Results 31 to 40 of about 305,892 (307)
Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
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Complement Regulatory Proteins [PDF]
Journal of the American Society of Nephrology, 2003 In this issue of JASN , Turnberg et al. ([1][1]) report that the manifestations of disease in an immune complex-mediated glomerulonephritis model are exacerbated in Cd59a knockout mice. Exacerbation was associated with an increase in C9 deposition in glomeruli, suggesting that the deficiency ...
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Laboratory tests for disorders of complement and complement regulatory proteins [PDF]
American Journal of Hematology, 2015 The complement pathway is a cascade of proteases that is involved in immune surveillance and innate immunity, as well as adaptive immunity. Dysfunction of the complement cascade may be mediated by aberrations in the pathways of activation, complement regulatory proteins, or complement deficiencies, and has been linked to a number of hematologic ...
Angela R, Shih, Mandakolathur R, Murali
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An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice [PDF]
, 2005 Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six
Buxton, RS +8 more
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Atypical hemolytic uremic syndrome : update on the complement system and what is new [PDF]
, 2010 Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and predominant renal impairment. It is characterized by the absence of Shiga toxin-producing bacteria as a triggering factor.
Dickenmann, Michael +2 more
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Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein [PDF]
Journal of Virology, 2005 ABSTRACTVaccinia virus encodes a homolog of the human complement regulators named vaccinia virus complement control protein (VCP). It is composed of four contiguous complement control protein (CCP) domains. Previously, VCP has been shown to bind to C3b and C4b and to inactivate the classical and alternative pathway C3 convertases by accelerating the ...
Jayati, Mullick +5 more
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Frontiers in Molecular Neuroscience, 2021 Complement, a feature of the innate immune system that targets pathogens for phagocytic clearance and promotes inflammation, is tightly regulated to prevent damage to host tissue.
Nicholas Peoples, Candace Strang
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Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host
Frontiers in Microbiology, 2019 Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao +4 more
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CD59 (CD59 molecule, complement regulatory protein) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on CD59 (CD59 molecule, complement regulatory protein), with data on DNA, on the protein encoded, and where the gene is implicated.
Donev, RM, Kolev, MV
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Profiling Complement System Components in Primary CNS Vasculitis
Cells, 2021 Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji +6 more
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