Results 191 to 200 of about 599,243 (259)

The life-and-death struggle between the complement system and pathogens: Mechanisms of elimination, evasion tactics, and translational potential. [PDF]

Virulence
Lian S, Liu J, Yang Y, Zhu G, Xia P.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Differential Recognition of Lipopolysaccharide O-Antigens by the Pattern Recognition Molecules MBL and Ficolins of the Complement System. [PDF]

J Innate Immun
Hymøller KM, Crone L, Thiel S, Hennet T.   +3 more
europepmc   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Reduced retinal microvascular density in patients with mixed connective tissue disease: an exploratory pilot study on the interplay between aging, renal function, and complement system. [PDF]

Front Immunol
Triggianese P, Capparelli E, D'Antonio A, Nesi C, Lombardo M, Kroegler B, Bergamini A, Mancino R, Mitterhofer AP, Della-Morte D, Nucci C, Cesareo M, Martucci A.   +12 more
europepmc   +1 more source

Inflammation-Driven Plaque Erosion in Atherosclerosis: A Focus on Complement System Pathways. [PDF]

Curr Atheroscler Rep
Ramoni D, Carbone F, Kraler S, Di Vece D, Montecucco F, Liberale L.   +5 more
europepmc   +1 more source

Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT. [PDF]

RMD Open
Mistegaard C, Troldborg A, Torgutalp M, Loft AG, Thiel S, Muche B, Rios Rodriguez V, Protopopov M, Listing J, Sieper J, Poddubnyy D, Proft F.   +11 more
europepmc   +1 more source

Genetic susceptibility to cerebral palsy involves complement system-mediated neuronal development and plasticity pathway. [PDF]

Sci Rep
Kun H, Zhou Q, Wu H, Yang D, Xiong C, Zhang X.   +5 more
europepmc   +1 more source

The Function of Transforming Growth Factor 2 in Facilitating Inflammasome Activation to Enhance the Development of Myopia via Complement System. [PDF]

Cells
Lin SC, Hsu YA, Lin CF, Chen CS, Tien PT, Wang YC, Chang CY, Lin ES, Chen JJ, Wu MY, Lin HJ, Wan L.   +11 more
europepmc   +1 more source

New insights into the role of complement system in colorectal cancer (Review). [PDF]

Mol Med Rep
Xu Y, Zhou J, Wu Y, Shen J, Fu X, Liu M, Liang S.   +6 more
europepmc   +1 more source