Results 51 to 60 of about 1,693,695 (274)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Computational Thinking in Solving Engineering Problems – A Conceptual Model
Asian Journal of Assessment in Teaching and Learning, 2021 Programming is an excellent approach to cultivating computational thinking (CT) skills lacking among current engineering undergraduate students. Although highly useful in teaching programming skills, physical, tangible programming tools available in the ...
Choon Hui Neo +4 more
doaj +1 more source
Artificial Immune Systems - Models, algorithms and applications [PDF]
, 2010 Copyright © 2010 Academic Research Publishing Agency.This article has been made available through the Brunel Open Access Publishing Fund.Artificial Immune Systems (AIS) are computational paradigms that belong to the computational intelligence family and ...
Abbod, MF, Al-Enezi, JR, Alsharhan, S
core
Introducing ‘Neuromorphic Computing and Engineering’
Neuromorphic Computing and Engineering, 2021 Abstract The standard nature of computing is currently being challenged by a range of problems that start to hinder technological progress. One of the strategies being proposed to address some of these problems is to develop novel brain-inspired processing methods and technologies, and apply them to a wide range of application ...
openaire +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Computational Fluid Mechanics Methods and Applications in Marine Engineering
Journal of Marine Science and Engineering, 2023 Ocean flows and their interactions with marine structures, vehicles, etc [...]
Peng Du +3 more
doaj +1 more source
Does choice of programming language affect student understanding of programming concepts in a first year engineering course? [PDF]
, 2015 Most undergraduate engineering curricula include computer programming to some degree,introducing a structured language such as C, or a computational system such as MATLAB, or both.
Gratiano, Stephanie M. +2 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Integrated Computational Materials Engineering of Fire-Resistant Steels
Materials & DesignWe explore a wide compositional space of low-carbon steel, containing 11 alloying elements, assess its feasibility for fire-resistant applications via modeling yield strength at elevated temperatures.
Alireza Zargaran +9 more
doaj +1 more source
Computational Study of Protein-Ligand Unbinding for Enzyme Engineering
Frontiers in Chemistry, 2019 The computational prediction of unbinding rate constants is presently an emerging topic in drug design. However, the importance of predicting kinetic rates is not restricted to pharmaceutical applications.
Sérgio M. Marques +5 more
doaj +1 more source