Results 51 to 60 of about 1,227,803 (177)

Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?

Haseki Tıp Bülteni, 2020
Aim:Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (
Sacide Pehlivan, Mazlum Serdar Akaltun, Mustafa Pehlivan, Savaş Gürsoy, Ayşe Feyda Nursal   +4 more
doaj   +1 more source

Anesthetic management of living donor liver transplantation for complement factor H deficiency hemolytic uremic syndrome: a case report [PDF]

Korean Journal of Anesthesiology, 2014
We experienced a living donor liver transplantation for a 26-month-old girl with complement factor H deficiency. Complement factor H is a plasma protein that regulates the activity of the complement pathway.
Suk-Hee Park, Gaab-Soo Kim
doaj   +1 more source

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Frontiers in Immunology, 2021
Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider, Mihály Józsi, Mihály Józsi   +7 more
doaj   +1 more source

Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice [PDF]

Kidney International, 2010
Total deficiency of complement factor H (CFH) is associated with dense deposit disease and atypical hemolytic uremic syndrome. CFH is the major regulator of the alternative pathway of complement activation and its complete deficiency results in uncontrolled C3 activation through this pathway and secondary C3 deficiency.
Fakhouri, Fadi, de Jorge, Elena Goicoechea, Brune, Frédérique, Azam, Philippe, Cook, H. Terence, Pickering, Matthew C.   +5 more
openaire   +2 more sources

Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H [PDF]

Clinical and Experimental Immunology, 2007
SummaryOTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW SERIES ON COMPLEMENT FACTOR HStructural and functional correlations for factor H. Clin Exp Immunol 2008; 151: doi:10.1111/j.1365-2249.2007.03553.xTherapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative ...
Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena   +1 more
openaire   +3 more sources

Planar posets have dimension at most linear in their height

, 2017
We prove that every planar poset $P$ of height $h$ has dimension at most $192h + 96$. This improves on previous exponential bounds and is best possible up to a constant factor.
Joret, Gwenaël, Micek, Piotr, Wiechert, Veit   +2 more
core   +1 more source

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Frontiers in Immunology, 2018
The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma.
Eija Nissilä, Pipsa Hakala, Katarzyna Leskinen, Angela Roig, Shahan Syed, Kok P. M. Van Kessel, Jari Metso, Carla J. C. De Haas, Päivi Saavalainen, Seppo Meri, Angeliki Chroni, Jos A. G. Van Strijp, Katariina Öörni, Matti Jauhiainen, T. Sakari Jokiranta, Karita Haapasalo   +15 more
doaj   +1 more source

Interaction of complement factor h and fibulin3 in age-related macular degeneration. [PDF]

PLoS ONE, 2013
Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch's membrane basal to the retinal pigment epithelium (RPE).
M Keith Wyatt, Jen-Yue Tsai, Sanghamitra Mishra, Maria Campos, Cynthia Jaworski, Robert N Fariss, Steven L Bernstein, Graeme Wistow   +7 more
doaj   +1 more source

Mouse Podocyte Complement Factor H [PDF]

Journal of the American Society of Nephrology, 2007
Complement factor H (Cfh) is a key plasma protein in humans and animals that serves to limit alternative pathway complement activation in plasma, as well as in local sites such as capillaries of the glomerulus and eye. It was shown that rodent Cfh on platelets is the functional analogue to human erythrocyte complement receptor 1 with a role that is ...
Jessy J, Alexander, Ying, Wang, Anthony, Chang, Alexander, Jacob, Andrew W M, Minto, Menaka, Karmegam, Mark, Haas, Richard J, Quigg   +7 more
openaire   +2 more sources

Anti-factor B autoantibody in dense deposit disease [PDF]

, 2010
Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis type II, is a rare kidney disorder that is associated with dysregulation of the alternative pathway of complement.
Józsi, Mihály, Papp, Krisztián, Prechl, József, Strobel, S., Zimmering, M.   +4 more
core   +1 more source