The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis.
Peter A. Ward, J. Vidya Sarma
openaire +4 more sources
Complement activation and protein adsorption by carbon nanotubes [PDF]
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel+5 more
core +2 more sources
Detection and characterisation of Complement protein activity in bovine milk by bactericidal sequestration assay [PDF]
Susan Maye is in receipt of a Teagasc Walsh Fellowship. Financial support by the Department of Agriculture, Food and the Marine is gratefully acknowledged.Copyright © Proprietors of Journal of Dairy Research 2015 (Institute of Food Research and the ...
Fitzgerald, Gerald F+3 more
core +1 more source
Complement System Part I – Molecular Mechanisms of Activation and Regulation
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
N. Merle+3 more
semanticscholar +1 more source
Complement System in Brain Architecture and Neurodevelopmental Disorders
Current evidence indicates that certain immune molecules such as components of the complement system are directly involved in neurobiological processes related to brain development, including neurogenesis, neuronal migration, synaptic remodeling, and ...
J. Magdalon+5 more
semanticscholar +1 more source
Quantitative multiplex profiling of the complement system to diagnose complement‐mediated diseases
Objectives Complement deficiencies are difficult to diagnose because of the variability of symptoms and the complexity of the diagnostic process. Here, we applied a novel ‘complementomics’ approach to study the impact of various complement deficiencies ...
Esther Willems+23 more
doaj +1 more source
The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J+4 more
core +1 more source
The good, the bad, and the opportunities of the complement system in neurodegenerative disease
The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit of the inflammatory immune response.
Nicole D. Schartz, A. Tenner
semanticscholar +1 more source
Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena+5 more
core +2 more sources
Hyperbolic Structures and Root Systems [PDF]
We discuss the construction of a one parameter family of complex hyperbolic structures on the complement of a toric mirror arrangement associated with a simply laced root system.
Dijk, G. van+2 more
core +10 more sources