Results 81 to 90 of about 1,227,803 (177)

Functional Characterization of the Disease-Associated N-Terminal Complement Factor H Mutation W198R

Frontiers in Immunology, 2017
Dysregulation of the complement alternative pathway is involved in the pathogenesis of several diseases, including the kidney diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Marcell Cserhalmi, Barbara Uzonyi, Nicolas S. Merle, Dorottya Csuka, Edgar Meusburger, Karl Lhotta, Zoltán Prohászka, Zoltán Prohászka, Mihály Józsi   +8 more
doaj   +1 more source

Factor H-related proteins determine complement-activating surfaces [PDF]

Trends in Immunology, 2015
Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation. Because FHRs are evolutionarily and structurally related to complement inhibitor factor H (FH), the initial assumption was that the FHRs are also
Józsi, Mihály, Tortajada, A., Uzonyi, Barbara, Goicoechea de, Jorge E., Rodriguez de Cordoba, S.   +4 more
openaire   +4 more sources

Association between plasma complement factor H concentration and clinical outcomes in patients with sepsis

Acute Medicine & Surgery, 2021
Aim The complement system is important for defending against pathogens, however, excessive complement activation is associated with a poor prognosis and organ dysfunction in sepsis.
Junji Shimizu, Kazunori Fujino, Toshihiro Sawai, Yasuyuki Tsujita, Takahisa Tabata, Yutaka Eguchi   +5 more
doaj   +1 more source

Complement factor h-antibody-associated hemolytic uremic syndrome: pathogenesis, clinical presentation, and treatment. [PDF]

, 2014
The presence of circulating autoantibodies, primarily to complement factor H antibodies (CFH-Abs) in plasma characterizes the autoimmune form of atypical hemolytic uremic syndrome (aHUS).
Giner, T., Hofer, J., Józsi, Mihály
core   +1 more source

Measurements of complement factor H-related protein (BTA-TRAK (TM) assay) and nuclear matrix protein (NMP22 assay) - Useful diagnostic tools in the diagnosis of urinary bladder cancer? [PDF]

, 2003
Between 1997 and 2000 we investigated in a prospective study the voided urine samples of all consecutive patients undergoing cystoscopy independent from their clinical background (n=705) with the BTA-TRAK(TM) assay (Bard Diagnostics, Redmont, USA ...
Hofmann, Karin, Holdenrieder, Stefan, Kriegmair, Martin, Mahnert, Brigitte, Nagel, Dorothea, Reiter, Wolfgang, Schmeller, Nikolaus, Stieber, Petra, Tauber, Stephan   +8 more
core   +1 more source

Localization of complement factor H gene expression and protein distribution in the mouse outer retina. [PDF]

, 2015
To determine the localization of complement factor H (Cfh) mRNA and its protein in the mouse outer retina.Quantitative real-time PCR (qPCR) was used to determine the expression of Cfh and Cfh-related (Cfhr) transcripts in the RPE/choroid.
Estep, Jason, Gong, Qizhi, Hjelmeland, Leonard M, Nguyen, Anthony T, Oltjen, Sharon L, Radu, Roxana A, Smit-McBride, Zeljka   +6 more
core   +1 more source

Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage [PDF]

, 2014
BACKGROUND: Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage.
Atsuko Hisada, Daisuke Honda, Hiroyuki Inoshita, Hiyori Suzuki, Isao Ohsawa, Mamiko Shimamoto, Nobuyuki Sato, Satoshi Horikoshi, Seiji Nagamachi, Yasuhiko Tomino, Yoshio Shimizu   +10 more
core   +1 more source

Complement factor H

, 2012
Complement factor H (fH) is a single chain plasma glycoprotein (approximately 150 kDa in size), with 20 domains termed complement control protein (CCP) domains or short consensus repeats (SCR). The complement factor H gene (CFH) is located on chromosome 1q32 in the regulators of complement activation (RCA) gene cluster, adjacent to the genes that code ...
Dinasarapu, Ashok Reddy, Chandrasekhar, Anjana, Jozsi, Mihaly, Subramaniam, Shankar   +3 more
openaire   +1 more source

Complement system biomarkers in first episode psychosis [PDF]

, 2019
Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta, Gaughran, Fiona, Kopczynska, Maja, Mondelli, Valeria, Morgan, B. Paul, Murray, Robin, O'Donovan, Michael, Touchard, Samuel, Zelek, Wioleta   +8 more
core   +2 more sources

The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring

Frontiers in Immunology
Fibroproliferative cutaneous pathologies such as hypertrophic scars and keloids have a high prevalence after burns and surgical interventions; however, their pathophysiology remains not fully understood.
Ilja L. Kruglikov, Katarzyna Walendzik, Philipp E. Scherer   +2 more
doaj   +1 more source