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JPMA. The Journal of the Pakistan Medical Association, 1976 Some of the next articles are maybe not open access.
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Evolution of the complement system
Current Opinion in Immunology, 2001The mammalian complement system constitutes a highly sophisticated body defense machinery comprising more than 30 components. Research into the evolutionary origin of the complement system has identified a primitive version composed of the central component C3 and two activation proteases Bf and MASP in cnidaria.
Masaru, Nonaka, Fumiko, Yoshizaki
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The complement system and systemic sclerosis
Immunologic Research, 1993Serum concentrations of the various complement components including the classical and the alternative pathways were determined in 58 control healthy subjects and 80 patients with systemic sclerosis (SSC). The mean concentrations of C1q, C2, C5, C6, C7, C9, and factor B were significantly increased in the SSC patients in comparison to controls, while ...
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Pathways to the Complement System
New England Journal of Medicine, 1972IT has been well appreciated for many years that the serum complement system, through the concerted action of all its components, is a prime mediator of cytotoxic injury to antibody-sensitized cell...
I H, Lepow, F S, Rosen
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Proteases of the complement system
Biochemical Society Transactions, 2004The complement system is a group of about 35 soluble and cell-surface proteins which interact to recognize, opsonize and clear or kill invading micro-organisms or altered host cells (e.g. apoptotic or necrotic cells). Complement is a major part of the innate immune system.
R B, Sim, S A, Tsiftsoglou
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The Complement System in Uremia
Scandinavian Journal of Urology and Nephrology, 1980Plasma C1q, C1 esterase inactivator, C4, C3 and C3 proactivator were measured in 20 chronic uremic patients on maintenance hemodialysis, in 10 conservatively treated chronic uremic patients and in 20 healthy volunteers. There was no statistical significant difference between the patient groups in any of the measured complement components.
K A, Jørgensen, E, Stoffersen
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The complement system in teleosts
Fish & Shellfish Immunology, 2002Complement, an important component of the innate immune system, is comprised of about 35 individual proteins. In mammals, activation of complement results in the generation of activated protein fragments that play a role in microbial killing, phagocytosis, inflammatory reactions, immune complex clearance, and antibody production. Fish appear to possess
M Claire H, Holland, John D, Lambris
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Complement system in zebrafish
Developmental & Comparative Immunology, 2014Zebrafish is recently emerging as a model species for the study of immunology and human diseases. Complement system is the humoral backbone of the innate immune defense, and our knowledge as such in zebrafish has dramatically increased in the recent years. This review summarizes the current research progress of zebrafish complement system.
Shicui, Zhang, Pengfei, Cui
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The complement system in atherosclerosis
Atherosclerosis, 1988Complement is a term referring to a collection of plasma proteins, specific cellular receptors and cell surface regulatory molecules. Activation of the complement system to completion results in the formation of C5b-9 terminal complexes. These complexes have been observed in human atherosclerotic lesions by immunohistochemistry.
P S, Seifert, M D, Kazatchkine
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Introduction to the complement system
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1984Abstract Complement is the essential effector mechanism in humoral immunity to infection. Combination of antibody with antigen causes cross-linking, leading to precipitation of soluble antigens and agglutination of particular antigens, but no more.
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