Results 211 to 220 of about 25,858 (250)
Identification and validation of genes encoding humoral specificity for the chemical allergen toluene diisocyanate. [PDF]
PLoS OneWisnewski AV, Liu J.
europepmc +1 more source
Adaptive Disorder as the Hallmark of Nanobodies Antigen-Binding Loops. [PDF]
J Chem Inf ModelBagordo D +4 more
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Viral Immunology
Cytomegalovirus (CMV) has long been thought to have an association with glioblastoma multiforme (GBM), although the exact role of CMV and any subsequent implications for treatment have yet to be fully understood. This study addressed whether IGH complementarity determining region-3 (CDR3)-CMV protein chemical complementarity, with IGH CDR3s ...
Andrea Chobrutskiy +2 more
exaly +3 more sources
Cytomegalovirus (CMV) has long been thought to have an association with glioblastoma multiforme (GBM), although the exact role of CMV and any subsequent implications for treatment have yet to be fully understood. This study addressed whether IGH complementarity determining region-3 (CDR3)-CMV protein chemical complementarity, with IGH CDR3s ...
Andrea Chobrutskiy +2 more
exaly +3 more sources
Journal of Immunology, 1999
Abstract Due to the greater range of lengths available to the third complementarity determining region of the heavy chain (HCDR3), the Ab repertoire of normal adults includes larger Ag binding site structures than those seen in first and second trimester fetal tissues.
F E Bertrand +2 more
exaly +3 more sources
Abstract Due to the greater range of lengths available to the third complementarity determining region of the heavy chain (HCDR3), the Ab repertoire of normal adults includes larger Ag binding site structures than those seen in first and second trimester fetal tissues.
F E Bertrand +2 more
exaly +3 more sources
Amyloid, 2023
Abstract Immunoglobulin light chain (LC) amyloidosis is a life-threatening disease whose understanding and treatment is complicated by vast numbers of patient-specific mutations. To address molecular origins of the disease, we explored 14 patient-derived and engineered proteins related to κ1-family germline genes ...
Elena S. Klimtchuk +5 more
openaire +3 more sources
Abstract Immunoglobulin light chain (LC) amyloidosis is a life-threatening disease whose understanding and treatment is complicated by vast numbers of patient-specific mutations. To address molecular origins of the disease, we explored 14 patient-derived and engineered proteins related to κ1-family germline genes ...
Elena S. Klimtchuk +5 more
openaire +3 more sources
Molecular Immunology, 2011
TCR diversity depends mainly on the hypervariable complementarity determining region 3 (CDR3) α and β loops generated by non-germline-encoded nucleotide insertions and/or deletions. It is known that the length of the CDR3β sequence shortens during the process of thymocyte development and that the extent of this shortening is strongly affected by ...
Takaji, Matsutani +6 more
openaire +3 more sources
TCR diversity depends mainly on the hypervariable complementarity determining region 3 (CDR3) α and β loops generated by non-germline-encoded nucleotide insertions and/or deletions. It is known that the length of the CDR3β sequence shortens during the process of thymocyte development and that the extent of this shortening is strongly affected by ...
Takaji, Matsutani +6 more
openaire +3 more sources
Biochemistry, 1999
The recombinant anti-ssDNA Fab, DNA-1, and 16 heavy chain complementarity determining region 3 (HCDR3) mutant variants were selected for thermodynamic characterization of ssDNA binding. The affinity of Fab to (dT)(15) under different temperatures and cation concentrations was measured by equilibrium fluorescence quenching titration.
A A, Komissarov, S L, Deutscher
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The recombinant anti-ssDNA Fab, DNA-1, and 16 heavy chain complementarity determining region 3 (HCDR3) mutant variants were selected for thermodynamic characterization of ssDNA binding. The affinity of Fab to (dT)(15) under different temperatures and cation concentrations was measured by equilibrium fluorescence quenching titration.
A A, Komissarov, S L, Deutscher
openaire +2 more sources
Journal of Molecular Biology, 2005
Anti-DNA antibodies play important roles in the pathogenesis of autoimmune diseases. They also represent a unique and relatively unexplored class of DNA-binding protein. Here, we present a study of conformational changes induced by DNA binding to an anti-ssDNA Fab known as DNA-1.
Jonathan P, Schuermann +4 more
openaire +2 more sources
Anti-DNA antibodies play important roles in the pathogenesis of autoimmune diseases. They also represent a unique and relatively unexplored class of DNA-binding protein. Here, we present a study of conformational changes induced by DNA binding to an anti-ssDNA Fab known as DNA-1.
Jonathan P, Schuermann +4 more
openaire +2 more sources