Results 61 to 70 of about 425,149 (322)

Dispensability of Escherichia coli's latent pathways [PDF]

Proc. Natl. Acad. Sci. USA 108, 3124-3129 (2011), 2011
Gene-knockout experiments on single-cell organisms have established that expression of a substantial fraction of genes is not needed for optimal growth. This problem acquired a new dimension with the recent discovery that environmental and genetic perturbations of the bacterium Escherichia coli are followed by the temporary activation of a large number
arxiv   +1 more source

Activation of the alternative complement pathway by Histoplasma capsulatum [PDF]

Infection and Immunity, 1980
The present study was performed to determine whether Histoplasma capsulatum (yeast phase) is able to activate the alternative complement pathway. H. capsulatum yeasts were shown to consume C3 in C4-deficient guinea pig serum. Immunoelectrophoretic conversion of alternative pathway component factor B confirmed that C3 consumption was mediated by ...
J M Pepple, J A Winkelstein, W D Ratnoff
openaire   +3 more sources

Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System [PDF]

, 2017
Von Willebrand factor (VWF), a multimeric protein that has a central role in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive.
Bettoni, Serena
core   +1 more source

Complement factors B, D, C3bBbP and risk of future venous thromboembolism [PDF]

, 2023
The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured at inclusion, with the risk of ...
Brækkan, Sigrid Kufaas, Evensen, Line Holtet, Hansen, John Bjarne, Hindberg, Kristian Dalsbø, Jensen, Søren Beck, Latysheva, Nadezhda, Michelsen, Annika Elisabet, Mollnes, Tom Eirik, Skjeflo, Espen Waage, Snir, Omri, Ueland, Thor   +10 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

C3 glomerulopathy and current dilemmas [PDF]

, 2017
C3 glomerulopathy (C3G) is a recently identified disease entity caused by dysregulation of the alternative complement pathway, and dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are its components. Because laboratory detection of complement
Ito Naoko, Nagata Michio, Ohashi Ryuji, 長田 道夫   +3 more
core   +2 more sources

Successful pharmacological intervention at different levels of the complement system in an in vitro complement fixation model for bullous pemphigoid [PDF]

, 2023
Bullous pemphigoid (BP) is characterized by deposition of immunoglobulins and complement along the epidermal basement membrane (BM). In humans, there is a lack of functional studies targeting the complement system (CS). This study investigates activation
Damman, Jeffrey, de Cordoba, Santiago Rodriguez, Diercks, Gilles F.H., Giang, Jenny, Poppelaars, Felix, Schreurs, Marco W.J., van den Bosch, Thierry P.P., van Doorn, Martijn B.A.   +7 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Neutrophils from ANCA-associated vasculitis patients show an increased capacity to activate the complement system via the alternative pathway after ANCA stimulation.

PLoS ONE, 2019
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), are autoimmune conditions associated with small vessel inflammation.
Sophie Ohlsson, Lisa Holm, Christina Hansson, Susanne M Ohlsson, Lena Gunnarsson, Åsa Pettersson, Lillemor Skattum   +6 more
doaj   +1 more source

Essential twisted surfaces in alternating link complements [PDF]

Algebr. Geom. Topol. 16 (2016) 3209-3270, 2014
Checkerboard surfaces in alternating link complements are used frequently to determine information about the link. However, when many crossings are added to a single twist region of a link diagram, the geometry of the link complement stabilizes (approaches a geometric limit), but a corresponding checkerboard surface increases in complexity with ...
arxiv   +1 more source