Results 21 to 30 of about 32,418 (239)

Complement evasion by Bordetella pertussis: implications for improving current vaccines [PDF]

Journal of Molecular Medicine, 2015
Ilse Jongerius, Tim J Schuijt, Frits R Mooi   +2 more
exaly   +2 more sources

Phylogenomic Diversity Elucidates Mechanistic Insights into Lyme Borreliae-Host Association

mSystems, 2022
Host association—the selective adaptation of pathogens to specific host species—evolves through constant interactions between host and pathogens, leaving a lot yet to be discovered on immunological mechanisms and genomic determinants.
Matthew Combs, Ashley L. Marcinkiewicz, Alan P. Dupuis, April D. Davis, Patricia Lederman, Tristan A. Nowak, Jessica L. Stout, Klemen Strle, Volker Fingerle, Gabriele Margos, Alexander T. Ciota, Maria A. Diuk-Wasser, Sergios-Orestis Kolokotronis, Yi-Pin Lin   +13 more
doaj   +1 more source

Streptococcus pneumoniae PspC Subgroup Prevalence in Invasive Disease and Differences in Contribution to Complement Evasion. [PDF]

Infect Immun, 2018
The pneumococcal capsular serotype is an important determinant of complement resistance and invasive disease potential, but other virulence factors have also been found to contribute.
van der Maten E, van den Broek B, de Jonge MI, Rensen KJW, Eleveld MJ, Zomer AL, Cremers AJH, Ferwerda G, de Groot R, Langereis JD, van der Flier M.   +10 more
europepmc   +3 more sources

Protein engineering to target complement evasion in cancer. [PDF]

FEBS Lett, 2014
The complement system is composed of soluble factors in plasma that enhance or “complement” immune-mediated killing through innate and adaptive mechanisms.
Carter D, Lieber A.
europepmc   +2 more sources

Expression of Rickettsia Adr2 protein in E. coli is sufficient to promote resistance to complement-mediated killing, but not adherence to mammalian cells.

PLoS ONE, 2017
Bacteria exposed to host serum are subject to the antibacterial effects to the complement system. However, pathogenic microorganisms have evolved mechanisms of evading this immune attack. We have previously demonstrated that at least two R.
Daniel A Garza, Sean P Riley, Juan J Martinez   +2 more
doaj   +1 more source

Novel method for detecting complement C3 deposition on Staphylococcus aureus

Scientific Reports, 2022
The primary host response to Staphylococcus aureus infection occurs via complement. Complement is an elegant evolutionarily conserved system, playing essential roles in early defences by working in concert with immune cells to survey, label and destroy ...
Toska Wonfor, Shuxian Li, Rhys W. Dunphy, Alex Macpherson, Jean van den Elsen, Maisem Laabei   +5 more
doaj   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
core   +1 more source

Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection

Frontiers in Immunology, 2021
The complement system is designed to recognise and eliminate invading pathogens via activation of classical, alternative and lectin pathways. Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that leads ...
Praveen M. Varghese, Praveen M. Varghese, Shuvechha Mukherjee, Futwan A. Al-Mohanna, Souad M. Saleh, Fahad N. Almajhdi, Nazar Beirag, Saad H. Alkahtani, Reena Rajkumari, Beatrice Nal Rogier, Robert B. Sim, Susan Idicula-Thomas, Taruna Madan, Valarmathy Murugaiah, Uday Kishore   +14 more
doaj   +1 more source

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
core   +1 more source

The mechanisms of eluding of herpesvirus from complement system

Zdorovʹe Rebenka, 2013
The article presents the basic mechanisms of the complement system, and outlines strategies of evasion of herpesvirus complement-mediated destruction.
Ye.А. Kruger
doaj   +1 more source