Results 101 to 110 of about 1,596,091 (292)

Modulator-induced conformational changes in complement C5, implications for function and drug design

Frontiers in Immunology
BackgroundThe human complement system comprises proteolytic cascades that drive protective inflammatory and cytolytic responses, making it a crucial part of innate immunity.
Andrey Zhivnov, Carolina Ottochian, Karim El-Bouri, Rose Francis, Rosie Campbell, Alex Macpherson, Stephen Wells, Jean MH van den Elsen   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP) [PDF]

, 2007
Includes bibliographical references (leaves 96-114).Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement
Paulsen, Janis
core   +1 more source

Complement C5 inhibitor as a rescue therapy for acute NMOSD attacks: a multicenter retrospective cohort study in China

Frontiers in Immunology
BackgroundComplement activation plays a key role in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). While eculizumab effectively prevents relapses, its role in acute attacks remains uncertain.MethodsWe retrospectively analyzed 38 ...
Tao Wu, Decai Tian, Dehui Huang, Lei Wu, Jin Zhen, Jian Yin, Jia Guo, Jingli Jiang, Fan Li, Haiqiang Jin, Yiming Zheng, Zhaoxia Wang, Ran Liu, Feng Gao   +13 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Different IVIG glycoforms affect in vitro inhibition of anti-ganglioside antibody-mediated complement deposition [PDF]

, 2014
Intravenous immunoglobulin (IVIG) is the first line treatment for Guillain–Barré syndrome and multifocal motor neuropathy, which are caused by anti-ganglioside antibody-mediated complement-dependent cytotoxicity.
Yamaguchi, Yoshiki, Yuki, Nobuhiro, Peter J Späth, Shahrizaila, Nortina, Nortina Shahrizaila (635406), Makoto Sudo (635402), Peter J. Späth (635403), Benjamin K. Ong (635405), Yoshiki Yamaguchi, Yoshiki Yamaguchi (132437), Kana Matsumoto-Morita (635404), Sudo, Makoto, Benjamin K Ong, Nobuhiro Yuki (60770), Nortina Shahrizaila, Peter J. Späth, Matsumoto-Morita, Kana, Späth, Peter Julius, Makoto Sudo, Ong, Benjamin K., Benjamin K. Ong, Nobuhiro Yuki, Kana Matsumoto-Morita   +22 more
core   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Aliskiren and the dual complement inhibition concept

Clinical Kidney Journal, 2019
Abstract In this issue of Clinical Kidney Journal, Plasse et al. report on the use of high-dose aliskiren as an adjunct therapy in a patient treated with eculizumab for haemolytic uraemic syndrome (HUS). This follows the recent description of the complement factor 3 (C3) activating activity of the enzyme renin and the successful ...
Perez-Gomez, Maria Vanessa, Ortiz, Alberto   +1 more
openaire   +2 more sources

Structural basis for complement factor H-linked age-related macular degeneration [PDF]

, 2007
Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His ...
Pietro Roversi, Clark, S, Robert B. Sim, Susan M. Lea, Jowitt, Thomas A., Beverly E. Prosser, Prosser, Beverly E., Prosser, B, Day, Anthony J., Herbert, AP, Dušan Uhrín, Sim, Robert B., Uhrin, Dusan, Barlow, P, Johnson, S, Lea, SM, Steven Johnson, Blaum, Barbel S., Barlow, Paul N., Herbert, A, Barlow, PN, Sim, RB, Simon J. Clark, Roversi, P, Uhrín, D, Johnson, Steven, Thomas A. Jowitt, Day, A, Jowitt, Thomas A.; id_orcid, Edward Tarelli, Jess Tyrrell, Lea, Susan M., Tyrrell, J, Blaum, BS, Herbert, Andrew P., Clark, Simon J., Tyrrell, Jess, Day, Anthony J.; id_orcid, Lea, Susan, Tarelli, E, Clark, SJ, Paul N. Barlow, Bärbel S. Blaum, Clark, Simon; id_orcid, Tarelli, Edward, Prosser, BE, Jowitt, TA, Day, AJ, Andrew P. Herbert, Roversi, Pietro, Anthony J. Day   +50 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source