Results 71 to 80 of about 1,235,428 (322)

Induction of chromosome shattering by ultraviolet light and caffeine: The influence of different distributions of photolesions [PDF]

, 1986
Cells of synchonized and of asynchronously growing cultures of a V79 Chinese hamster line were microirradiated with a low poweer laser-UV-microbeam of wavelength 257 nm.
Barranco, Brenner, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, González-Fernández, Hens, Kihlman, Kihlman, Kihlman, Kihlman, Lau, Lehmann, Moreno, Nilsson, Painter, Painter, Raith, Rappold, Roberts, Schardin, Sedgwick, Setlow, Stack, Steward, Tatsumi, Tobey, Tomulin, Zorn, Zorn   +42 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

POS0047 THE COMPLEMENT FACTOR H-RELATED PROTEIN-5 EXACERBATES PATHOLOGICAL BONE FORMATION OF ANKYLOSING SPONDYLITIS [PDF]

, 2023
Chang‐Nam Son, Jaejoon Lee, Sungsin Jo, Il‐Hoon Sung, T. H. Kim   +4 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement [PDF]

, 2004
The complement system is important in immunosurveillance against tumors. However, malignant cells are usually resistant to complement-mediated lysis. In this study, we examine the expression of factor H, an inhibitor of complement activation, and factor ...
Ajona, D. (Daniel), Castaño, Z. (Z.), Cuttitta, F. (Frank), Garayoa, M. (Mercedes), Martinez, A. (Alfredo), Montuenga-Badia, L.M. (Luis M.), Pajares, M.J. (María José), Pio, R. (Rubén), Zudaire, E. (Enrique)   +8 more
core  

Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. [PDF]

, 2014
The alternative pathway of complement is implicated in the pathogenesis of several renal diseases, such as atypical hemolytic uremic syndrome, dense deposit disease and other forms of C3 glomerulopathy.
Józsi, Mihály, Lopez-Trascasa, M., Nozal, P., Prohászka, Zoltán, Reuter, S., Sanchez-Corral, P., Uzonyi, Barbara   +6 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings [PDF]

, 2011
Characterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or ...
Apic G., Barlow P. N., Barlow P. N., Bernadó P., Bertini I., Bertini I., Bertini I., Bork P., Chen K., Clore G. M., Clore G. M., Clore G. M., Cornilescu G., Delaglio F., DiScipio R. G., Ekman D., Fernando A. N., Ferreira V. P., Furtado P. B., Garrett D. S., Gordon D. L., Henderson C. E., Hocking H. G., Hoebe K., Hourcade D., Janssen B. J. C., Kirkitadze M. D., Kirkitadze M. D., Kirkitadze M. D., Kirkitadze M. D., Lachmann P. J., Lakomek N.-A., Laskowski R. A., Lipari G., Litman G. W., Longinetti M., Losonczi J., Mateusz Maciejewski, McRee D. E., Meiler J., Morgan H. P., Nico Tjandra, Norman D. G., Okemefuna A. I., Okemefuna A. I., Ottiger M., Paul N. Barlow, Reid K., Ricklin D., Schmidt C. Q., Schwieters C. D., Schwieters C. D., Soares D. C., Soares D. C., Tjandra N., Tolman J. R., Ulrich E. L., Vranken W. F., Walport M. J., Weisman H. F., Wu J.   +60 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Complement factor H gene polymorphisms and vivax malaria associated thrombotic microangiopathy

Saudi Journal of Kidney Diseases and Transplantation, 2019
Acute kidney injury (AKI) occurs in about 1% of cases of malaria; however, in these cases, the mortality rate can be as high as 45%. Thrombotic microangiopathy (TMA) as a cause of AKI in malaria is rare with only a handful cases documented in literature ...
Parimal Agrawal, Ashwani Kumar, Amber Parwaiz, Amit Rawat, Karalanglin Tiewsoh, Ritambhra Nada   +5 more
doaj   +1 more source