Results 191 to 200 of about 405,066 (236)

Dengue severity and profiles of complement activation and immune mediators: A multicenter cohort study in Indonesia. [PDF]

PLoS One
Saptarini I, Masyeni S, Harahap AR, Giantini A, Nugroho P, Handito A, Hendarwan H, Susilo A, Haryanto S, Fitriani D, Sasmono RT, Nelwan EJ.   +11 more
europepmc   +1 more source

Complement in acute kidney injury: a convergent pathogenic pathway in multifactorial renal damage. [PDF]

Front Immunol
Yi D, Yang R, Guo Y, Zhou H, Luan J.
europepmc   +1 more source

Complement as a driver of immune-vascular heterogeneity across preeclampsia subtypes: toward a precision medicine framework. [PDF]

Front Immunol
Ge Y, Gao T.
europepmc   +1 more source

Correction to Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR 1) in lupus nephritis: A novel therapeutic target. [PDF]

J Cell Commun Signal
europepmc   +1 more source

Complement component 5a (C5a)

International Journal of Biochemistry and Cell Biology, 2009
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert
Helga Manthey, Trent Woodruff, Peter Monk   +2 more
exaly   +7 more sources

Complement C5a: Impact on the field of veterinary medicine

Veterinary Journal, 2012
Complement C5a is a pro-inflammatory polypeptide produced during activation of the complement cascade in response to foreign antigens or tissue damage secondary to physical or chemical injury. C5a, via activation of the C5a receptor (C5aR or CD88), is a major inflammatory mediator involved in a number of diseases, including some of veterinary relevance.
Barbara Rolfe, P C Mills, P C Mills
exaly   +7 more sources

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Emerging Insights into the Structure and Function of Complement C5a Receptors

Trends in Biochemical Sciences, 2020
Complement factor C5a is an integral constituent of the complement cascade critically involved in the innate immune response, and it exerts its functions via two distinct receptors, C5aR1 and C5aR2. While C5aR1 is a prototypical G-protein-coupled receptor (GPCR), C5aR2 lacks functional coupling to heterotrimeric G proteins, although both receptors ...
Xaria Li, Shubhi Pandey, Trent Woodruff   +2 more
exaly   +6 more sources

Complement C5a inhibition reduces atherosclerosis in ApoE ^–/– mice

The FASEB Journal, 2011
ABSTRACT The complement C5a receptor, CD88, is present on many of the cells found within human atherosclerotic plaques, but little is known about the role of C5a in atherogenesis. Using real‐time PCR, we determined that ApoE –/–
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara, Taylor, Stephen M.   +6 more
openaire   +6 more sources