Results 81 to 90 of about 1,596,091 (292)

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]

, 2010
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Peter F. Zipfel, Dam, A.P. van, Schuijt, Tim J., Kraiczy, Peter, Nathalie D. van Burgel, Nathalie D. van Burgel, van Dam, Alje P., van Burgel Nathalie D, Burgel, N.D. van, Burgel, Nathalie D. van, Schuijt Tim J, Tim J. Schuijt, Kraiczy Peter, Schuijt, T.J., van Dam Alje P, Zipfel Peter F, Kraiczy, P., Zipfel, Peter F., Alje P. van Dam, Peter Kraiczy, Zipfel, P.F., Dam, Alje P. van, van Burgel, Nathalie D.   +22 more
core   +1 more source

Complement-TAAD

, 2023
TAAD and ...
Chunmei Piao (17557050)
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]

, 1993
Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Siebeck, Matthias, Shimamoto, Kazuaki, Weipert, Joachim, Kroworsch, Peter, Spannagl, Michael, Schweiberer, Leonhard, Jochum, Marianne, Fritz, Hans, Fink, Edwin   +8 more
core   +1 more source

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Combination therapy of sutimlimab and rituximab can lead to stable remission in autoimmune hemolytic anemia: a case series

Annals of Hematology
Autoimmune hemolytic anemia (AIHA) is associated with a significant impairment of quality of life for affected patients and can lead to life-threating hemolytic crises.
Julian List, Anna Katharina Foerster, Alexandra Kutilina, Justus Duyster, Jesus Duque-Afonso, Reinhard Marks   +5 more
doaj   +1 more source

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

Frontiers in Immunology, 2018
The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz, Rafael Bayarri-Olmos, Nikolaj Kirketerp-Møller, Sander van Putten, Katrine Pilely, Mikkel-Ole Skjoedt, Peter Garred   +6 more
doaj   +1 more source