Results 71 to 80 of about 1,596,091 (292)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology
Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG)
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
doaj   +1 more source

The Role of Complement in Tumors

, 2020
The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis.

core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Inhibition of Complement by Heterologous Hemoglobin

Experimental Biology and Medicine, 1962
Summary and conclusionsMeasurements of relative hemolytic activity of varying mixtures of complement, red cells, and hemolysin with added heterologous protein reveal inhibition or apparent partial complement fixation in the absence of known previous immunization. The added protein in these studies is either hemoglobin or human gamma globulin.
openaire   +2 more sources

The role of complement inhibition in kidney transplantation [PDF]

British Medical Bulletin, 2017
The complement system which belongs to the innate immune system acts both as a first line of defence against various pathogens and as a guardian of host homeostasis. The role of complement has been recently highlighted in several aspects of kidney transplantation: ischaemia-reperfusion, antibody-mediated rejection and native kidney disease recurrence ...
C, Legendre, R, Sberro-Soussan, J, Zuber, V, Frémeaux-Bacchi   +3 more
openaire   +2 more sources

Advancing therapeutic complement inhibition in hematologic diseases: PNH and beyond

, 2022
: Complement is an elaborate system of innate immunity. Genetic variants and autoantibodies leading to excessive complement activation are implicated in a variety of human diseases. Among them, the hematologic disease paroxysmal nocturnal hemoglobinuria (
Gavriilaki, Eleni, de Latour, Régis Peffault, Risitano, Antonio Maria   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Targeting the Roots of Kidney Disease: Systematic Review of the Therapies Targeting the Complement System

Medicina
Background/Objectives: The field of nephrology is increasingly embracing advanced treatments and clinical trials that focus on inhibiting specific components of the complement cascade, a key driver in complement-mediated kidney diseases.
Maja Roman, Michał Nowicki
doaj   +1 more source

Inhibition of complement activation in cardiac surgery [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2006
DOI:€10.1016/j.jtcvs.2005.10.019 J Thorac Cardiovasc Surg 2006;131:266-267 Frank W. Sellke and Munir Boodhwani Inhibition of complement activation in cardiac surgery http://jtcs.ctsnetjournals.org/cgi/content/full/131/2/266 located on the World Wide Web at: The online version of this article, along with updated information and services ...
Sellke, Frank W., Boodhwani, Munir
openaire   +2 more sources