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Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses [PDF]
Molecular Immunology, 2017 Contains fulltext : 177337.pdf (Publisher’s version ) (Open Access)The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 ...
Andreas Barratt-Due +2 more
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Complement C5a Receptor Assay for High Throughput Screening
Journal of Receptor Research, 1991The complement C5a receptor on U937 cells, a human histiocytic lymphoma cell line, stimulated with dibutyryl-cAMP have been stabilized for at least 3 months at a dilute, ready to use concentration. [125I]-Bolton Hunter labeled C5a, (recombinant, human) has been prepared by reverse phase HPLC to 2200 Ci/mmol. Using a filtration binding assay the Kd from
S R, Harris +4 more
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Molecular Immunology, 1994
C5a is a 74 amino acid peptide cleaved from the fifth component of the complement system after activation of either the alternative or classical pathways. It is a potent chemoattractant for neutrophils and monocytes binding to identical receptors on the cell surface.
J E, Pease, D R, Burton, M D, Barker
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C5a is a 74 amino acid peptide cleaved from the fifth component of the complement system after activation of either the alternative or classical pathways. It is a potent chemoattractant for neutrophils and monocytes binding to identical receptors on the cell surface.
J E, Pease, D R, Burton, M D, Barker
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The role of complement component C5a in nociceptive sensitization
2018<p>The complement system is a principal component of innate immunity. Recent studies have underscored the importance of C5a and other complement components in inflammatory and neuropathic pain, although the underlying mechanisms are largely unknown. In particular, it is unclear how the complement system communicates with nociceptors and which ion
Charles A. Warwick +5 more
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Translational Research, 2006
Studies in rodent models suggested that complement may play a critical role in susceptibility to airway hyperresponsiveness (AHR) and as a mediator of bronchial obstruction and inflammation in asthma. Complement may participate in susceptibility to asthma because of an intrinsic abnormality in complement activation and generation of C3a, C5a, or other ...
Sven K, Wust +4 more
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Studies in rodent models suggested that complement may play a critical role in susceptibility to airway hyperresponsiveness (AHR) and as a mediator of bronchial obstruction and inflammation in asthma. Complement may participate in susceptibility to asthma because of an intrinsic abnormality in complement activation and generation of C3a, C5a, or other ...
Sven K, Wust +4 more
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Complement Component C5a Is Integral to the Febrile Response of Mice to Lipopolysaccharide
Neuroimmunomodulation, 2005<i>Objectives:</i> The complement system is critical to the febrile response of mice to intraperitoneally administered lipopolysaccharide (LPS). We previously identified C3 and C5 as two components potentially involved in this response. This study was designed to examine whether the complement system is also pivotal in the response of mice ...
S, Li +4 more
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Complement Regulation in Human Tenocytes under the Influence of Anaphylatoxin C5a
International Journal of Molecular Sciences, 2021Sandeep Silawal +2 more
exaly
Complement C5a Receptors in Hidradenitis Suppurativa
Case Medical Research, 2020openaire +1 more source
The Role of the Complement System and the Activation Fragment C5a in the Central Nervous System
NeuroMolecular Medicine, 2009Peter Gerrard Noakes +2 more
exaly