Results 151 to 160 of about 11,460 (178)

Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism [PDF]

Thrombosis Research, 2018
Deep vein thrombosis (DVT) originates in the valvular sinuses of large veins in a local milieu characterized by stasis and severe hypoxia. This may induce complement- and coagulation activation, which potentially increases the risk of venous thromboembolism (VTE).
Ole-Lars Brekke, Tom Mollnes, KRISTIAN Dalsbø Hindberg   +2 more
exaly   +4 more sources

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Mannose-binding lectin complement pathway plays a key role in complement activation by Paracoccidioides brasiliensis

Molecular Immunology, 2009
Paracoccidioides brasiliensis (Pb) is a dimorphic fungal pathogen that causes paracoccidioidomycosis, the most severe deep mycosis from South America. Although cell mediated immunity is considered the most efficient protective mechanism against Pb infection, mechanisms of innate immunity are poorly defined.
Renan G, Toledo, Wilmar D, Da Silva, Vera L G, Calich, Thereza L, Kipnis   +3 more
openaire   +2 more sources

The mannose binding lectin pathway and early complement activation in (murine) abortion

Journal of Reproductive Immunology, 2010
Introduction: Girardi and Salmon highlighted the role of complement in early gestation failures in mice. We wanted to identify the pathway of its early activation in the murine natural immune resorbtion model she used. Methods: We monitored the protein and mRNAs expression of MBL-A and C, C3, at different days of gestation, in the uteri of either an ...
Petitbarat, Marie, Dubanchet, Sylvie, Bulla, Roberta, Sandra, Olivier, Lédée, Nathalie, Tedesco, Francesco, Chaouat, G.   +6 more
openaire   +2 more sources

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: Two genes, five proteins and many functions?

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2012
The lectin pathway of the complement system is activated following the binding of carbohydrate-based ligands by recognition molecules such as mannose-binding lectin (MBL) or ficolins. Engagement of the recognition molecules causes activation of associated MBL-associated serine proteases or MASPs, which in turn activate downstream complement molecules ...
Lakshmi C Wijeyewickrema, Robert Pike
exaly   +3 more sources

Mannose-binding lectin as part of the complement pathway: characterization in non-inflamed and inflamed human eyes

Clinical and Experimental Ophthalmology, 2011
Mark Daniell, Damon Eisen
exaly   +2 more sources

Deposition of mannose‐binding lectin and ficolins and activation of the lectin pathway of complement on the surface of polyurethane tubing used for cardiopulmonary bypass

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2017
AbstractThe artificial surface used for cardiopulmonary bypass (CPB) is a crucial factor activating the complement system and thus contributing to the generation of a systemic inflammatory response. The activation of classical and alternative pathways on this artificial surface is well known.
Łukasz, Eppa, Izabela, Pągowska-Klimek, Anna S, Świerzko, Maciej, Moll, Wojciech R, Krajewski, Maciej, Cedzyński   +5 more
openaire   +2 more sources

Emerging role of the mannose-binding lectin-dependent pathway of complement activation in clinical organ transplantation

Current Opinion in Organ Transplantation, 2011
Over the past decade, the role of the complement system in solid organ transplantation has received increased attention. A number of experimental and epidemiological studies have suggested that the lectin pathway plays a role in infectious complications, rejection and long-term outcome after transplantation.
Berger, S.P., Daha, M.R.
openaire   +3 more sources

A novel measurement method for activation of the lectin complement pathway via both mannose-binding lectin (MBL) and L-ficolin

Journal of Immunological Methods, 2009
Mannose-binding lectin (MBL), L-ficolin and H-ficolin are human serum lectins, all of which form complexes with MBL-associated serine proteases (MASP). The lectin-MASP complexes bind to the surface of microbes, leading to activation of the lectin pathway of complement.
Hiroyuki, Inoshita, Misao, Matsushita, Shunichi, Koide, Gaku, Kusaba, Masaya, Ishii, Kisara, Onda, Min Jin, Gi, Munehiro, Nakata, Isao, Ohsawa, Satoshi, Horikoshi, Hiroyuki, Ohi, Yasuhiko, Tomino   +11 more
openaire   +2 more sources

Analysis of the classical, alternative, and mannose binding lectin pathway of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis

Rheumatology International, 2011
The complement system plays a role in the pathogenesis of some autoimmunopathies. This longitudinal study evaluates the contribution of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis (JIA). Serum of the peripheral blood and the synovial fluid were investigated for the activity of the classical (CP), the ...
Juergen, Brunner, Martina, Prelog, Magdalena, Riedl, Thomas, Giner, Johannes, Hofer, Reinhard, Würzner, Lothar-Bernd, Zimmerhackl   +6 more
openaire   +2 more sources

Mannose-binding lectin as part of the complement pathway: characterization in non-inflamed and inflamed human eyes.

Clinical & experimental ophthalmology, 2012
Mannose-binding lectin plays a central effector role in the lectin pathway of complement activation. Frequently occurring MBL2 polymorphisms result in mannose-binding lectin deficiency, which increases susceptibility to infection. We characterized mannose-binding lectin levels and function in non-inflamed and inflamed human eyes, and evaluated its ...
Chow, Sing-Pey, Dean, Melinda M., Depla, Jozef A., Daniell, Mark D., Eisen, Damon P.   +4 more
openaire   +2 more sources