Results 61 to 70 of about 80,611 (190)

Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System. [PDF]

, 2020
The capsule is the dominant Streptococcus pneumoniae virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected relationship between mutation of adcAII, which encodes a zinc uptake ...
Arioli, Bayle, Bentley, Brown, Brown, Brown, Brown, Dintilhac, Domenech, Domenech de Cellès, Donini, Eijkelkamp, Faille, Geno, Giammarinaro, Giefing-Kröll, Gillespie, Hammerschmidt, Hathaway, Henrichsen, Hyams, Hyams, James, Johnston, Junges, Kietzman, Kim, Kim, Kohler, Li, Loisel, Loisel, Manso, Morona, Nelson, Oggioni, Oliver, Plumptre, Rowland, Sanchez, Sanchez, Schaffner, Trappetti, Ulijasz, Ventura, Weiser, Wilson, Wilson, Wu, Yadav, Yahiaoui, Yother   +51 more
core   +4 more sources

Audit Certainty, Audit Productivity, and Taxpayer Compliance [PDF]

, 2005
Strategies for dealing with evasion include such standard policies as stricter enforcement (e.g., increased audit rates, more extensive audits, larger penalties). However, the exact responses of taxpayers to these enforcement measures are quite difficult
James R. Alm, Michael McKee
core   +1 more source

Incorporation of Host Complement Regulatory Proteins into Newcastle Disease Virus Enhances Complement Evasion [PDF]

Journal of Virology, 2012
ABSTRACTNewcastle disease virus (NDV), an avian paramyxovirus, is inherently tumor selective and is currently being considered as a clinical oncolytic virus and vaccine vector. In this study, we analyzed the effect of complement on the neutralization of NDV purified from embryonated chicken eggs, a common source for virus production. Fresh normal human
Moanaro, Biswas, John B, Johnson, Sandeep R P, Kumar, Griffith D, Parks, Subbiah, Elankumarana, Elankumaran, Subbiah   +5 more
openaire   +3 more sources

A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family [PDF]

The Journal of Immunology, 2009
Abstract Staphylococcus aureus possesses an impressive arsenal of complement evasion proteins that help the bacterium escape attack of the immune system. The staphylococcal complement inhibitor (SCIN) protein exhibits a particularly high potency and was previously shown to block complement by acting at the level of the C3 convertases ...
Ricklin, Daniel, Tzekou, Apostolia, Garcia, Brandon L., Hammel, Michal, McWhorter, William J., Sfyroera, Georgia, Wu, You-Qiang, Holers, V. Michael, Herbert, Andrew P., Barlow, Paul N., Geisbrecht, Brian V., Lambris, John D.   +11 more
openaire   +3 more sources

Clonal Diversity, Antibiotic Resistance, and Virulence Factor Prevalence of Community Associated Staphylococcus aureus in Southeastern Virginia

Pathogens, 2023
Staphylococcus aureus is a significant human pathogen with a formidable propensity for antibiotic resistance. Worldwide, it is the leading cause of skin and soft tissue infections (SSTI), septic arthritis, osteomyelitis, and infective endocarditis ...
Katelyn D. Cranmer, Mohan D. Pant, Suzanne Quesnel, Julia A. Sharp   +3 more
doaj   +1 more source

Novel insights into host-fungal pathogen interactions derived from live-cell imaging [PDF]

, 2015
Acknowledgments The authors acknowledge funding from the Wellcome Trust (080088, 086827, 075470 and 099215) including a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377 and FP7-2007–2013 grant agreement HEALTH-F2-2010 ...
A Casadevall, AK Neumann, B Amulic, B Enjalbert, B Hube, BN Gantner, C Jiménez-López, C Sasse, C Tokarski, CC Sheth, CF Urban, CGJ McKenzie, CJ Chrisman, D Armstrong-James, D Ermert, D Liebl, D Vijayan, DA Silva da, DC Savage, DJ Krysan, E Moreno-Ruiz, EK Szabo, FM Rudkin, G Chamilos, G Vande Velde, GD Brown, GD Brown, H Ma, H Ma, I Rubin-Bejerano, IE Frohner, J Behnsen, J Chandra, J Maertens, J Perlroth, J Voigt, JM Bain, JM Tam, Judith Bain, K Konig, K Schäfer, K Seider, KM Brothers, L Romani, L Romani, Lars-Peter Erwig, LE Lewis, LE Lewis, LG Tilney, LY Ngo, M Alvarez, MC Lorenz, MG Netea, MJ Patterson, MS Lionakis, MS Lionakis, N Papon, NAR Gow, Neil A. R. Gow, O Uzun, O Zaragoza, P Martino, P Miramón, Q Qian, R García-Rodas, RA Drummond, RD Diamond, RI Lehrer, S Bruns, S El-Kirat-Chatel, S Keppler-Ross, S Mitra, SA Johnston, SC Cheng, SE Heinsbroek, V Aimanianda, Wellington, Y Luo   +77 more
core   +1 more source

Complement system in dermatological diseases – fire under the skin

Frontiers in Medicine, 2015
The complement system plays a key role in several dermatological diseases. Overactivation, deficiency or abnormality of the control proteins are often related to a skin disease.
Jaana Helena Panelius, Jaana Helena Panelius, Seppo Kalevi Meri, Seppo Kalevi Meri, Seppo Kalevi Meri   +4 more
doaj   +1 more source

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Viruses, 2021
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore   +5 more
doaj   +1 more source

Protease-dependent mechanisms of complement evasion by bacterial pathogens [PDF]

bchm, 2012
Abstract The human immune system has evolved a variety of mechanisms for the primary task of neutralizing and eliminating microbial intruders. As the first line of defense, the complement system is responsible for rapid recognition and opsonization of bacteria, presentation to phagocytes and bacterial cell killing by direct lysis.
Michal Potempa, Jan Potempa
openaire   +3 more sources

A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway

Virulence, 2023
Streptococcus equi subsp. zooepidemicus (SEZ) is a major equine pathogen that causes pneumonia, abortion, and polyarthritis. It can also cause invasive infections in humans.
René Bergmann, Wieland Schroedl, Uwe Müller, Christoph Georg Baums   +3 more
doaj   +1 more source