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The complement system

open access: yesCell and Tissue Research, 2010
The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis.
Peter A. Ward, J. Vidya Sarma
openaire   +4 more sources

Complement activation and protein adsorption by carbon nanotubes [PDF]

open access: yes, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel   +5 more
core   +2 more sources

Detection and characterisation of Complement protein activity in bovine milk by bactericidal sequestration assay [PDF]

open access: yes, 2015
Susan Maye is in receipt of a Teagasc Walsh Fellowship. Financial support by the Department of Agriculture, Food and the Marine is gratefully acknowledged.Copyright © Proprietors of Journal of Dairy Research 2015 (Institute of Food Research and the ...
Fitzgerald, Gerald F   +3 more
core   +1 more source

Complement System Part I – Molecular Mechanisms of Activation and Regulation

open access: yesFrontiers in Immunology, 2015
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
N. Merle   +3 more
semanticscholar   +1 more source

Complement System in Brain Architecture and Neurodevelopmental Disorders

open access: yesFrontiers in Neuroscience, 2020
Current evidence indicates that certain immune molecules such as components of the complement system are directly involved in neurobiological processes related to brain development, including neurogenesis, neuronal migration, synaptic remodeling, and ...
J. Magdalon   +5 more
semanticscholar   +1 more source

Quantitative multiplex profiling of the complement system to diagnose complement‐mediated diseases

open access: yesClinical & Translational Immunology, 2020
Objectives Complement deficiencies are difficult to diagnose because of the variability of symptoms and the complexity of the diagnostic process. Here, we applied a novel ‘complementomics’ approach to study the impact of various complement deficiencies ...
Esther Willems   +23 more
doaj   +1 more source

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

open access: yes, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J   +4 more
core   +1 more source

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

open access: yesJournal of Neuroinflammation, 2020
The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit of the inflammatory immune response.
Nicole D. Schartz, A. Tenner
semanticscholar   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

open access: yes, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena   +5 more
core   +2 more sources

Hyperbolic Structures and Root Systems [PDF]

open access: yes, 2010
We discuss the construction of a one parameter family of complex hyperbolic structures on the complement of a toric mirror arrangement associated with a simply laced root system.
Dijk, G. van   +2 more
core   +10 more sources

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