Results 31 to 40 of about 140,468 (298)

Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host

Frontiers in Microbiology, 2019
Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao, Ximeng Sun, Yi Chen, Bin Zhan, Xinping Zhu   +4 more
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Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein [PDF]

Journal of Virology, 2005
ABSTRACTVaccinia virus encodes a homolog of the human complement regulators named vaccinia virus complement control protein (VCP). It is composed of four contiguous complement control protein (CCP) domains. Previously, VCP has been shown to bind to C3b and C4b and to inactivate the classical and alternative pathway C3 convertases by accelerating the ...
Jayati Mullick, Yogesh Panse, Akhilesh Kumar Singh, Sharanabasava Hallihosur, John Bernet, Arvind Sahu   +5 more
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Involvement of the complement system in immune thrombocytopenia: review of the literature

Immunological Medicine, 2023
Immune thrombocytopenia (ITP) is a thrombocytopenic condition induced by autoimmune mechanisms and includes secondary ITP with underlying diseases such as connective tissue diseases (CTD).
Risa Shindo, Ryohei Abe, Kenji Oku, Tomoki Tanaka, Yu Matsueda, Tatsuhiko Wada, Yoshiyuki Arinuma, Sumiaki Tanaka, Tatsuyoshi Ikenoue, Yoshitaka Miyakawa, Kunihiro Yamaoka   +10 more
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On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni. [PDF]

PLoS Neglected Tropical Diseases, 2013
It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor of the complement system membrane attack complex, were identified in the
Leonardo P Farias, Greice Krautz-Peterson, Cibele A Tararam, Bogar O Araujo-Montoya, Tatiana R Fraga, Henrique K Rofatto, Floriano P Silva, Lourdes Isaac, Akram A Da'dara, R Alan Wilson, Charles B Shoemaker, Luciana C C Leite   +11 more
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Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation

Frontiers in Immunology, 2022
Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma.
Alexandra Gerogianni, Alexandra Gerogianni, Jordan D. Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Satheesh Chonat, Kerstin Sandholm, Karin E. McAdam, Kristina N. Ekdahl, Kristina N. Ekdahl, Kristina N. Ekdahl, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Camilla Mohlin, Camilla Mohlin, Lubka T. Roumenina, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson   +20 more
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Complement Regulatory Proteins [PDF]

Journal of the American Society of Nephrology, 2003
In this issue of JASN , Turnberg et al. ([1][1]) report that the manifestations of disease in an immune complex-mediated glomerulonephritis model are exacerbated in Cd59a knockout mice. Exacerbation was associated with an increase in C9 deposition in glomeruli, suggesting that the deficiency ...
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Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants

Journal of Translational Medicine, 2020
Background Complement Regulatory Proteins (CRPs), especially CD55 primarily negate complement factor 3-mediated injuries and maintain tissue homeostasis during complement cascade activation.
Mohammad Afzal Khan, Talal Shamma, Shadab Kazmi, Abdullah Altuhami, Hala Abdalrahman Ahmed, Abdullah Mohammed Assiri, Dieter Clemens Broering   +6 more
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Is It Possible to Intervene in the Capacity of Trypanosoma cruzi to Elicit and Evade the Complement System?

Frontiers in Immunology, 2021
Chagas’ disease is a zoonotic parasitic ailment now affecting more than 6 million people, mainly in Latin America. Its agent, the protozoan Trypanosoma cruzi, is primarily transmitted by endemic hematophagous triatomine insects.
Galia Ramírez-Toloza, Lorena Aguilar-Guzmán, Carolina Valck, Smrithi S. Menon, Viviana P. Ferreira, Arturo Ferreira   +5 more
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Complement regulatory proteins and autoimmunity

Autoimmunity, 2006
The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for disposing apoptotic cellular ...
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Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia

Platelets, 2017
In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger, Beate Eichelberger, Anja Ulz, Simon Panzer   +3 more
doaj   +1 more source