Results 131 to 140 of about 23,299 (223)

A Novel Fluorochrome Linked Immunosorbent Assay (FLISA) for the complete analysis of the mannose binding lectin (MBL) complement pathway.

The FASEB Journal, 2007
In addition to recognizing pathogen‐associated molecular patterns, early components of the MBL‐dependent lectin complement pathway (LCP) also recognize self‐antigens and/or IgM following oxidative stress. Current assays for MBL lack the ability to assess all components of the LCP in a single assay system. In the present study, we developed a novel, low
Mary Christine Walsh, Lisa A Shaffer, Simon C Body, Stanton K Shernan, Amanda A Fox, Charles D Collard, Ronald P Taylor, Gregory L Stahl   +7 more
openaire   +1 more source

Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal–Fetal Tolerance

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao, Li Zou, Yao Yao, Changling Liu   +3 more
wiley   +1 more source

Complement in the Initiation and Evolution of Rheumatoid Arthritis

Frontiers in Immunology, 2018
The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and ...
V. Michael Holers, Nirmal K. Banda
doaj   +1 more source

Complement in patients receiving maintenance hemodialysis: functional screening and quantitative analysis

BMC Nephrology, 2010
Background The complement system is vital for innate immunity and is implicated in the pathogenesis of inflammatory diseases and the mechanism of host defense. Complement deficiencies occasionally cause life-threatening diseases.
Horikoshi Satoshi, Onda Kisara, Ishii Masaya, Kusaba Gaku, Ohsawa Isao, Inoshita Hiroyuki, Ohi Hiroyuki, Tomino Yasuhiko   +7 more
doaj   +1 more source

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

, 2008
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains controversial. To address the impact of TLR-mediated pathogen recognition and MyD88-dependent signaling events on anti ...
Abel, Bafica, Blander, Branger, Brightbill, Carroll, Cooper, Drennan, Feng, Flynn, Flynn, Fremond, Fremond, Gilleron, Gutierrez, Han, Holscher, Holscher, Hsieh, Jones, Kamath, Kaufmann, Kaufmann, Kawai, Krieg, MacMicking, MacMicking, Maher, Martinon, Means, Means, Means, Medzhitov, North, Quesniaux, Rausch, Reiling, Ryffel, Scanga, Scanga, Schaible, Seki, Shi, Shi, Shim, Sugawara, Sugawara, Sun, Takeuchi, Thoma-Uszynski, Trinchieri, Underhill, van der Wel, Yates   +53 more
core   +1 more source

Classical and mannose-binding-lectin complement pathway activation in patients with ANCA associated vasculitis

Clinical Kidney Journal
Abstract Introduction While the complement system's role in ANCA-associated vasculitis (AAV) pathogenesis is well-established, the interplay between its activation pathways remains enigmatic. Specifically, evidence regarding the classical and mannose-binding lectin (MBL) pathways is inconsistent ...
Florian G Scurt, Verena Hirschfeld, Maximilian J Ganz, Carolin Herzog, Peter R Mertens, Christos Chatzikyrkou   +5 more
openaire   +1 more source

Association Study of Mannose-Binding Lectin Levels and Genetic Variants in Lectin Pathway Proteins with Susceptibility to Age-Related Macular Degeneration: A Case-Control Study.

PLoS ONE, 2015
BackgroundIn age-related macular degeneration (AMD) the complement system is thought to be activated by chronic oxidative damage with genetic variants identified in the alternative pathway as susceptibility factors. However, the involvement of the lectin
Michael Osthoff, Melinda M Dean, Paul N Baird, Andrea J Richardson, Mark Daniell, Robyn H Guymer, Damon P Eisen   +6 more
doaj   +1 more source

La vía de las lectinas en lupus y tuberculosis: polimorfismos de la MBL2 y MASP2, beneficiosos o perjudiciales/ The lectin pathway in lupus and tuberculosis: MBL2 and MASP2 polymorphisms, beneficial or harmful [PDF]

MBL2 exon 1, promoter genotyping and serum MBL concentrations were determined in TB patients (79) and HHC (120) and in SLE cases (39) and controls (59). MASP-2 serum levels and 5 polymorphisms in MASP2 gene were also analyzed in 49 TB patients and 50 HHC
Institut Universitari d'Investigació en Ciències de la Salut, Losada López, Inés   +1 more
core  

Bench-to-bedside review: genetic influences on meningococcal disease [PDF]

, 2002
This review discusses the possible involvement of a variety of genetic polymorphisms on the course of meningococcal disease. It has been shown that several common genetic polymorphisms can either influence the susceptibility to ...
Groot, R. (Ronald) de, Hazelzet, J.A. (Jan), Vermont, C.L. (Clementien)   +2 more
core   +1 more source

Mannose-binding lectin may affect pregnancy outcome

The Turkish Journal of Pediatrics, 2015
Mannose-binding lectin (MBL) is a component of the innate immune system and acts as a complement activator through the lectin pathway. Genetic variations of MBL and low MBL levels cause several infection problems, which may also be related to ...
Şebnem Çalkavur, Fuat Akercan, Ferda Özkınay, Güzide Aksu, Osman Zekioğlu, Mehmet Yalaz, Özge Altun Köroğlu, Hüseyin Onay, Gülin Erdemir, Nilgün Kültürsay   +9 more
doaj