Results 251 to 260 of about 392,488 (288)

Preliminary Crystallographic Studies on Human Complement Pro-factor D

Journal of Molecular Biology, 1994
The recombinant zymogen of the human complement protein factor D has been crystallized. Crystals were grown by vapor diffusion using polyethylene glycol 6000 as precipitant. Two crystal forms obtained at pH 5.4 belong to space group P2(1). The crystals grow to dimensions of 0.6 mm x 0.3 mm x 0.3 mm in three days, are stable in the X-ray beam, and ...
S V, Narayana, Y, Yamauchi, K J, Macon, D, Moore, L J, DeLucas, J E, Volanakis   +5 more
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A monoclonal antibody which blocks the function of factor D of human complement

Journal of Immunological Methods, 1990
Factor D is an essential enzyme for activation of complement by the alternative pathway (AP). It has been difficult to obtain mouse monoclonal antibodies (Mabs) which block the function of factor D. We have developed a strategy to obtain such Mabs using a double screening procedure of the initial clones.
Pascual M, Catana E, Spertini F, Macon K, Volanakis JE, Schifferli JA   +5 more
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Mutational Analysis of the Substrate Binding Site of Human Complement Factor D

Biochemistry, 1994
Complement factor D is a serine protease with a single natural substrate, C3b-complexed factor B, and very low catalytic activity against synthetic esters. The recently solved X-ray crystal structure of factor D has demonstrated certain key differences from other serine protease in the conformation of residues of the catalytic triad and the substrate ...
S, Kim, S V, Narayana, J E, Volanakis
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Significant Reduction of Factor D and Immunosuppressive Complement Fragment Ba by Hemofiltration

Blood Purification, 2008
Because of their effect on the immune response, especially in patients with chronic or acute renal failure, factor D (FD) and the immunosuppressive complement fragment Ba are substances which may be important for the immunological status. Since they cannot be eliminated by conventional Cuprophan hemodialysis because of their high molecular weight (24 ...
J P, Kaiser, M, Oppermann, O, Götze, R, Deppisch, H, Göhl, G, Asmus, B, Röhrich, D, von Herrath, K, Schaefer   +8 more
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Crystallization and preliminary X-ray investigation of factor D of human complement

Journal of Molecular Biology, 1991
Human factor D, an essential enzyme of the alternative pathway of complement activation, has been crystallized. Crystals were grown by vapor diffusion using polyethylene glycol 6000 and NaCl as precipitants. The factor D crystals are triclinic and the space group is P1 with unit cell dimensions a = 40.8 A, b = 64.7 A, c = 40.3 A, alpha = 101.0 degrees,
S V, Narayana, J M, Kilpatrick, O, el-Kabbani, Y S, Babu, C E, Bugg, J E, Volanakis, L J, DeLucas   +6 more
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Adipsin and Complement Factor D Activity: An Immune-Related Defect in Obesity

Science, 1989
Adipsin is a serine protease that is secreted by adipocytes into the bloodstream; it is deficient in several animal models of obesity, representing a striking example of defective gene expression in this disorder. Recombinant mouse adipsin was purified and its biochemical and enzymatic properties were studied in order to elucidate the ...
B S, Rosen, K S, Cook, J, Yaglom, D L, Groves, J E, Volanakis, D, Damm, T, White, B M, Spiegelman   +7 more
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Complement factor D in uremia.

The New England journal of medicine, 1985
G, Sturfelt, L, Truedsson, A, Sjöholm
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[Factor D of complement: Uremic toxin?].

Nephrologie, 1992
Factor D is an essential enzyme of the alternative pathway of complement. Its catabolism is mainly renal. The concentration of factor D increases with renal failure, and is approximately 10-fold higher in patients with end-stage renal disease. The accumulation of factor D is responsible for an enhancement of alternative pathway activation. Whether this
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Functional deficiency of complement factor D in a monozygous twin.

Clinical and experimental immunology, 1985
An adult twin with recurrent bacterial infections was found to have a partial functional deficiency of complement factor D. Full restoration of alternative pathway activity and zymosan- or cobra venom factor-induced consumption of C3 and B was found after reconstitution of patient's serum with purified D.
H C, Kluin-Nelemans, H, van Velzen-Blad, H P, van Helden, M R, Daha   +3 more
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Oral complement factor D inhibitor danicopan for paroxysmal nocturnal hemoglobinuria

Expert Review of Clinical Pharmacology
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by episodic hemolysis, with additional clinical manifestations including thrombosis and bone marrow failure. The US FDA approved a complement factor D inhibitor, danicopan (Voydeya™), previously known as ACH-4471, for the treatment of extravascular hemolysis in ...
Bo Xu, Jiecan Zhou
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