Results 81 to 90 of about 712,823 (260)

Spirochetal Lipoproteins and Immune Evasion. [PDF]

, 2017
Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani, Christodoulides, Alexei, Kelesidis, Theodoros   +2 more
core   +1 more source

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.

PLoS Pathogens, 2022
The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo, Heather L Jewhurst, József Dobó, Péter Gál, John P Dalton, Krystyna Cwiklinski   +5 more
doaj   +1 more source

Structure of Complement Component C2a: Implications for Convertase Formation and Substrate Binding [PDF]

, 1906
SummaryC2a provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation. We determined two crystal structures of full-length C2a, with and without a pseudo ligand bound.
Fin J. Milder, Hans C.A. Raaijmakers, Mitja D.A.A. Vandeputte, Arie Schouten, Eric G. Huizinga, Roland A. Romijn, Wieger Hemrika, Anja Roos, Mohamed R. Daha, Piet Gros, Barash, Bentley, Bhattacharya, Bode, Brunger, Crump, Durocher, Emsley, Emsley, Fredslund, Graham, Hinshelwood, Horiuchi, Janssen, Jin, Jing, Jones, Kallen, Kam, Kerr, Kerr, Khan, Leslie, Murshudov, Palmiter, Pangburn, Perona, Ponnuraj, Rawal, Roos, Shimaoka, Song, Storoni, Tomana, Walport, Walport, Wattanasin, Winn   +47 more
core   +1 more source

Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma

Allergy, EarlyView.
Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong, Shaohua Lu, Zhenan Deng, Xuliang Cai, Huahao Shen, Guochao Shi, Changxing Ou, Zuofu Peng, Wei Jiang, Xiuhua Fu, Changzheng Wang, Meiling Jin, Zhongmin Qiu, Xiaoyang Wei, Wei Gu, Kewu Huang, Qiang Li, Xiangyan Zhang, Nanshan Zhong, Kian Fan Chung, Qingling Zhang, on behalf of C‐BIOPRED Consortium, Jiangtao Lin, Yongming Zhang, Nan Su, Xiaoyan Zhang, Qing Zhao, Ying Nong, Ping Chen, Tianyi Zhu, Binbin Ji, Yan Wang, Haitao Zhao, Jinbao Wang, Zhiyuan Zhang, Xiaona Yang, Chunhua Wei, Jing Han, Nong Yu, Qiang Li, Zhifu Yang, Yanhong Liu, Guohua Li, Huadong Guan, Shuping Zhang, Xiuhua Fu, Lihong Wang, Lingxin Meng, Zhenting Sun, Guangqin Cao, Lei Zhao, Kewu Huang, Hong Zhang, Wen Wang, Li An, Yangyu Chen, Yanli Gao, Xiaoxia Liu, Huifen Zhai, Fang Lin, Zhaohui Zhong, Zhongguang Wen, Yan Xiao, Jian Kang, Linfei Kong, Xinming Su, Xue Yan, Dijia Zhou, Huaping Tang, Wei Han, Yi Shu, Tintian Li, Lixin Xie, Hong Hu, Bo Liu, Yuzhu Li, Longmei Fan, Yue Zhang, Shifeng Zhao, Xiaofang Liu, Yuhong Wang, Xichun Zhang, Xinmao Wang, Pen Bai, Guangfa Wang, Yan Hu, Zhanwei Hu, Ju Cao, Bei He, Rui Wu, Xiaoyan Gai, Hong Zhu, Zhihai Han, Jiyi Meng, Wei Chen, Li Ma, Zhenqian Liu, Chunyang Zhang, Yan Zhang, Huahao Shen, Fugui Yan, Bin Shen, Xinghong Wang, Hao Zhang, Yinghua Yin, Jinkai Liu, Yanxiong Mao, Mao Huang, Xin Yao, Mao Huang, Ji Zhou, Zhenzhen Wu, Ping Yan, Yujie Zhang, Xinling Yang, Ningfei Ji, Fan Fei, Wanzhen Fu, Yi Yang, Yuting Shi, Wangjian Cha, Guochao Shi, Min Zhou, Wei Tang, Wei Chen, Jun Zhou, Wenjie Yang, Lei Zhu, Meiling Jin, Liping Xue, Li Li, Chun Li, Yin Gong, Qiang Li, Guogang Xie, Luhong Bao, Wuping Bao, Nianyun Li, Fengming Ding, Min Zhang, Zhongmin Qiu, Li Yu, Jungang Xie, Lingling Yi, Xianghuai Xu, Qiang Chen, Junjun Tang, Jinfu Xu, Xiaobing Ji, Jingyun Shi, Bo Su, Xiaojun Yang, Jiuwen Bai, Shuo Liang, Kebing Cheng, Wei Gu, Jiyong Ma, Yun Liu, Jun Ren, Shan Mao, Qingling Zhang, Baoqing Sun, Jiaxing Xie, Rihuang Qiu, Zhiqiang Wang, Peiyan Zhen, Wenting Luo, Changgao Zhong, Wei Luo, Yanqing Xie, Xinxin Yu, Wenting Yu, Wei He, Changzheng Wang, Qianli Ma, Min Wan, Mingzhou Zhang, Haining Li, Shaoxi Cai, Haijin Zhao, Yanmei Ye, Fang Zhou, Laiyu Liu, Guohua Huang, Jianpeng Liang, Jianping Zhao, Jungang Xie, Qiongjie Hu, Kaiyan Li, Wang Ni, Guohua Zheng, Weining Xiong, Lingling Yi, Xihu Du, Yunhui Zhang, Zhi Li, Xiaoqiong Tan, Feng Liao, Shenglan Wang, Yijiang Huang, Xinjun Cai, Kai Liu, Shaojing Sheng, Yihui Fu, Shenghua Sun, Qiang Zhang, Jinweng Cai, Ye Ling, Pin Chen, Hong Luo, Lv Liu, Zhijun Liu, Yuling Tang, Yusheng Yan, Guiyan Mo, Long Wen, Yinqun Zhu, Du Fan   +217 more
wiley   +1 more source

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

eLife, 2020
The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3 ...
Percy Griffin, Patrick W Sheehan, Julie M Dimitry, Chun Guo, Michael F Kanan, Jiyeon Lee, Jinsong Zhang, Erik S Musiek   +7 more
doaj   +1 more source

Carriership of a defective tenascin-X gene in steroid 21-hydroxylase deficiency patients: TNXB -TNXA hybrids in apparent large-scale gene conversions [PDF]

, 2002
Steroid 21-hydroxylase deficiency is caused by a defect in the CYP21A2 gene. CYP21A2, the adjacent complement C4 gene and parts of the flanking genes RP1 and TNXB constitute a tandemly duplicated arrangement in the central (class III ...
Degenhart, H.J. (Herman), Hoogenboezem, T. (Theo), Koppens, P.F.J.   +2 more
core   +2 more sources

A covalent dimer of complement C4b serves as a subunit of a novel C5 convertase that involves no C3 derivatives.

Journal of Immunology, 1991
A C intermediate, LAC14, was prepared from TNP-aminocaproyl liposomes sensitized with anti-TNP antibody (Ab) and purified human C1 and C4. LAC14, containing radiolabeled C4, was analyzed by SDS-PAGE followed by autoradiography, and yielded a 210-kDa band
T. Masaki, M. Matsumoto, R. Yasuda, R. Levine, H. Kitamura, T. Seya   +5 more
semanticscholar   +1 more source

Neoadjuvant Therapy‐Induced Remodeling in Pancreatic Ductal Adenocarcinoma: Multimodal Spatial Analysis and Prognosis

Cancer Science, EarlyView.
Using integrated spatial pathomics and transcriptomics, we show that neoadjuvant therapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) induces substantial tumor microenvironment remodeling that is not captured by tumor regression grading (TRG) alone.
Xiaofei Zhang, Ruoxin Lan, Danting Li, Yongjun Liu, Sonu Kalyan, Momin Iqbal, Nancy Liu, Jerry Zhang, Iman Hanna, Mala Gupta, Chaohui L. Zhao, Weiguo Liu, Jonathan Melamed, Michael Shusterman, Jessica Widmer, John Allendorf, Yao‐Zhong Liu   +16 more
wiley   +1 more source

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex [PDF]

, 2016
Citation: Garcia, B. L., Zhi, H., Wager, B., Hook, M., & Skare, J. T. (2016). Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. Plos Pathogens, 12(1), 28.
A Alitalo, A Hubner, A Roos, A Sadziene, A Sadziene, AE Davis 3rd, AG Barbour, AP van Dam, B Major, Beau Wager, BK Boardman, Brandon L. Garcia, BV Geisbrecht, C Gaboriaud, CA Brissette, CJ Hastey, CS Brooks, D Ricklin, D Ricklin, D. Scott Samuels, DS Samuels, E Fikrig, EA Rogers, EA Rogers, EH Weening, ER Lewis, G Harris, G Stanek, Girija U Venkatraman, H Zhi, Hui Zhi, I Bally, J Hellwage, J Pietikainen, J Schwab, J Seshu, JA Caine, JA Hyde, JD Lambris, JD Radolf, JH Kim, Jon T. Skare, JR Fischer, JV McDowell, JV McDowell, K Kurtenbach, KM Hovis, LK Bockenstedt, LY Lee, M Hammel, M He, M Jozsi, M Labandeira-Rey, M Pausa, Magnus Höök, MB Lawrenz, MC Carroll, MC Carroll, ME Woodman, MJ Caimano, MN Burtnick, MR Kenedy, MR Kenedy, MU Norman, NA Meenan, NM Thielens, P Kraiczy, P Kraiczy, PF Zipfel, R Wallis, RA Elsner, RA Gaultney, RJ Bingham, RJ Ziccardi, RJ Ziccardi, S Grosskinsky, S Prabhakaran, S Raibaud, S Thiel, SK Kochi, SW de Taeye, T Bykowski, T Hallstrom, T Hallstrom, T Meri, TF Busby, TJ Moriarty, U Schwarz-Linek, UK Laemmli, V Cook, WK Ip, WS Probert, WS Probert, WS Probert, X Li, X Yang, XF Yang, Y Wu, YP Ko, YP Ko, YP Lin, ZR Marjenberg   +101 more
core   +4 more sources

Enolase of Streptococcus pneumoniae Binds Human Complement Inhibitor C4b-Binding Protein and Contributes to Complement Evasion [PDF]

The Journal of Immunology, 2012
Abstract Streptococcus pneumoniae (pneumococcus) is a pathogen that causes severe local and life-threatening invasive diseases, which are associated with high mortality rates. Pneumococci have evolved several strategies to evade the host immune system, including complement to disseminate and to survive in various host niches.
Vaibhav, Agarwal, Sven, Hammerschmidt, Sven, Malm, Simone, Bergmann, Kristian, Riesbeck, Anna M, Blom   +5 more
openaire   +2 more sources