Results 41 to 50 of about 505,979 (246)

Complement Attack against Aspergillus and Corresponding Evasion Mechanisms

Interdisciplinary Perspectives on Infectious Diseases, 2012
Invasive aspergillosis shows a high mortality rate particularly in immunocompromised patients. Perpetually increasing numbers of affected patients highlight the importance of a clearer understanding of interactions between innate immunity and fungi ...
Cornelia Speth, Günter Rambach
doaj   +1 more source

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

Frontiers in Microbiology, 2016
The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh, Elise Sofie Hovingh, Bryan van den Broek, Ilse Jongerius, Ilse Jongerius   +4 more
doaj   +1 more source

Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions

Frontiers in Immunology, 2022
Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host innate immune system, including the complement cascade. The Lyme disease spirochete, Borreliella burgdorferi, has evolved numerous outer membrane lipoproteins ...
Charles E. Booth, Alexandra D. Powell-Pierce, Jon T. Skare, Brandon L. Garcia   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Complement system in dermatological diseases – fire under the skin

Frontiers in Medicine, 2015
The complement system plays a key role in several dermatological diseases. Overactivation, deficiency or abnormality of the control proteins are often related to a skin disease.
Jaana Helena Panelius, Jaana Helena Panelius, Seppo Kalevi Meri, Seppo Kalevi Meri, Seppo Kalevi Meri   +4 more
doaj   +1 more source

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Viruses, 2021
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter

Communications Biology, 2022
Edwardsiella tarda TraT promotes cellular infection and serves as an anti-complement factor, shedding light on the mechanisms of E. tarda’s strong evasion of killing by the host.
Mofei Li, Meng Wu, Yuanyuan Sun, Li Sun
doaj   +1 more source

A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway

Virulence, 2023
Streptococcus equi subsp. zooepidemicus (SEZ) is a major equine pathogen that causes pneumonia, abortion, and polyarthritis. It can also cause invasive infections in humans.
René Bergmann, Wieland Schroedl, Uwe Müller, Christoph Georg Baums   +3 more
doaj   +1 more source