Results 81 to 90 of about 80,513 (156)

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention

Frontiers in Immunology, 2019
The interactions of cancer cells with components of the complement system are highly complex, leading to an outcome that is either favorable or detrimental to cancer cells. Currently, we perceive only the “tip of the iceberg” of these interactions.
Zvi Fishelson, Michael Kirschfink
doaj   +1 more source

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]

, 2015
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC, Gjertson, D, Mulder, A, Panicker, S, Parry, GC, Reed, EF, Thomas, KA, Valenzuela, NM   +7 more
core   +1 more source

Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution

, 2019
The surface of proteins is heterogeneous with sophisticated but precise hydrophobic and hydrophilic patches, which is essential for their diverse biological functions.
Andreozzi, P., Chakrabortty, S., D’Alicarnasso, M., Frank, L., Hammer, B., Kreppel, F., Krol, S., Kuan, S., Landfester, K., Li, L., Liu, W., Müllen, K., Pelliccia, M., Simon, J., Stellacci, F., Wagner, J., Weil, T., Wu, Y.   +17 more
core   +1 more source

Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia

Platelets, 2017
In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger, Beate Eichelberger, Anja Ulz, Simon Panzer   +3 more
doaj   +1 more source

Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets. [PDF]

Am J Pathol, 2020
Xie CB, Jane-Wit D, Pober JS.
europepmc   +1 more source

Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization

Scientific Reports
The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part of our innate immune response that can
Frerich M. Masson, Salvör Káradóttir, Sjors P. A. van der Lans, Dennis J. Doorduijn, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Bart W. Bardoel   +6 more
doaj   +1 more source

The Immune System [PDF]

, 1995
Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being ...
Gallucci, Betty Bierut, McCarthy, Donna O.   +1 more
core   +1 more source

PRELP protein inhibits the formation of the complement membrane attack complex. [PDF]

J Biol Chem, 2012
Happonen KE, Fürst CM, Saxne T, Heinegård D, Blom AM.   +4 more
europepmc   +2 more sources

Sarcolemmal Complement Membrane Attack Complex Deposits During Acute Rejection of Myofibers in Nonhuman Primates. [PDF]

J Neuropathol Exp Neurol, 2019
Skuk D, Tremblay JP.
europepmc   +1 more source

Membrane attack complex in biliary atresia: new insight for etiopathogenesis

Egyptian Liver Journal
Purpose Biliary atresia (BA) is the most common cause of neonatal cholestasis (NC); nevertheless, there is a lack of an established etiology. Understanding etiopathogenesis opens the way to adjuvant medical therapy.
Mohamed Abdel-Salam El-Guindi, Nermin Mohamed Adawy, Riham Rabie Issa, Shereen Mohammed El-Mashad, Ahmad Mohamed Sira, Gihan Ahmed Sobhy   +5 more
doaj   +1 more source