Complement system - Open Access .click

Current Opinion in Nephrology and Hypertension, 1999
Interest has blossomed in the development of complement inhibitors, in parallel with a growth in our understanding of the biology of the complement cascade. The first generation of designed inhibitors was based on naturally occurring complement receptors and regulatory molecules.
J E, Marsh, J R, Pratt, S H, Sacks
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Complement system in zebrafish

Developmental & Comparative Immunology, 2014
Zebrafish is recently emerging as a model species for the study of immunology and human diseases. Complement system is the humoral backbone of the innate immune defense, and our knowledge as such in zebrafish has dramatically increased in the recent years. This review summarizes the current research progress of zebrafish complement system.
Shicui, Zhang, Pengfei, Cui
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Evolution of the complement system

Current Opinion in Immunology, 2001
The mammalian complement system constitutes a highly sophisticated body defense machinery comprising more than 30 components. Research into the evolutionary origin of the complement system has identified a primitive version composed of the central component C3 and two activation proteases Bf and MASP in cnidaria.
Masaru, Nonaka, Fumiko, Yoshizaki
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The complement system and systemic sclerosis

Immunologic Research, 1993
Serum concentrations of the various complement components including the classical and the alternative pathways were determined in 58 control healthy subjects and 80 patients with systemic sclerosis (SSC). The mean concentrations of C1q, C2, C5, C6, C7, C9, and factor B were significantly increased in the SSC patients in comparison to controls, while ...
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