Results 61 to 70 of about 471,706 (342)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig- to-rat xenotransplantation [PDF]

, 1995
In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well ...
Adachi, Anthony J. Demetris, Cochrane, Gewurz, Hasan, Hideaki Miyazawa, Hong, Iida, Kissmeyer-Nielsen, Kitano, Kitano, Leventhal, Minoru Nomoto, Mitsuko Tanaka, Miyagawa, Miyagawa, Miyazaki, Miyazaki, Miyazawa, Murase, Nelson, Noriko Murase, Ono, Perper, Pruitt, Pruitt, Qing Ye, Rafael Manez, Satoru Todo, Soares, Starzl, Starzl, Starzl, Starzl, Tanaka, Thomas E. Starzl, Valdivia, Van den Bogaerde, Wasei Miyazaki, Xia, Yamamoto, Yoichi Toyama   +41 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Autoantibodies against alternative complement pathway proteins in renal pathologies

Nefrología (English Edition), 2016
Complement system activation plays an important role in several renal pathologies, including antibody-mediated glomerulonephritis, ischaemia–reperfusion injury of transplanted kidneys or renal allograft rejection.
Pilar Nozal, Margarita López-Trascasa
doaj   +1 more source

Activation of the alternative complement pathway by Naegleria fowleri [PDF]

Infection and Immunity, 1980
Naegleria fowleri amoebae were lysed by adult fresh human serum, and their multiplication was inhibited in culture medium supplemented with 10% fresh human serum. Heat inactivation (56 degrees C, 30 min) of serum abrogated these lytic and inhibitory effects.
T W Holbrook, R J Boackle, Brenda W. Parker, Jana Vesely   +3 more
openaire   +3 more sources

Neutrophils from ANCA-associated vasculitis patients show an increased capacity to activate the complement system via the alternative pathway after ANCA stimulation.

PLoS ONE, 2019
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), are autoimmune conditions associated with small vessel inflammation.
Sophie Ohlsson, Lisa Holm, Christina Hansson, Susanne M Ohlsson, Lena Gunnarsson, Åsa Pettersson, Lillemor Skattum   +6 more
doaj   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Activation of the Alternative Complement Pathway by Fonsecaea pedrosoi

Journal of Investigative Dermatology, 1984
Human sera were examined for evidence of complement activation by Fonsecaea pedrosoi. The serum that had been incubated with F. pedrosoi showed immunoelectrophoretic C3 conversion and generation of C5a, as measured by radioimmunoassay. C3 conversion and C5a generation did not occur in serum chelated with EDTA, or in serum heated to 56 degrees C for 30 ...
Hachiro Tagami, Kyoko Okohchi, H. Takematsu, Wakio Torinuki   +3 more
openaire   +3 more sources

Complotype affects the extent of down-regulation by Factor I of the C3b feedback cycle in vitro. [PDF]

, 2014
Sera from a large panel of normal subjects were typed for three common polymorphisms, one in C3 (R102G) and two in Factor H (V62I and Y402H), that influence predisposition to age-related macular degeneration and to some forms of kidney disease.
Buchberger, A, Hiles, I, Lachmann, PJ, Lay, E, Nutland, S, Schwaeble, W, Seilly, DJ, Smith, JE, Smith, RAG   +8 more
core   +1 more source