Structural biology of complement receptors [PDF]
Frontiers in Immunology, 2023 The complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer.
Jorge Santos-López +4 more
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Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis [PDF]
Frontiers in Cell and Developmental Biology, 2021 The complement system is deeply embedded in our physiology and immunity. Complement activation generates a multitude of molecules that converge simultaneously on the opsonization of a target for phagocytosis and activation of the immune system via ...
Sofie Vandendriessche +3 more
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An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer [PDF]
Antibodies, 2021 The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptors ...
Fazrena Nadia Md Akhir +11 more
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Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes [PDF]
Acta Neuropathologica Communications, 2023 Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological manifestations.
Amer Toutonji +5 more
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Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity [PDF]
Frontiers in Immunology, 2020 Upon entry of human immunodeficiency virus 1 (HIV-1) into the host, innate immune mechanisms are acting as a first line of defense, that considerably also modify adaptive immunity by the provision of specific signals. Innate and adaptive immune responses
Wilfried Posch +4 more
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New insights for C5a and C5a receptors in sepsis [PDF]
Frontiers in Immunology, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Hongwei eGao, Chunguang eYan
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Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice [PDF]
mSphere, 2017 Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic cells (FDCs ...
Sarah J. Kane +8 more
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Structural Immunology of Complement Receptors 3 and 4 [PDF]
Frontiers in Immunology, 2018 Complement receptors (CR) 3 and 4 belong to the family of beta-2 (CD18) integrins. CR3 and CR4 are often co-expressed in the myeloid subsets of leukocytes, but they are also found in NK cells and activated T and B lymphocytes.
Thomas Vorup-Jensen +2 more
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RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment [PDF]
Cells, 2020 The phagocytic integrins and complement receptors αMβ2/CR3 and αXβ2/CR4 are classically associated with the phagocytosis of iC3b-opsonized particles.
Alvaro Torres-Gomez +8 more
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Alteration in Leukocyte Subsets and Expressions of FcγR and Complement Receptors among Female Ragpickers in Eastern India [PDF]
Safety and Health at Work, 2017 Background: There are a million ragpickers in India who gather and trade recyclable municipal solid wastes materials for a living. The objective of this study was to examine whether their occupation adversely affects their immunity. Methods: Seventy-four
Nandan K. Mondal +7 more
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