Results 191 to 200 of about 11,877 (255)

Bactericidal Membrane Attack Complex formation initiates at the new pole of E. coli

open access: yes
van ‘t Wout MF   +7 more
europepmc   +1 more source

An indel within the C8 alpha subunit of human complement C8 mediates intracellular binding of C8 gamma and formation of C8 alpha-gamma.

Biochemistry, 2000
Human C8 is one of five complement components (C5b, C6, C7, C8, and C9) that interact to form the cytolytic membrane attack complex, or MAC. It is an oligomeric protein composed of three subunits (C8alpha, C8beta, C8gamma) that are products of different genes.
M E, Plumb, J M, Sodetz
openaire   +5 more sources

Genetic polymorphism of complement component C8

Human Genetics, 1985
Extensive genetic polymorphism of complement component C8 was demonstrated by isoelectric focusing of serum or plasma samples followed by immunoblotting procedures. Using these methods, we could detect both alpha-gamma (C81) and beta (C82) chain polymorphisms in the same gel.
S, Rogde   +5 more
openaire   +2 more sources

A familial dysfunction of the eighth component of complement (C8)

Clinical Immunology and Immunopathology, 1980
Abstract A 6-year-old boy, who presented with hepatosplenomegaly, moderately elevated erythrocyte sedimentation rate, hypergammaglobulinemia, and eosinophilia, was found to have very low or undetectable serum C8 hemolytic activity. This activity was restored to normal by the addition of purified C8.
F, Tedesco   +3 more
openaire   +2 more sources

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