Results 41 to 50 of about 775,245 (298)
The Relationship between Addiction to Computer Games and Isolation of adolescents: A Case Study of Junior High School Students in Kashan in 1395 [PDF]
Taḥqīqāt-i Farhangī-i Īrān, 2019 Computer games are exciting entertainments for teens that are attractive due to their charm and enjoyment. Today, with the expansion of computer games, we witness various complications.
M. Niazi, E. Shafaei, Z. Hasanzadeh
doaj +1 more source
Self-transformation through game design [PDF]
, 2015 This paper presents the results of a pioneering, experimental study that tracked certain psychological and behavioural changes in a group of game designers during the development of their serious games.
Gualeni, Stefano +1 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Investigating Correlation between Playing Computer Games and Readership among K-8 Students: Case Study of Karaj City [PDF]
تحقیقات کتابداری و اطلاعرسانی دانشگاهی, 2011 Objective: The present paper studies the relationship between computer games with readership among K-8 students in Karaj City in 2010. Methodoloy: A survey method was employed using a self-constructed questionnaire.
L Sharifi, mahdi shaghaghi, S Sharifi
doaj
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Arts, 2018 This article argues that Wolfenstein: The New Colossus, a AAA First-Person Shooter, is not only politically themed, but presents in itself a critical engagement with the politics of its genre and its player base.
Hans-Joachim Backe
doaj +1 more source
Understanding Computer Role-Playing Games: A Genre Analysis Based on Gameplay Features in Combat Systems [PDF]
, 2013 A game genre as diverse as that of computer role-playing games is difficult to overview. This poses challenges or both developers and researchers to position their work clearly within the genre.
Björk, Staffan +1 more
core +3 more sources
Learning through play: an educational computer game to introduce radar fundamentals [PDF]
, 2015 The information exchange has evolved from traditional books to computers and Internet in a few years' time. Our current university students were born in this age: they learn and have fun with different methods as previous generations did.
Cuinas, Inigo +2 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source