Results 81 to 90 of about 697,969 (251)

Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of Borrelia burgdorferi Elp Proteins

Molecular Microbiology, EarlyView.
A novel approach using the Pseudomonas syringae ice nucleation protein (INP) system to present Borrelia burgdorferi lipoproteins on the surface of Escherichia coli reveals conservation of complement inhibitory functions among uncharacterized OspE/F‐like leader peptide (Elp) proteins.
Nathan Hill, Lara M. Matulina, Cameron MacIntyre, M. Amine Hassani, Sheila Thomas, Matteo Luban, Isabelle Ward, Amina Abdalla, John M. Leong, Brandon L. Garcia, Jacob E. Lemieux   +10 more
wiley   +1 more source

Intracellular degradation of the complement C3b/C4b receptor in the absence of ligand.

Journal of Biological Chemistry, 1988
Human neutrophils (PMN) respond to various soluble stimuli by translocating intracellular complement C3b/C4b receptors (CR1) to the cell surface. Ligand-independent internalization of surface CR1 has been demonstrated previously, but the fate of total cellular CR1 during PMN stimulation has not been determined.
Jerrold R. Turner, Melvin Berger, Alan M. Tartakoff   +2 more
openaire   +3 more sources

Vesiculation as potential novel pathogenic mechanism in autoimmune hemolytic anemia

Transfusion, EarlyView.
Abstract Background Autoimmune hemolytic anemia (AIHA) is typically mediated by immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies, and more rarely by immunoglobulin A (IgA). The mechanism of red blood cell (RBC) destruction in IgA‐mediated AIHA is not well understood.
Esther C. W. de Boer, Femke V. M. Mulder, Silvia Neri, Marije Wiskerke ‐ van Stuijvenberg, Janine J. G. Arts, Simon Tol, Boukje Beuger, Matthieu C. J. Bosman, Noortje Thielen, René van der Griend, Claudia C. Folman, Masja de Haas, Robin van Bruggen, Richard B. Pouw, Josephine M. I. Vos   +14 more
wiley   +1 more source

Complement C4A Regulates Autoreactive B Cells in Murine Lupus

Cell Reports, 2020
Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact.
Léa Simoni, Jessy Presumey, Cees E. van der Poel, Carlos Castrillon, Sarah E. Chang, Paul J. Utz, Michael C. Carroll   +6 more
doaj  

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +1 more source

Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma

World Journal of Surgical Oncology, 2022
Purpose Liver cancer is one of the most common tumors with the seventh-highest incidence and the third-highest mortality. Many studies have shown that small extracellular vesicles (sEVs) play an important role in liver cancer.
Wei Dong, Zeyu Xia, Zehua Chai, Zhidong Qiu, Xuehong Wang, Zebin Yang, Junnan Wang, Tingrui Zhang, Qinqin Zhang, Junfei Jin   +9 more
doaj   +1 more source

Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus

Viruses, 2023
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral ...
Nicole Wagner, Dmitry M. Shayakhmetov, Phoebe L. Stewart   +2 more
doaj   +1 more source

A covalent dimer of complement C4b serves as a subunit of a novel C5 convertase that involves no C3 derivatives.

Journal of Immunology, 1991
A C intermediate, LAC14, was prepared from TNP-aminocaproyl liposomes sensitized with anti-TNP antibody (Ab) and purified human C1 and C4. LAC14, containing radiolabeled C4, was analyzed by SDS-PAGE followed by autoradiography, and yielded a 210-kDa band
T. Masaki, M. Matsumoto, R. Yasuda, R. Levine, H. Kitamura, T. Seya   +5 more
semanticscholar   +1 more source

How Escherichia coli Circumvent Complement-Mediated Killing

Frontiers in Immunology, 2017
Complement is a crucial arm of the innate immune response against invading bacterial pathogens, and one of its main functions is to recognize and destroy target cells.
Angela S. Barbosa, Afonso G. Abreu, Afonso G. Abreu   +2 more
doaj   +1 more source

Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging

iMeta, Volume 4, Issue 3, June 2025.
Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang, Rong Li, Yasong Liu, Jinliang Liang, Yihang Gong, Cuicui Xiao, Jianye Cai, Tingting Wang, Qiang You, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Yingcai Zhang, Yang Yang, Hua Li, Jia Yao, Qi Zhang, Jun Zheng   +17 more
wiley   +1 more source