Results 71 to 80 of about 1,688,140 (295)
Complement activation and protein adsorption by carbon nanotubes [PDF]
, 2006 As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel +6 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Role of Complement in Tumors
, 2020 The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis.
core +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational NeurologyObjective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG)
Lea Gerischer +14 more
doaj +1 more source
Inhibition of Complement by Heterologous Hemoglobin
Experimental Biology and Medicine, 1962 Summary and conclusionsMeasurements of relative hemolytic activity of varying mixtures of complement, red cells, and hemolysin with added heterologous protein reveal inhibition or apparent partial complement fixation in the absence of known previous immunization. The added protein in these studies is either hemoglobin or human gamma globulin.
openaire +2 more sources
The role of complement inhibition in kidney transplantation [PDF]
British Medical Bulletin, 2017 The complement system which belongs to the innate immune system acts both as a first line of defence against various pathogens and as a guardian of host homeostasis. The role of complement has been recently highlighted in several aspects of kidney transplantation: ischaemia-reperfusion, antibody-mediated rejection and native kidney disease recurrence ...
C, Legendre +3 more
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Inhibition of complement activation in cardiac surgery [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2006 DOI:€10.1016/j.jtcvs.2005.10.019 J Thorac Cardiovasc Surg 2006;131:266-267 Frank W. Sellke and Munir Boodhwani Inhibition of complement activation in cardiac surgery http://jtcs.ctsnetjournals.org/cgi/content/full/131/2/266 located on the World Wide Web at: The online version of this article, along with updated information and services ...
Sellke, Frank W., Boodhwani, Munir
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source