Results 51 to 60 of about 110,790 (277)
Stratification of responders towards eculizumab using a structural epitope mapping strategy [PDF]
, 2016 The complement component 5 (C5)-binding antibody eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS).
Berglund, Magnus M. +6 more
core +1 more source
Effect of anti-C5 antibody on recuperation from ischemia/reperfusion-induced acute kidney injury
Renal Failure, 2019 Aim: The complement system is activated in acute kidney injury (AKI). Anti-C5 antibody targets the common terminal portion of the complement cascade that generate the terminal complex C5b-9 and has a renal-protective effect in paroxysmal nocturnal ...
Shani Zilberman-Itskovich +3 more
doaj +1 more source
Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice
Respiratory Research, 2006 Background Previous genetic analysis has shown that a deletion in the complement component 5 gene-coding region renders mice more susceptible to allergen-induced airway hyperresponsiveness (AHR) due to reduced IL-12 production.
Siddiqui Javed +4 more
doaj +1 more source
Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices
Frontiers in Immunology, 2021 Complement activation is key to anti-microbial defenses by directly acting on microbes and indirectly by triggering cellular immune responses. Complement activation may also contribute to the pathogenesis of numerous inflammatory and immunological ...
Sinan Muldur +8 more
doaj +1 more source
Anti-factor B autoantibody in dense deposit disease [PDF]
, 2010 Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis type II, is a rare kidney disorder that is associated with dysregulation of the alternative pathway of complement.
Józsi, Mihály +4 more
core +1 more source
Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
core +2 more sources
Complement C5 Protein as a Marker of Subclinical Atherosclerosis
Journal of the American College of Cardiology, 2020 The mechanisms underlying early atherosclerotic plaque formation are not completely understood. Moreover, plasma biomarkers of subclinical atherosclerosis are lacking.The purpose of this study was to analyze the temporal and topologically resolved protein changes taking place in human aortas with early atherosclerosis to find new potential diagnostic ...
Martínez-López, Diego +17 more
openaire +6 more sources
Complement C5 and Early Oxygen Kinetics during Murine Sepsis [PDF]
Academic Emergency Medicine, 2005 Objectives: Changes in oxygen consumption (VO2) and carbon dioxide production (VCO2) are common but poorly understood features of sepsis. The authors studied the role of complement C5 in the development of abnormal oxygen kinetics during sepsis in mice, arguing that as a pro‐inflammatory event, complement activation might exacerbate disturbances in ...
Valencia, Gabriel +2 more
openaire +3 more sources
Biomedicines, 2022 Introduction: immune-mediated necrotising myopathy (IMNM) is associated with pathogenic anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, at least partly through activation of the classical pathway of ...
Sarah Julien +13 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source