Results 111 to 120 of about 305,759 (329)

Chimerism and xenotransplantation: New concepts [PDF]

, 1999
In both transplant and infectious circumstances, the immune response is governed by migration and localization of the antigen. If the antigenic epitopes of transgenic xenografts are sufficiently altered to avoid evoking the destructive force of innate ...
Demetris, AJ, Fung, JJ, Murase, N, Rao, AS, Starzl, TE, Thomson, A   +5 more
core   +1 more source

Complement and complement regulatory proteins in human tears.

Investigative ophthalmology & visual science, 1997
The complement system is part of the innate defense system of the body, and it contributes to inflammatory conditions. The current study examined tears for the presence of complement components, the activity of the components, and the presence of regulatory components.The significance of a functional complement system in tears was examined in four ways.
M D, Willcox, C A, Morris, A, Thakur, R A, Sack, J, Wickson, W, Boey   +5 more
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study.

PLoS Neglected Tropical Diseases
BackgroundNumerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement
Anuradha Rajamanickam, Bindu Dasan, Saravanan Munisankar, Sujatha Nott, Pradeep A Menon, Fayaz Ahamed Shaik, Ponnuraja Chinnaiyan, Thomas B Nutman, Subash Babu   +8 more
doaj   +1 more source

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]

, 2019
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P, Barlow, Paul N, Cook, H. T, Cooke, Katie, Denton, Harriet, Kavanagh, David, Liszewski, M. K, Marchbank, Kevin J, Pappworth, Isabel Y, Pickering, Matthew C, Smith-Jackson, Kate, Yang, Yi   +11 more
core   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli [PDF]

, 2014
Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America.
A Buschiazzo, AC Frasch, AC Ivens, AL Price, Alexandra Gerber, Ana Tereza Ribeiro de Vasconcelos, Arnaldo Zaha, B Li, B Roure, Björn Andersson, C Biemont, C Folgueira, CA Buscaglia, CA Buscaglia, Carlos Talavera-Lopez, CB Lira, CB Toaldo, CE Butler, Claudia Elizabeth Thompson, CP Pena, CS Peacock, D Bahia, D Bahia, D Cosentino-Gomes, D Ekanayake, D Horn, D Miranda-Saavedra, D Salmon, DA Largaespada, DA Urrea, DA Urrea, Daniella Castanheira Bartholomeu, DC Bartholomeu, DG Passos-Silva, Diana Bahia, DM Martin, Débora Denardin Lückemeyer, E Ghedin, EC Grisard, EC Grisard, Edmundo Carlos Grisard, EJ Tobie, EL Raven, Elgion Loreto, Elisa Beatriz Prestes, F Corpet, F Guhl, F Guhl, F Maia Da Silva, F Maia da Silva, F Maia da Silva, F Sievers, FB Nogueira, Fábio Mitsuo Lima, G Benson, G Wagner, GA Vallejo, GA Vallejo, GA Vallejo, Gabriela Rodrigues-Luiz, Glauber Wagner, Gustavo Adolfo Vallejo, H Castro, H Diez, H Diez, H Diez, H Ngo, H Shi, H Shi, HA Schmidt, HG van Luenen, HS Kim, I Kamileri, I Romero, J Baum, J Fonager, J Henriksson, J Jurka, JD Damasceno, JE Vasquez, Jessica C. Kissinger, JF Turrens, JH Lee, JL Affranchino, JL Parsons, José Franco da Silveira Filho, JV Bannister, K Ersfeld, K Strimmer, KA Norris, Karina Mariante Monteiro, Kevin Morris Tyler, KL Patrick, L Piacenza, L Piacenza, LF Lye, LG Almeida, LJ Cliffe, LM Freitas, Luiz Gonzaga Paula de Almeida, M Berriman, M Cabrine-Santos, M Cabrine-Santos, M Schramp, M Steindel, MA Chiurillo, MA de Sousa, Mauro Freitas Ortiz, MB Rogers, MC Elias, MC Motta, MD Pineyro, MF Amaya, MH de Moraes, MH Saier Jr, MI Cano, Miguel Angel Chiurillo, Milene Höehr de Moraes, MJ Fraser Jr, MJ Schofield, MM Kangussu-Marcolino, MP Wymann, MR Briones, MR Garcia Silva, MT Tammi, Mário Steindel, N Anez-Rojas, N Añez, N Inoue, N Saitou, NM El-Sayed, NM El-Sayed, O Franzen, O Franzen, Oberdan de Lima Cunha, P Luciano, Patrícia Hermes Stoco, R Bosotti, R Marone, RD Page, RL Barnes, Rondon Mendonça-Neto, Rosane Silva, RR Moraes Barros, RT Souza, S Cestari Idos, S Kumar, S Martinez-Calvillo, S Muller, S Schenkman, Santuza Maria Ribeiro Teixeira, SF Altschul, Silvane Maria Fonseca Murta, SJ Westenberger, SL dos Santos, SM Teixeira, SR Wilkinson, SR Wilkinson, SR Wilkinson, SS Dc-Rubin, Sérgio Schenkman, T Downing, TA Minning, TA Pitcovsky, Thais Cristine Marques Sincero, Tiago Antonio de Oliveira Mendes, Turán Peter Urmenyi, Viviane Grazielle Silva, Wanderson Duarte DaRocha, WD DaRocha, X Huang, ZC Caballero, Álvaro José Romanha   +172 more
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human

BMC Research Notes, 2009
Background Borreliae employ multiple immune evasive strategies such as binding to complement regulatory proteins [factor H (fH) and factor H like-1 (FHL1)], differential regulation of surface membrane proteins, antigenic variation, and binding of ...
Gil Horacio, Camafeita Emilio, Escudero Raquel, Bhide Mangesh R, Jado Isabel, Anda Pedro   +5 more
doaj   +1 more source