Results 31 to 40 of about 32,418 (239)

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]

, 2010
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Peter F. Zipfel, Dam, A.P. van, Schuijt, Tim J., Kraiczy, Peter, Nathalie D. van Burgel, Nathalie D. van Burgel, van Dam, Alje P., van Burgel Nathalie D, Burgel, N.D. van, Burgel, Nathalie D. van, Schuijt Tim J, Tim J. Schuijt, Kraiczy Peter, Schuijt, T.J., van Dam Alje P, Zipfel Peter F, Kraiczy, P., Zipfel, Peter F., Alje P. van Dam, Peter Kraiczy, Zipfel, P.F., Dam, Alje P. van, van Burgel, Nathalie D.   +22 more
core   +1 more source

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Nature Communications, 2021
Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact ...
Lin-Ping Wu, Mario Ficker, Jørn B. Christensen, Dmitri Simberg, Panagiotis N. Trohopoulos, Seyed M. Moghimi   +5 more
doaj   +1 more source

Entamoeba histolytica Develops Resistance to Complement Deposition and Lysis after Acquisition of Human Complement-Regulatory Proteins through Trogocytosis

mBio, 2022
Entamoeba histolytica is the cause of amoebiasis. The trophozoite (amoeba) form of this parasite is capable of invading the intestine and can disseminate through the bloodstream to other organs.
Hannah W. Miller, Tammie S. Y. Tam, Katherine S. Ralston   +2 more
doaj   +1 more source

Hide and seek: how Lyme disease spirochetes overcome complement attack

Frontiers in Immunology, 2016
Overcoming the first line of the innate immune system is a general hallmark of pathogenic microbes to avoid recognition and to enter the human host.
Peter Kraiczy
doaj   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
core   +1 more source

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

Frontiers in Immunology, 2022
The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces.
Ayman Khattab, Ayman Khattab, Mikel Rezola, Marta Barroso, Mikael Kyrklund, Mikael Kyrklund, Tero Pihlajamaa, Tobias L. Freitag, Geert-Jan van Gemert, Teun Bousema, Perttu Permi, Perttu Permi, Ossi Turunen, Ossi Turunen, Robert Sauerwein, Adrian J. F. Luty, Seppo Meri, Seppo Meri, Seppo Meri   +18 more
doaj   +1 more source

Complement in malaria : immune evasion strategies and role in protective immunity [PDF]

, 2020
The malaria parasite has for long been thought to escape host complement attack as a survival strategy. However, it was only recently that complement evasion mechanisms of the parasite were described.
Kiyuka, Patience Kerubo, Ayman Khattab, Patience Kerubo Kiyuka, Meri, Seppo, Seppo Meri, Khattab, Ayman   +5 more
core   +1 more source

The impact of complement evasion on transmission of malaria

, 2022
S.243As part of the innate immune system, human complement is a first line of defence against microbial invaders. However, microbes can evade complement recognition by binding to regulator proteins that normally protect host cells from complement ...
Lasonder, E., Skerka, C., Simon, N., Fischer, R., Scheuermayer, M., Pradel, G., Zipfel, P., Kühn, A.   +7 more
core   +1 more source

The grand escape – how pathogens outsmart the human complement system

Immunobiology
Infectious diseases remain a significant cause of mortality and morbidity worldwide. Complement is a critical component in the defense against pathogens and despite their great differences, viruses, bacteria, fungi, and protists have all developed ...
A.A. Nowacka, L. Sordo Vieira, V. Petr, B. Fageräng, R. Würzner, M. Ohms   +5 more
doaj   +1 more source

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch   +17 more
core   +1 more source