Results 51 to 60 of about 2,642,556 (405)

Mycoplasma hyopneumoniae evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu)

Virulence, 2020
Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we
Yanfei Yu, Jia Wang, Rui Han, Li Wang, Lei Zhang, Amy Yimin Zhang, Jiuqing Xin, Shaoli Li, Yanhua Zeng, Guoqing Shao, Zhixin Feng, Qiyan Xiong   +11 more
doaj   +1 more source

Complement factor H levels in steady state sickle cell anaemia [PDF]

, 2017
Objective: The red cell membrane of sickle cell anaemia is vulnerable to attack from the alternative complement pathway. The activation of the alternative complement pathway is initiated by externalization of  phosphatidylserine on red cell membrane ...
Ajiboye, A.O., Aworinde, O.O., Edward, G.H., Fasola, F.A., Olufemi-Aworinde, K.J., Olutogun, T.A.   +5 more
core   +2 more sources

Factor H family proteins and human diseases [PDF]

, 2008
Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins.
Abrera-Abeleda, Anderson, Appel, Behnsen, Caswell, Coffey, Corbett, Cordes, Crabb, Dragon-Durey, Ferreira, Gold, Hageman, Hageman, Hammerschmidt, Haupt, Heinen, Hellwage, Hellwage, Hellwage, Hughes, Høgåsen, Jokiranta, Józsi, Józsi, Józsi, Józsi, Kavanagh, Klein, Kotarsky, Kotarsky, Kraiczy, Kunert, Laine, Lambris, Licht, Manuelian, Markiewski, McArthur, McDowell, McRae, Mihály Józsi, Montalvo, Monteferrante, Murphy, Ngampasutadol, Noris, Nozaki, Närkiö-Mäkelä, Oppermann, Pandiripally, Park, Peter F. Zipfel, Pickering, Pickering, Prodinger, Ren, Rodríguez de Córdoba, Skerka, Skerka, Stevenson, Timmann, Venables, Verma, Vik, Walport, Yates, Zipfel, Zipfel, Zipfel   +69 more
core   +1 more source

Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions

Computational and Structural Biotechnology Journal, 2023
Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable.
Natalia Ruiz-Molina, Juliana Parsons, Eva L. Decker, Ralf Reski   +3 more
doaj  

Anesthetic management of living donor liver transplantation for complement factor H deficiency hemolytic uremic syndrome: a case report [PDF]

Korean Journal of Anesthesiology, 2014
We experienced a living donor liver transplantation for a 26-month-old girl with complement factor H deficiency. Complement factor H is a plasma protein that regulates the activity of the complement pathway.
Suk-Hee Park, Gaab-Soo Kim
doaj   +1 more source

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Frontiers in Immunology, 2021
Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider, Mihály Józsi, Mihály Józsi   +7 more
doaj   +1 more source

Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells [PDF]

, 2009
Intrarenal complement activation plays an important role in the progression of chronic kidney disease. A key target of the activated complement cascade is the proximal tubule, a site where abnormally filtered plasma proteins and complement factors ...
Abbate, Mauro, Buelli, Simona, Moioli, Daniela, Morigi, Marina, Noris, Marina, Pusey, Charles D., Remuzzi, Giuseppe, Zanchi, Cristina, Zipfel, Peter F., Zoja, Carla   +9 more
core   +1 more source

The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H

Frontiers in Microbiology, 2015
The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e. rough
Rauna eRiva, Timo K. Korhonen, Seppo eMeri   +2 more
doaj   +1 more source

Interaction of complement factor h and fibulin3 in age-related macular degeneration. [PDF]

PLoS ONE, 2013
Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch's membrane basal to the retinal pigment epithelium (RPE).
M Keith Wyatt, Jen-Yue Tsai, Sanghamitra Mishra, Maria Campos, Cynthia Jaworski, Robert N Fariss, Steven L Bernstein, Graeme Wistow   +7 more
doaj   +1 more source

Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?

Haseki Tıp Bülteni, 2020
Aim:Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (
Sacide Pehlivan, Mazlum Serdar Akaltun, Mustafa Pehlivan, Savaş Gürsoy, Ayşe Feyda Nursal   +4 more
doaj   +1 more source