Results 191 to 200 of about 23,299 (223)
Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency [PDF]
European Journal of Immunology, 2004 AbstractDeficiency of mannose‐binding lectin (MBL), a recognition molecule of the lectin pathway of complement, is associated with increased susceptibility to infections. The high frequency of MBL deficiency suggests that defective MBL‐mediated innate immunity can be compensated by alternative defense strategies.
Anja Roos +2 more
exaly +5 more sources
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Journal of Reproductive Immunology, 2010
Preeclampsia is a severe complication of pregnancy characterized by hypertension and proteinuria developing after midgestation. Previous studies have shown increased complement activation in normal and preeclamptic pregnancies. We aimed to investigate the role of the mannose-binding lectin pathway in the initiation of pathological complement activation
Dorottya Csuka +2 more
exaly +4 more sources
Preeclampsia is a severe complication of pregnancy characterized by hypertension and proteinuria developing after midgestation. Previous studies have shown increased complement activation in normal and preeclamptic pregnancies. We aimed to investigate the role of the mannose-binding lectin pathway in the initiation of pathological complement activation
Dorottya Csuka +2 more
exaly +4 more sources
Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism [PDF]
Thrombosis Research, 2018 Deep vein thrombosis (DVT) originates in the valvular sinuses of large veins in a local milieu characterized by stasis and severe hypoxia. This may induce complement- and coagulation activation, which potentially increases the risk of venous thromboembolism (VTE).
Kristian Hindberg +2 more
exaly +4 more sources
Molecular Immunology, 2009
Paracoccidioides brasiliensis (Pb) is a dimorphic fungal pathogen that causes paracoccidioidomycosis, the most severe deep mycosis from South America. Although cell mediated immunity is considered the most efficient protective mechanism against Pb infection, mechanisms of innate immunity are poorly defined.
Renan G, Toledo +3 more
openaire +2 more sources
Paracoccidioides brasiliensis (Pb) is a dimorphic fungal pathogen that causes paracoccidioidomycosis, the most severe deep mycosis from South America. Although cell mediated immunity is considered the most efficient protective mechanism against Pb infection, mechanisms of innate immunity are poorly defined.
Renan G, Toledo +3 more
openaire +2 more sources
The mannose binding lectin pathway and early complement activation in (murine) abortion
Journal of Reproductive Immunology, 2010Introduction: Girardi and Salmon highlighted the role of complement in early gestation failures in mice. We wanted to identify the pathway of its early activation in the murine natural immune resorbtion model she used. Methods: We monitored the protein and mRNAs expression of MBL-A and C, C3, at different days of gestation, in the uteri of either an ...
Petitbarat, Marie +6 more
openaire +2 more sources
Biochimica Et Biophysica Acta - Proteins and Proteomics, 2012
The lectin pathway of the complement system is activated following the binding of carbohydrate-based ligands by recognition molecules such as mannose-binding lectin (MBL) or ficolins. Engagement of the recognition molecules causes activation of associated MBL-associated serine proteases or MASPs, which in turn activate downstream complement molecules ...
Renee C Duncan +2 more
exaly +3 more sources
The lectin pathway of the complement system is activated following the binding of carbohydrate-based ligands by recognition molecules such as mannose-binding lectin (MBL) or ficolins. Engagement of the recognition molecules causes activation of associated MBL-associated serine proteases or MASPs, which in turn activate downstream complement molecules ...
Renee C Duncan +2 more
exaly +3 more sources