Results 1 to 10 of about 315,694 (161)
Structural biology of complement receptors. [PDF]
Front Immunol, 2023 The complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer. Complement receptors encompass at least eight proteins from four structural classes, orchestrating complement-mediated humoral and cellular ...
Santos-López J +3 more
europepmc +5 more sources
Complement Receptors in Inflammation [PDF]
, 2012 Complement was first discovered in 1889 as a bactericidal protein, distinct from heat stable antibodies present in normal serum. Since that time, it has been shown that the complement system is a biochemical cascade, comprised of more than 30 fluid phase and membraneassociated proteins, normally present as inactive forms.
Marianna Kulka, Priyanka Pundir
core +5 more sources
RECEPTORS FOR COMPLEMENT ON LEUKOCYTES [PDF]
The Journal of Experimental Medicine, 1968 Sheep red blood cells sensitized by 7S, but not by 19S rabbit anti-Forssman antibodies, adhere and form rosettes on mouse macrophages and on a few monocytes and polymorphonuclear cells (PMN). When, however, C' factors from mouse serum are added to the antigen-19S antibody complex (EAC'), rosettes are formed on most mouse peritoneal macrophages and PMN ...
Waltraut H. Lay, Victor Nussenzweig
openaire +2 more sources
Complement receptor is an inhibitor of the complement cascade. [PDF]
The Journal of experimental medicine, 1981 A glycoprotein from the membrane of human erythrocytes has been identified as a receptor for C3b (CR1). It promotes the dissociation of the alternative pathway C3 convertase C3b,Bb and the cleavage of C3b by C3b/C4b inactivator. We find that CR1 also inactivates the C3 and C5 convertases of the classical pathway.
Iida K, Nussenzweig
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Effects of immobilized immune complexes on Fc- and complement-receptor function in resident and thioglycollate-elicited mouse peritoneal macrophages [PDF]
, 1979 We have examined the Fc- and complement-receptor function of resident and thioglycollate-elicited mouse peritoneal macrophages plated on surfaces coated with rabbit antibody-antigen complexes and with complement.
Michl, Josef +3 more
core +4 more sources
Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]
, 2018 Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena +5 more
core +2 more sources
CR3 is the dominant phagocytotic complement receptor on human dendritic cells. [PDF]
, 2013 Dendritic cells (DCs) play a decisive role in immunity; they interact with various pathogens via several pattern recognition and different opsonophagocytotic receptors, including Fc- and complement-receptors. beta2-integrins, including complement
Abram +56 more
core +1 more source
New insights for C5a and C5a receptors in sepsis [PDF]
, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Gao, Hongwei, Yan, Chunguang
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Journal of Investigative Dermatology, 1990 CR2, a membrane glycoprotein, is one of a number of cell-surface proteins which bind activation and processing fragments of the complement system. CR2, which is found on normal B lymphocytes, follicular dendritic cells in lymphoid organs, and epithelial cells, interacts preferentially with C3dg, the terminal activation/processing fragment of the third ...
B M Bradt +3 more
openaire +3 more sources
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]
, 1984 A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings +9 more
core +1 more source