Results 91 to 100 of about 11,460 (178)

Classical and mannose-binding-lectin complement pathway activation in patients with ANCA associated vasculitis

Clinical Kidney Journal
Abstract Introduction While the complement system's role in ANCA-associated vasculitis (AAV) pathogenesis is well-established, the interplay between its activation pathways remains enigmatic. Specifically, evidence regarding the classical and mannose-binding lectin (MBL) pathways is inconsistent ...
Florian G Scurt, Verena Hirschfeld, Maximilian J Ganz, Carolin Herzog, Peter R Mertens, Christos Chatzikyrkou   +5 more
openaire   +1 more source

Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?

mBio, 2012
Dengue viruses (DENV) cause a spectrum of disease in humans, ranging from dengue fever (DF) to a severe, life-threatening syndrome called dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Despite the global morbidity and mortality associated with
Sujan Shresta
doaj   +1 more source

A Novel Fluorochrome Linked Immunosorbent Assay (FLISA) for the complete analysis of the mannose binding lectin (MBL) complement pathway.

The FASEB Journal, 2007
In addition to recognizing pathogen‐associated molecular patterns, early components of the MBL‐dependent lectin complement pathway (LCP) also recognize self‐antigens and/or IgM following oxidative stress. Current assays for MBL lack the ability to assess all components of the LCP in a single assay system. In the present study, we developed a novel, low
Mary Christine Walsh, Lisa A Shaffer, Simon C Body, Stanton K Shernan, Amanda A Fox, Charles D Collard, Ronald P Taylor, Gregory L Stahl   +7 more
openaire   +1 more source

Complement in the Initiation and Evolution of Rheumatoid Arthritis

Frontiers in Immunology, 2018
The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and ...
V. Michael Holers, Nirmal K. Banda
doaj   +1 more source

Association Study of Mannose-Binding Lectin Levels and Genetic Variants in Lectin Pathway Proteins with Susceptibility to Age-Related Macular Degeneration: A Case-Control Study.

PLoS ONE, 2015
BackgroundIn age-related macular degeneration (AMD) the complement system is thought to be activated by chronic oxidative damage with genetic variants identified in the alternative pathway as susceptibility factors. However, the involvement of the lectin
Michael Osthoff, Melinda M Dean, Paul N Baird, Andrea J Richardson, Mark Daniell, Robyn H Guymer, Damon P Eisen   +6 more
doaj   +1 more source

Activation of the lectin complement pathway on human renal glomerular endothelial cells triggered by high glucose and mannose-binding lectin

AFRICAN JOURNAL OF BIOTECHNOLOGY, 2011
This study aimed to investigate the roles of high glucose and mannose-binding lectin (MBL) on the activation of the lectin complement pathway (LCP) on human renal glomerular endothelial cells (HRGECs) in vitro . Flow cytometry analysis, immunofluorescence staining and Western blot were used to detect the cell surface deposition of MBL, C3 and the ...
openaire   +1 more source

Mannose-binding lectin may affect pregnancy outcome

The Turkish Journal of Pediatrics, 2015
Mannose-binding lectin (MBL) is a component of the innate immune system and acts as a complement activator through the lectin pathway. Genetic variations of MBL and low MBL levels cause several infection problems, which may also be related to ...
Şebnem Çalkavur, Fuat Akercan, Ferda Özkınay, Güzide Aksu, Osman Zekioğlu, Mehmet Yalaz, Özge Altun Köroğlu, Hüseyin Onay, Gülin Erdemir, Nilgün Kültürsay   +9 more
doaj  

Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity. [PDF]

Lupus Sci Med
Lindelöf L, Garred P, Hong MG, Wahl Vælum S, Holten Petersen L, Leonard D, Sayadi A, Oke V, Niewold TB, Diaz-Gallo LM, Saevarsdottir S, Gunnarsson I, Svenungsson E, Eriksson O.   +13 more
europepmc   +1 more source

Glycan-encoded immune checkpoints and allorecognition: a mechanistic framework for transplantation and organ engineering. [PDF]

Front Transplant
Rana MM, Withers SG, Choy JC, Kizhakkedathu JN.   +3 more
europepmc   +1 more source

C3 glomerulopathy in transplant "like yet unlike native": Pathophysiology, recent advances in therapeutics and evolving paradigms. [PDF]

World J Transplant
Chutani A, Norouzi S, Lerma EV.
europepmc   +1 more source