Results 121 to 130 of about 11,278 (212)

Epigenetic regulation of Mash1 expression [PDF]

, 2010
Mash1 is a proneural gene important for specifying the neural fate. The Mash1 locus undergoes specific epigenetic changes in ES cells following neural induction.
Beretta, Chiara, Beretta, Chiara
core   +1 more source

Complexin 2 regulates secretion of immunoglobulin in antibody‐secreting cells

Immunity, Inflammation and Disease, 2019
Introduction Complexins (CPLXs), initially identified in neuronal presynaptic terminals, are cytoplasmic proteins that interact with the soluble N‐ethylmaleimide‐sensitive factor attachment protein receptors (SNARE) complex to regulate the fusion of ...
Emi Tsuru, Kohei Oryu, Ken Sawada, Makoto Nishihara, Masayuki Tsuda   +4 more
doaj   +1 more source

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells [PDF]

, 2018
Aims/hypothesis: The expression of several neuronal genes in pancreatic beta cells is due to the absence of the transcription factor repressor element 1 (RE-1) silencing transcription factor (REST). The identification of these traits and their functional
Abderrahmani, A., Allagnat, F., Caille, D., Chaffard, G., Fukuda, M., Haefliger, J.-A, Maechler, P., Martin, D., Meda, P., Regazzi, R., Waeber, G.   +10 more
core  

2012 Alaska's Construction Spending Forecast [PDF]

, 2012
The total value of construction spending “on the street” in Alaska in 2012 will be $7.7 billion, up 3% from 2011.1,2,3 Wage and salary employment in the construction industry will be stable at the same level as last year— 15,800.
Goldsmith, Oliver Scott, Killorin, Mary
core  

Complexity of Complexin [PDF]

Biophysical Journal, 2014
openaire   +1 more source

Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia–reperfusion injury in rats by targeting multiple cellular processes

Neuropsychiatric Disease and Treatment, 2017
Mingyang Wang,* Yi Zhang,* Lu Feng, Ji Zheng, Shujie Fan, Junya Liu, Nan Yang, Yanyong Liu, Pingping Zuo Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing ...
Wang M, Zhang Y, Feng L, Zheng J, Fan S, Liu J, Yang N, Liu Y, Zuo P   +8 more
doaj  

Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner [PDF]

, 2017
Background Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has
Benusa, S. D., DeVries, G. H., Dupree, J. L., George, N. M., Sword, B. A.   +4 more
core   +1 more source

GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis

Communications Biology
Essential tremor (ET) is a prevalent neurological disorder with a largely unknown underlying biology. In this genome-wide association study meta-analysis, comprising 16,480 ET cases and 1,936,173 controls from seven datasets, we identify 12 sequence ...
Astros Th. Skuladottir, Lilja Stefansdottir, Gisli H. Halldorsson, Olafur A. Stefansson, Anna Bjornsdottir, Palmi Jonsson, Vala Palmadottir, Thorgeir E. Thorgeirsson, G. Bragi Walters, Rosa S. Gisladottir, Gyda Bjornsdottir, Gudrun A. Jonsdottir, Patrick Sulem, Daniel F. Gudbjartsson, Kirk U. Knowlton, David A. Jones, Aigar Ottas, Estonian Biobank, Ole B. Pedersen, Maria Didriksen, Søren Brunak, Karina Banasik, Thomas Folkmann Hansen, Christian Erikstrup, DBDS Genomic Consortium, Jan Haavik, Ole A. Andreassen, David Rye, Jannicke Igland, Sisse Rye Ostrowski, Lili A. Milani, Lincoln D. Nadauld, Hreinn Stefansson, Kari Stefansson   +33 more
doaj   +1 more source

Complexin cross-links pre-fusion SNAREs into a zig-zag array: a structure-based model for complexin clamping

, 2011
Complexin prevents SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. To understand the mechanism for this inhibition, we determined the structure of complexin bound to a mimetic of a pre-fusion SNAREpin lacking the portion of the v-SNARE which zippers last to trigger fusion.
Kümmel, Daniel, Krishnakumar, Shyam S., Radoff, Daniel T., Li, Feng, Giraudo, Claudio G., Pincet, Frederic, Rothman, James E., Reinisch, Karin M.   +7 more
openaire   +1 more source

Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle. [PDF]

Proc Natl Acad Sci U S A, 2023
Bera M, Radhakrishnan A, Coleman J, K Sundaram RV, Ramakrishnan S, Pincet F, Rothman JE.   +6 more
europepmc   +1 more source