Results 191 to 200 of about 36,145 (228)

The Role of Complement Component C5a in the Pathogenesis of Diabetic Kidney Disease: A New Kid on the Block? [PDF]

Cureus
Geladari V, Paschou E, Betsikos A, Pallas D, Sabanis N.   +4 more
europepmc   +1 more source

Complement role in kidney disease: a comprehensive review and therapeutic innovations. [PDF]

BMC Nephrol
Cortez Ferreira B, Matos Silva G, Venda J, Afonso N, Leal R, Cerqueira S, Galvão A, Sá H.   +7 more
europepmc   +1 more source

Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyelitis optica from multiple sclerosis. [PDF]

Brain
Furlan R, Schaedelin S, Frederiksen JL, Watanabe M, Isobe N, Piehl F, Fink K, Iacobaeus E, Evertsson B, Khademi M, Gastaldi M, Greco G, Mariotto S, Carta S, Di Sapio A, Bava CI, Giorgi L, Benkert P, Maceski AM, Oechtering J, Willemse E, Pröbstel AK, Pröbstel AK, Pretzsch R, Finardi A, Mandelli A, Anthony DC, Kuhle J, Leppert D.   +28 more
europepmc   +1 more source

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Complement component 5a (C5a)

International Journal of Biochemistry and Cell Biology, 2009
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert
Helga D Manthey, Trent M Woodruff, Peter N Monk   +2 more
exaly   +5 more sources

Function, structure and therapeutic potential of complement C5a receptors [PDF]

British Journal of Pharmacology, 2007
Complement fragment (C)5a is a 74 residue pro‐inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury.
Peter N Monk, David Fairlie
exaly   +6 more sources

Emerging Insights into the Structure and Function of Complement C5a Receptors

Trends in Biochemical Sciences, 2020
Complement factor C5a is an integral constituent of the complement cascade critically involved in the innate immune response, and it exerts its functions via two distinct receptors, C5aR1 and C5aR2. While C5aR1 is a prototypical G-protein-coupled receptor (GPCR), C5aR2 lacks functional coupling to heterotrimeric G proteins, although both receptors ...
Shubhi Pandey, Jagannath Maharana, Xaria X Li   +2 more
exaly   +5 more sources

Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2

Journal of Cellular Biochemistry, 2022
AbstractThe complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments that interacts with a distinct set of complement receptors.
Aurosikha Das, Manaswini Ghosh, Pulkit Kr. Gupta, Soumendra Rana   +3 more
openaire   +2 more sources

Complement C5a: Impact on the field of veterinary medicine

Veterinary Journal, 2012
Complement C5a is a pro-inflammatory polypeptide produced during activation of the complement cascade in response to foreign antigens or tissue damage secondary to physical or chemical injury. C5a, via activation of the C5a receptor (C5aR or CD88), is a major inflammatory mediator involved in a number of diseases, including some of veterinary relevance.
Barbara E Rolfe
exaly   +5 more sources

Involvement of complement peptides C3a and C5a in osteoarthritis pathology

Peptides, 2022
Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five diseases in Germany causing the highest suffering of the patients and cost for the society. The quality of life of OA patients is severely compromised, and adequate therapy is lacking owing to a knowledge gap that acts as a major barrier to finding safe and ...
Nicole, Schäfer, Susanne, Grässel
openaire   +2 more sources

C5L2: a controversial receptor of complement anaphylatoxin, C5a

The FASEB Journal, 2012
C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a single, G‐protein‐coupled, C5a receptor (C5aR; also termed CD88). In 2000, a second C5a receptor, C5L2 (previously known as GPR77), was discovered; yet, despite 12 yr of intensive research, its biological ...
Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M., Woodruff, Trent M.   +4 more
openaire   +5 more sources