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Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury. [PDF]

open access: yesSignal Transduct Target Ther
Mallah K   +12 more
europepmc   +1 more source

Uncovering Proteomic and Biochemical Alterations in Plasma from Lesch-Nyhan Disease Patients. [PDF]

open access: yesCell Mol Neurobiol
Javed S   +8 more
europepmc   +1 more source
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Evasion of the complement system by Leishmania through the uptake of factor H, a complement regulatory protein

Acta Tropica, 2021
Escaping the complement system is an important step in the establishment of infections. Some pathogens have acquired the ability to inactivate the complement system to ensure successful infection. This has been observed in parasites from the genus Leishmania, which inactivate C3b molecules deposited on their surface through the membrane protease GP63 ...
Adalberto Alves Pereira Filho   +9 more
openaire   +2 more sources

Protein-Protein Interaction in the α-Complementation System of β-Galactosidase

1992
Publisher Summary This chapter discusses protein–protein interaction in the α-complementation system of β-galactosidase. α-complementation system in β-galactosidase system is a system of protein–protein interaction where active enzyme is formed through the association of two different polypeptide chains encoded by different lacZ alleles.
J H, Zeilstra-Ryalls, R L, Somerville
openaire   +2 more sources

Leishmanial protein kinases phosphorylate components of the complement system.

The EMBO Journal, 1991
Externally oriented protein kinases are present on the plasma membrane of the human parasite, Leishmania. Since activation of complement plays an important role in the survival of these parasites, we examined the ability of protein kinases from Leishmania major to phosphorylate components of the human complement system. The leishmanial protein kinase-1
T, Hermoso   +4 more
openaire   +2 more sources

Purification of a lamprey complement protein homologous to the third component of the mammalian complement system.

The Journal of Immunology, 1984
Abstract A lamprey protein homologous to the third component of mammalian complement was isolated from lamprey plasma and was tentatively designated lamprey C3. Lamprey C3 is a major protein in lamprey serum with electrophoretic mobility of beta-globulin and with m.w. of 190,000.
M, Nonaka   +6 more
openaire   +2 more sources

The function of the proteins in the complement system

Trends in Biochemical Sciences, 1976
Abstract The proteins which constitute the complement system are normal components in the fluid portion of blood and other fluids of man and lower animals. Activation of these proteins via two major pathways results in a number of biologically significant activities which may be beneficial or detrimental to the host.
openaire   +1 more source

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