrenal gland in 30% of the patients and both adrenal ...
Oskar Ragnarsson, C. Christofer Juhlin, Tobias Åkerström, Per Dahlqvist, Henrik Falhammar, Per Hellman   +5 more
wiley   +1 more source

Intraocular complement activation is independent of systemic complement activation and is related to macular vascular remodelling in retinal vein occlusion

BMC Ophthalmology
Background Retinal vein occlusion (RVO) is a major cause of vision loss. The pathogenesis remains poorly defined although inflammation is known to play a critical role.
Hengwei Liu, Yufan Zhou, Jinyan Qi, Shengnan Liang, Tingting Guo, Juan Chen, Huanhuan Tan, Jie Wang, Heping Xu, Zhongping Chen   +9 more
doaj   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, Volume 604, Issue 4, Page 1558-1574, 15 February 2026.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity.

The Journal of biological chemistry, 2003
We identified Neisseria meningitidis lipooligosaccharide (LOS) as an acceptor for complement component C4b (C4b). Phosphoethanolamine (PEA) residues on the second heptose (HepII) residue in the LOS core structure formed amide linkages with C4b. PEA at the 6-position of HepII (6-PEA) was more efficient than 3-PEA in binding C4b.
Seppo Meri, J. Claire Wright, Peter A. Rice, Sunita Gulati, Sanjay Ram, Ulrich Vogel, Daniel C. Stein, E. Richard Moxon, Ryan Boden, Andrew D. Cox, Silke Getzlaff, James C. Richards, Jianjun Li, Joyce S. Plested   +13 more
openaire   +3 more sources

Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain‐first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain unclear. METHODS We conducted a proteomic and microbial analysis of transverse colon samples from clinically and pathologically confirmed AD and ...
Qiwen Cheng, Jennifer Nolz, Timothy Karr, Nicole Dorn, Benjamin Readhead, Rosa Krajmalnik‐Brown, Diego Mastroeni   +6 more
wiley   +1 more source

Non‐Targeted Analysis of Extracellular Vesicle‐Enriched Plasma Proteome Between Early and Late Rugby Playing Career

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Purpose Rugby players experience high‐impact collisions, potentially increasing their risk of neurodegenerative conditions. This study investigates whether the plasma proteome of extracellular vesicles (EV) provides biomarkers to indicate differential risk associated with a rugby career.
Abhishek Jagan, Yusuke Nishimura, Tim Donovan, Jatin G. Burniston   +3 more
wiley   +1 more source

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study.

PLoS Neglected Tropical Diseases
BackgroundNumerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement
Anuradha Rajamanickam, Bindu Dasan, Saravanan Munisankar, Sujatha Nott, Pradeep A Menon, Fayaz Ahamed Shaik, Ponnuraja Chinnaiyan, Thomas B Nutman, Subash Babu   +8 more
doaj   +1 more source

Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria.

PLoS ONE, 2012
Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected ...
Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow   +9 more
doaj   +1 more source