Results 201 to 210 of about 405,066 (236)
The effect of complement C5a on mitochondrial functions of PC12 cells
NeuroReport, 2011 C5a is thought to play a role during complement-activated neuronal apoptotic cell death in the central nervous system. The mechanisms responsible are however not well-understood. As mitochondria play a key role during apoptosis, we investigated mitochondria as a potential target for C5a.
Ryan D, Martinus, Christian J, Cook
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Complement C5A regulates prolabor mediators in human placenta.
Biology of reproduction, 2012 Human preterm and term parturition is associated with inflammatory cascades in the uteroplacental unit. Activation of the complement cascade releases potent proinflammatory mediators, including the anaphylatoxin C5a, which exerts its biological effects through its receptors, C5AR (also known as CD88) and C5L2, official symbol GPR77.
Lappas, Martha +3 more
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Complement C5a acts as molecular adjuvant in fish by enhancing antibody response to soluble antigen
Fish and Shellfish Immunology, 2014 C5a, the most potent anaphylatoxin generated during complement activation, has important proinflammatory actions and has also been shown to enhance antigen-specific antibody response in mammals, thereby acting as a molecular adjuvant.
Oriol Sunyer, Yong-An Zhang
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Journal of Cellular Biochemistry, 2022
AbstractThe complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments that interacts with a distinct set of complement receptors.
Aurosikha Das +3 more
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AbstractThe complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments that interacts with a distinct set of complement receptors.
Aurosikha Das +3 more
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Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy [PDF]
Cancer Cell, 2018 Tiziana Cotechini +2 more
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C5L2: a controversial receptor of complement anaphylatoxin, C5a
The FASEB Journal, 2012C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a single, G‐protein‐coupled, C5a receptor (C5aR; also termed CD88). In 2000, a second C5a receptor, C5L2 (previously known as GPR77), was discovered; yet, despite 12 yr of intensive research, its biological ...
Li, Rui +4 more
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Involvement of complement peptides C3a and C5a in osteoarthritis pathology
Peptides, 2022Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five diseases in Germany causing the highest suffering of the patients and cost for the society. The quality of life of OA patients is severely compromised, and adequate therapy is lacking owing to a knowledge gap that acts as a major barrier to finding safe and ...
Nicole, Schäfer, Susanne, Grässel
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Circular dichroism of C5a anaphylatoxin of porcine complement
Biochemical and Biophysical Research Communications, 1974Abstract The far-ultraviolet circular dichroism spectrum of C5a anaphylatoxin of porcine complement implies that it has a substantial content of helical structure. The circular dichroism spectra of C5a in the 200–250 nm region at pH 7.2 and 3.7 are nearly identical and resemble those of C3a anaphylatoxin.
W T, Morgan +2 more
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Immunology & Cell Biology, 2013
Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Croker, Daniel E. +3 more
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Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Croker, Daniel E. +3 more
openaire +5 more sources
Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood
Journal of Neuroimmunology, 2014 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by the progressive loss of motor neurons within the central nervous system.
Susanna Mantovani +2 more
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