Results 41 to 50 of about 80,611 (190)

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

Frontiers in Immunology, 2022
The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces.
Ayman Khattab, Ayman Khattab, Mikel Rezola, Marta Barroso, Mikael Kyrklund, Mikael Kyrklund, Tero Pihlajamaa, Tobias L. Freitag, Geert-Jan van Gemert, Teun Bousema, Perttu Permi, Perttu Permi, Ossi Turunen, Ossi Turunen, Robert Sauerwein, Adrian J. F. Luty, Seppo Meri, Seppo Meri, Seppo Meri   +18 more
doaj   +1 more source

Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]

, 2017
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín, Ramos Morales, Francisco   +1 more
core   +1 more source

The Borrelia afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning beta-barrel [PDF]

, 2015
The deep evolutionary history of the Spirochetes places their branch point early in the evolution of the diderms, before the divergence of the present day Proteobacteria.
Adam Dyer, Albrecht, Bagos, Barcena-Uribarri, Behera, Bhide, Bordier, Brooks, Bunikis, Cabello, Casjens, Coutte, Crago, Crother, Cullen, Di, Dietrich, Eddy, Eswar, Fairman, Feng, Finn, Fraser, Freeman, Gemma Brown, Gessmann, Greene, Guina, Heffernan, Hong, Jaroszewski, Kenedy, Koebnik, Kopp, Kraiczy, Kurtenbach, Lenhart, Lenka Stejskal, Livengood, Margos, Mertins, Mittal, Nair, Oksi, Ornstein, Ostberg, Paetzel, Pautsch, Petersen, Peter R. Laity, Pettersen, Prasadarao, Preac-Mursic, Pugsley, Pulzova, Richard J. Bingham, Robert, Rogovskyy, Schmidli, Schulz, Setubal, Skare, Sperisen, Steere, Struyve, Sugawara, Svergun, Tamm, Thein, Tilly, Tommassen, Vogt, Volkov, Xie, Yamashita, Yang, Zhang   +76 more
core   +1 more source

Staphylococcal complement evasion by various convertase-blocking molecules [PDF]

The Journal of Experimental Medicine, 2007
To combat the human immune response, bacteria should be able to divert the effectiveness of the complement system. We identify four potent complement inhibitors in Staphylococcus aureus that are part of a new immune evasion cluster. Two are homologues of the C3 convertase modulator staphylococcal complement inhibitor (SCIN) and function in a similar ...
Jongerius, I, Köhl, J, Pandey, M, Ruyken, M, Kessel, v, van Strijp, J, Rooijakkers, S   +6 more
openaire   +2 more sources

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Hammerschmidt, Claudia, Hallström, Teresia, Skerka, Christine, Wallich, Reinhard, Stevenson, Brian, Zipfel, Peter F., Kraiczy, Peter   +6 more
core   +3 more sources

The grand escape – how pathogens outsmart the human complement system

Immunobiology
Infectious diseases remain a significant cause of mortality and morbidity worldwide. Complement is a critical component in the defense against pathogens and despite their great differences, viruses, bacteria, fungi, and protists have all developed ...
A.A. Nowacka, L. Sordo Vieira, V. Petr, B. Fageräng, R. Würzner, M. Ohms   +5 more
doaj   +1 more source

CspA from Borrelia burgdorferi Inhibits the Terminal Complement Pathway

mBio, 2013
In order to survive and persist in an immunocompetent human host, Borrelia burgdorferi controls the human immune attack and blocks the damaging effects of the activated complement system.
Teresia Hallström, Corinna Siegel, Matthias Mörgelin, Peter Kraiczy, Christine Skerka, Peter F. Zipfel   +5 more
doaj   +1 more source

Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo. [PDF]

, 2014
Staphylococcus aureus is a commensal and major pathogen of humans and animals. Comparative genomics of S. aureus populations suggests that colonization of different host species is associated with carriage of mobile genetic elements (MGE), particularly ...
Gould, KA, Lindsay, JA, Lloyd, DH, Loeffler, A, McCarthy, AJ, Witney, AA   +5 more
core   +2 more sources

Novel Evasion Mechanisms of the Classical Complement Pathway [PDF]

The Journal of Immunology, 2016
Abstract Complement is a network of soluble and cell surface-associated proteins that gives rise to a self-amplifying, yet tightly regulated system with fundamental roles in immune surveillance and clearance. Complement becomes activated on the surface of nonself cells by one of three initiating mechanisms known as the classical, lectin,
Brandon L Garcia, Seline A Zwarthoff, Suzan H M Rooijakkers, Brian V Geisbrecht   +3 more
openaire   +2 more sources

Complement evasion strategies of Borrelia burgdorferi sensu lato [PDF]

FEBS Letters, 2020
Borreliosis (Lyme disease) is a spirochetal disease caused by the species complex of Borrelia burgdorferi transmitted by Ixodes spp. ticks. Recorded to be the most common tick‐borne disease in the world, the last two decades have seen an increase in disease incidence and distribution, exceeding 360 000 cases in Europe alone. If untreated, infection may
Vinaya Dulipati, Seppo Meri, Jaana Panelius   +2 more
openaire   +2 more sources