Results 61 to 70 of about 96,307 (191)

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes [PDF]

, 2017
C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular hemolysis ...
A Hill, A Hill, A Nicholson-Weller, A Roth, AM Risitano, AM Risitano, AM Risitano, AM Risitano, AM Risitano, Antonio M. Risitano, B Nilsson, CE Schoot van der, DJ Araten, DS Holt, E Lach-Trifilieff, E Marchiafava, G Gronowicz, GL Logue, GV Seaman, J Nishimura, J Takeda, JD Tamerius, JE May, JP Atkinson, JV Dacie, L Luzzatto, L Luzzatto, L Luzzatto, M Bessler, M Harboe, M Kono, M Loschi, M Sica, M Sica, MA Lindorfer, Maria De Angioletti, MH Holguin, Michela Sica, MJ Harder, MK Pangburn, MK Pangburn, P Hillmen, P Hillmen, P Hillmen, Patrizia Ricci, PJ Lachmann, PJ Lachmann, RJ Kelly, RL Sparrow, Rosario Notaro, RP Latour de, RP Rother, S Berentsen, SK Krishnan, T Olutogun, T Rondelli, TH Ham, Tommaso Rondelli, UM Reiss, VM Holers, VP Ferreira, WF Rosse, WF Rosse, Z Fishelson, Z Lin   +64 more
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Functional and antigenic properties of complement receptor type 2, CR2

Journal of Experimental Medicine, 1987
This is the first report demonstrating that C3d receptor (CR2) has functional activity in regulating complement cascade. Purified CR2 was examined for its cofactor activity in factor I-mediated cleavage of membrane-bound iC3b. CR2 plus C3b inactivator (I)
Katsuyuki Mitomo, T. Fujita, Kyoko 1 Ida
semanticscholar   +1 more source

Solubilization of immune precipitates by six isolated alternative pathway proteins

Journal of Experimental Medicine, 1981
Immune precipitates were solubilized by the alternative pathway of complement assembled from isolated proteins, i.e., C3, factor B, factor D, properdin, C3b inactivator (C3bINA), and beta 1H.
Fujita Teizo, Takata Yuko, Tamura Noboru
semanticscholar   +1 more source

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity [PDF]

, 2009
38 p.- 7 fig.Mutations and polymorphisms in the gene encoding factor H (CFH) have been associated with atypical haemolytic uraemic syndrome, dense deposit disease and age-related macular degeneration.
de Cordoba, Santiago Rodriguez, Harris, Claire Louise, Martinez-Barricarte, Ruben, Montes, Tamara, Morgan, Bryan Paul, Tortajada, Agustin   +5 more
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Downsizing a human inflammatory protein to a small molecule with equal potency and functionality [PDF]

, 2013
A significant challenge in chemistry is to rationally reproduce the functional potency of a protein in a small molecule, which is cheaper to manufacture, non-immunogenic, and also both stable and bioavailable.
A Ghassemian, A Jacob, A Sonesson, AS Kirshenbaum, BL Wu, BN Bullock, CC Scully, D Seebach, DP Fairlie, EB Grant, F Denonne, F Denonne, G Bajic, G Ruiz-Gomez, H Takematsu, H Yin, H-C Wilken, J Kildsgaard, J Lim, J Venkatraman, JA Ember, JDA Tyndall, JM Scholtz, JZ Sun, KD Stigers, L Dreier, LM Proctor, M Pasupuleti, MN Munkonda, N Mizutani, NP Gerard, P Hutamekalin, P-J Haas, PF Zipfel, R Huber, RS Ames, SL Masters, TE Hugli, TE Hugli, TH Chao, VA Bokisch, WF DeGrado, Y Fukuoka, Y Mamane, Z Tang   +44 more
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Complement Split Product C5a Mediates the Lipopolysaccharide‐Induced Mobilization of Cfu‐S and Haemopoietic Progenitor Cells, But Not the Mobilization Induced By Proteolytic Enzymes [PDF]

, 1986
. Intravenous (i.v.) injection of mice with lipopolysaccharide (LPS), and the proteolytic enzymes trypsin and proteinase, mobilizes pluripotent haemopoietic stem cells (CFU‐s) as well as granulocyte‐macrophage progenitor cells (GM‐CFU) and the early ...
Benner R., Bertoncello I., Cline M.J., Daha M.R., Daha M.R., Daha M.R., Daha M.R., Fernandez H.N., Goodman J.W., Ham A.C., Hara M., Hugli T.E., Kessel K.P.M., Loor F., Molenaar J.L., Molendijk W.J., Perez H.D., Ploemacher R.E., Rickard K.A., Rosen F.S., Ross W.M., Snyderman R., Snyderman R., Vos O., Vos O., Wilschut I.J.C.   +25 more
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Elastase-alpha1-proteinase inhibitor complex [PDF]

, 1984
Bergmeyer, H. U., Bergmeyer, J., Graßl, M., Jochum, Marianne, Neumann, S.   +4 more
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The pathophysiology of the complement system in leprosy [PDF]

, 1991
The complement system, which consists of a group of proteins and glycoproteins, generally serves to amplify the effects of the interaction of antigen with antibody.
Ramanathan, V D
core  

Pathobiochemistry of Sepsis [PDF]

, 1986
Duswald, Karl-Heimo, Fritz, Hans, Inthorn, D., Jochum, Marianne, Welter, H. F., Witte, J.   +5 more
core   +1 more source

Complement system and alcoholic liver disease [PDF]

, 2008
Alcoholic liver disease (ALD) is a well recognized and growing health problem worldwide. ALD advances from fatty liver to inflammation, necrosis, fibrosis and cirrhosis.
Bykov, Igor
core