Results 81 to 90 of about 425,149 (322)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Autoantibodies against alternative complement pathway proteins in renal pathologies

Nefrología (English Edition), 2016
Complement system activation plays an important role in several renal pathologies, including antibody-mediated glomerulonephritis, ischaemia–reperfusion injury of transplanted kidneys or renal allograft rejection.
Pilar Nozal, Margarita López-Trascasa
doaj   +1 more source

Complement-Amplifying Conditions in Atypical Hemolytic Uremic Syndrome: A Canadian Case Series

Canadian Journal of Kidney Health and Disease, 2022
Rationale: Thrombotic microangiopathies (TMAs) are systemic disorders that often affect the kidneys and encompass a heterogeneous group of conditions, including atypical hemolytic uremic syndrome (aHUS).
Christopher J. Patriquin, Katerina Pavenski, Jocelyn Garland, Louis-Philippe Girard, Paul Isenring   +4 more
doaj   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19 [PDF]

, 2022
Complement, a critical defence against pathogens, has been implicated as a driver of pathology in COVID-19. Complement activation products are detected in plasma and tissues and complement blockade considered for therapy. To delineate roles of complement
Ahmed, KA, Alex, B, Armstrong, JA, Ashworth, M, Asiimwe, IG, Bach, B, Baillie, JK, Baillie, JK, Bakshi, S, Barclay, WS, Barlow, SL, Bogaert, D, Carson, G, Chand, M, Clohisey, S, Connor, M, Cooke, GS, da Silva Filipe, A, Dalton, J, Davies, K, de Silva, T, Docherty, AB, Donohue, C, Drake, TM, Dunning, J, Fairfield, CJ, Fellows, R, Fletcher, T, Gamble, C, Girvan, M, Green, CA, Greenhalf, W, Griffiths, F, Gupta, RK, Halpin, S, Hardwick, H, Harris, CL, Harrison, EM, Harrison, J, Hendry, R, Hiscox, JA, Ho, AYW, Horby, PW, Ijaz, S, Jackson, C, Keating, S, Khoo, S, Klenerman, P, Knight, SR, Law, A, Law, A, Leeming, G, Lim, WS, Lyons, R, Marsh, L, McDonald, S, Mclean, KA, Mentzer, AJ, Merson, L, Meynert, AM, Moore, SC, Morgan, BP, Murphy, D, Norman, L, Noursadeghi, M, Oosthuyzen, W, Openshaw, PJM, Openshaw, PJM, Palmarini, M, Paxton, WA, Pius, R, Pollakis, G, Price, N, Rambaut, A, Roberts, S, Robertson, DL, Russell, CD, Sancho-Shimizu, V, Saviciute, E, Scott, JT, Scott-Brown, J, Semple, MG, Semple, MG, Shaw, CA, Shaw, V, Sigfrid, L, Siggins, MK, Solomon, T, Sriskandan, S, Stuart, D, Summers, C, Tedder, RS, Thompson, AAR, Thomson, EC, Thwaites, RS, Thwaites, RS, Turtle, LCW, Wham, M, Zambon, M, Zelek, WM   +99 more
core  

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi [PDF]

, 2017
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis.
A Bhattacharjee, A Richards, Adrian Goldman, AJ McCoy, AO Edwards, B Nagar, BS Blaum, C Hammerschmidt, C Siegel, CA Diebolder, Catherine A. Brissette, D Weismann, DE Isenman, DL Gordon, E Goicoechea de Jorge, E Krissinel, EM Adams, J Esparza-Gordillo, J Hellwage, J Pietikäinen, J Wu, JD Lambris, JH Williams Jr., JJ Caesar, JJ Caesar, JM van den Elsen, JM Weiler, K Brangulis, K Haupt, K Whaley, Kornelia M. Mikula, M Jozsi, M Jozsi, M Jozsi, MC Carroll, MD Winn, MJ Lehtinen, MJ Lehtinen, MJ Walport, MK Pangburn, P Emsley, P Kraiczy, PD Adams, PF Zipfel, PW Dempsey, RB Sim, Robert Kolodziejczyk, S Breitner-Ruddock, S Hyvärinen, S Kühn, S Ram, T Kajander, T Meri, T. Sakari Jokiranta, Taru Meri, Tommi Kotila, TS Jokiranta, Vincent L. G. Postis, W Kabsch   +58 more
core   +3 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Components of the alternative complement pathway in patients with psoriasis

Acta Dermatovenerologica Alpina Pannonica et Adriatica, 2017
Psoriasis is a chronic inflammatory skin disease. Adipose tissue plays important roles in the events that regulate body metabolism. This study determined the levels of complement 3 ( C3), acylation-stimulating protein (ASP), and adipsin, which take part in the alternate complement pathway, and are synthesized in and secreted by adipose tissue.Thirty ...
Şereflican, Betül, Buğdaycı, Güler
openaire   +4 more sources

Alternative Pathway of Complement in Sickle Cell Disease [PDF]

Pediatric Research, 1977
Thirty-one patients, 10 months to 20 years of age, were studied. A complement abnormality was not identified in sera from patients with sickle cell disease (SCD) by the methods employed in the present study. Concentrations of C3, factor B, total hemolytic activity (CH50), properdin, and C3b inactivator were similar in sera from patients and control ...
Clark D. West, Theresa Asbrock, Judith Forristal, Ronald G. Strauss   +3 more
openaire   +2 more sources