Results 201 to 210 of about 11,877 (255)
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The Terminal Complement Complex in Sera Deficient in the Eighth Component of Complement (C8)
Scandinavian Journal of Immunology, 1986The terminal complement complex (TCC) was quantified in sera from patients with a genetic deficiency of C8α‐γ or C8β The individual sera contained only trace amounts of TCC compared with a normal serum pool. The content of TCC increased after mixing the two sera, which was consistent with reconstitution of C8 activity.
T E, Mollnes +3 more
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Genetic basis of human complement C8 beta deficiency
The Journal of Immunology, 1993Abstract The eighth component of human complement (C8) is a serum protein consisting of three chains (alpha, beta, and gamma) and encoded by three different genes, C8A, C8B, and C8G. C8A and C8B are closely linked on chromosome 1p, whereas C8G is located on chromosome 9q.
T, Kaufmann +5 more
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Inhibition of the Eighth Component of Complement (C8) by Ethylenediaminetetra-Acetate (Edta)
The Journal of Immunology, 1970Abstract Functionally pure C8 from human or guinea pig serum was inactivated by 1 to 2 × 10-3 M EDTA. Native C8 in serum was partially inactivated by EDTA, but much longer periods of incubation at 37°C were required for this to be evident.
D R, Schultz, R M, Zarco
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Complement C8 deficiency with recurrent meningococcemia: Examination of meningococcal opsonization
Journal of Paediatrics and Child Health, 1985Abstract A 10 year old girl presented with recurrent febrile episodes over 2 months. A non‐typable strain of Neisseria meningitidis was grown from blood cultures on three occasions. She was found to lack functional C8 activity in serum but material with C8 antigenic activity was present. The opsonic activity of the C8 deficient serum for N. meningidis
A S, Kemp +3 more
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The gamma subunit of the eighth complement component (C8) in rainbow trout
Developmental & Comparative Immunology, 2006Of the 35 proteins, enzymes, receptors and regulatory components of the complement system, C8gamma is unique in that it is the only lipocalin. C8gamma is a subunit of the C8 molecule, which is one of the five components (C5b, C6, C7, C8 and C9) that interact as a consequence of complement activation to form the membrane attack complex.
Anastasios D, Papanastasiou +1 more
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In vitro expression of the beta subunit of human complement component C8
Molecular Immunology, 1996Human C8 is one of five components of the cytolytic C5b-9 complex of complement. It is an oligomeric protein composed of three subunits (alpha, beta, gamma) encoded in separate genes. These are arranged as a disulfide-linked alpha-gamma dimer and a noncovalently associated beta chain.
C S, Letson, K M, Kaufman, J M, Sodetz
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European Journal of Clinical Investigation, 1983
Abstract. A haemolytically inactive alpha‐mobile complement C8 component was identified by crossed immunoelectrophoresis in a 27‐year‐old male with recurrent meningococcal infections and absence of complement mediated serum haemolytic activity. The patient's serum/plasma contained no demonstrable normal C8.
I, Brandslund +6 more
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Abstract. A haemolytically inactive alpha‐mobile complement C8 component was identified by crossed immunoelectrophoresis in a 27‐year‐old male with recurrent meningococcal infections and absence of complement mediated serum haemolytic activity. The patient's serum/plasma contained no demonstrable normal C8.
I, Brandslund +6 more
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The Journal of Immunology, 1979
Abstract Inhibitors of the fluid phase complex were examined in serum from which the lipoproteins had been removed. A limited number of these nonlipoprotein inhibitors were observed, and one was shown to be C8 by several criteria.
G R, Nemerow, K I, Yamamoto, T F, Lint
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Abstract Inhibitors of the fluid phase complex were examined in serum from which the lipoproteins had been removed. A limited number of these nonlipoprotein inhibitors were observed, and one was shown to be C8 by several criteria.
G R, Nemerow, K I, Yamamoto, T F, Lint
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Molecular Immunology, 2020
Complement C8, as a main component of the membrane attack complex, has only been identified in vertebrates. C8 comprises three subunits encoded by individual genes: C8a (alpha chain), C8b (beta chain), and C8g (gamma chain). However, in fish, there have been limited studies on the evolutionary history and systematic function of C8. In the present study,
Lisen, Li +4 more
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Complement C8, as a main component of the membrane attack complex, has only been identified in vertebrates. C8 comprises three subunits encoded by individual genes: C8a (alpha chain), C8b (beta chain), and C8g (gamma chain). However, in fish, there have been limited studies on the evolutionary history and systematic function of C8. In the present study,
Lisen, Li +4 more
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Molecular Immunology, 2002
Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that interact to form the cytolytic membrane attack complex (MAC) on bacterial cell membranes. It is an oligomeric protein composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain.
Chasta L, Parker, James M, Sodetz
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Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that interact to form the cytolytic membrane attack complex (MAC) on bacterial cell membranes. It is an oligomeric protein composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain.
Chasta L, Parker, James M, Sodetz
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