Results 101 to 110 of about 173,706 (280)
BMC Research Notes, 2009 Background Borreliae employ multiple immune evasive strategies such as binding to complement regulatory proteins [factor H (fH) and factor H like-1 (FHL1)], differential regulation of surface membrane proteins, antigenic variation, and binding of ...
Gil Horacio +5 more
doaj +1 more source
Immunohistochemical localization of complement regulatory proteins in the human retina.
Histology and histopathology, 2012 Age-related macular degeneration (AMD) is a complex disease. Genetic studies have found strong associations between AMD and variants of several complement pathway-associated genes. The regulation of the complement cascade seems to be critical in the pathogenesis of AMD. In 45 human donor eyes immunohistochemistry was performed using antibodies directed
Fett, Anna L. +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Chandipura virus evades human complement by recruiting host complement regulatory proteins
International Journal of Infectious Diseases, 2020 U. Kunnakkadan, J. Bernet Johnson
doaj +1 more source
Advances in HematologyTransfusion-dependent thalassemia (TDT) is characterized by chronic hemolysis, ineffective erythropoiesis, and iron overload, resulting in persistent oxidative stress and systemic inflammation.
Afshan Sumera +3 more
doaj +1 more source
Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway
Frontiers in Microbiology, 2017 The complement system is a crucial defensive network that protects the host against invading pathogens. It is part of the innate immune system and can be initiated via three pathways: the lectin, classical and alternative activation pathway.
Anne Rosbjerg +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Principal component analysis (PCA) was performed to show the distribution of data from the combination of three groups Ss+DM+ (blue circles), and Ss-DM+ (maroon circles). The PCA represents the two principal components of variation.
Saravanan Munisankar (842971) +8 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source