Results 161 to 170 of about 1,688,140 (295)

Complement Inhibition in Geographic Atrophy: Clinical Evidence for Pegcetacoplan and Avacincaptad Pegol. [PDF]

Cureus
Orozco Loaiza G, Alfaro Guerra MJ, Murillo Sotela A, Villalobos Villalobos P.   +3 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Anti-C2-mediated complement inhibition prevents disease in a rat passive transfer model of myasthenia gravis. [PDF]

J Transl Autoimmun
Arets B, Peng S, Bracke L, De Winter K, Delaere J, Driege Y, Delahaye T, Moshir M, Van de Walle I, Ulrichts P, Mané-Damas M, Losen M, Martinez-Martinez P.   +12 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

A decade of complement inhibition in post-transplant atypical HUS: outcomes with eculizumab and ravulizumab. [PDF]

Clin Kidney J
Gopireddy NSR, Kumar A, Smith RJH, Nester CM, Thomas CP.   +4 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Complement inhibition by a unique cluster of immunomodulatory outer surface proteins of Borrelia recurrentis. [PDF]

Nat Commun
Röttgerding F, Reyer F, Gerlach E, Amborn M, Duschek N, Schultze TG, Fingerle V, Roome CM, Stumpf M, Becker K, Rahlfs S, Przyborski JM, Kraiczy P, Fritz-Wolf K.   +13 more
europepmc   +1 more source

Challenges in IgA Nephropathy Management: An Era of Complement Inhibition. [PDF]

Kidney Int Rep, 2023
Tesař V, Radhakrishnan J, Charu V, Barratt J.   +3 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Complement inhibition by sutimlimab in cold agglutinin disease promotes red blood cell agglutination and may lead to circulatory complications, eryptosis and hemolysis. [PDF]

Front Immunol
Bartolmäs T, Mayer B, Salama A.
europepmc   +1 more source