Results 21 to 30 of about 247,050 (333)

Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots [PDF]

Frontiers in Immunology
The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang, Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Uday Kishore, Robert B. Sim   +7 more
doaj   +4 more sources

Inhibition of the Classical Pathway of Complement by Meningococcal Capsular Polysaccharides [PDF]

The Journal of Immunology, 2014
Abstract Almost all invasive Neisseria meningitidis isolates express capsular polysaccharide. Ab is required for complement-dependent killing of meningococci. Although alternative pathway evasion has received considerable attention, little is known about classical pathway (CP) inhibition by meningococci, which forms the basis of this ...
S. Agarwal, Shreekant Vasudhev, R. DeOliveira, S. Ram   +3 more
semanticscholar   +3 more sources

Deficient Classical Complement Pathway Activity in Newborn Sera [PDF]

Pediatric Research, 1983
Summary: The bactericidal activity of 20 maternal-neonatal paired sera was assessed employing a clinical type la, group B streptococcal isolate, strain 515, known to be opsonized by the classical complement pathway in a non-antibody dependent fashion.
M. Edwards, G. Buffone, P. A. Fuselier, J. Weeks, C. Baker   +4 more
semanticscholar   +4 more sources

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Molecular Neurodegeneration, 2018
Background The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD).
Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli   +7 more
doaj   +2 more sources

Editorial: Community series in the role of complement in health and disease, volume II [PDF]

Frontiers in Immunology
Maciej Cedzyński, Thomas Vorup-Jensen, Thomas Vorup-Jensen, Marcin Okrój, Anna S. Świerzko   +4 more
doaj   +2 more sources

Classical Complement Pathway Inhibition in a “Human‐On‐A‐Chip” Model of Autoimmune Demyelinating Neuropathies

Advances in Therapy, 2022
Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here the authors describe a phenotypic, human‐on‐a‐chip (HoaC) electrical conduction model of two rare autoimmune ...
J. Rumsey, Case Lorance, Max Jackson, Trevor Sasserath, C. McAleer, C. Long, A. Goswami, M. Russo, S. Raja, K. Gable, Doug Emmett, L. Hobson‐Webb, M. Chopra, J. Howard, J. Guptill, M. Storek, M. Alonso-Alonso, N. Atassi, S. Panicker, G. Parry, Timothy R. Hammond, J. Hickman   +21 more
semanticscholar   +1 more source

Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia

Blood Advances, 2022
Key Points • Classical complement pathway activation contributes to the pathophysiology and clinical heterogeneity of immune thrombocytopenia (ITP).• Sutimlimab rapidly and durably increased platelet count in patients with chronic ITP by selectively ...
C. Broome, A. Röth, D. Kuter, M. Scully, Roy E. Smith, Jennifer P. Wang, C. Reuter, W. Hobbs, A. Daak   +8 more
semanticscholar   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery

Molecules, 2020
The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases.
Blake R. Rushing, Denise L. Rohlik, Sourav Roy, D. Andrew Skaff, Brandon L. Garcia   +4 more
doaj   +1 more source

Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis

Renal Failure, 2022
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima, Dan Inoue, Takeaki Wajima, Takahiro Uchida, Muneharu Yamada, Isao Ohsawa, Takashi Oda   +6 more
doaj   +1 more source