Results 51 to 60 of about 5,268 (276)
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
Students’ understanding of the concept friction : Groupdiscussion in year 2 through Concept cartoons
, 2021 The study is based on action resarch where four Concept cartoons have been constructed through careful resarch into the structure of the concept. 16 year 2 students in groups of four participated in a survey with the aim of providing knowledge about how ...
Palmqvist, Mikaela
core
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Concept Cartoons: What Have We Learnt?
, 2020 Concept This article sets out the major developments in the nature and format of Concept Cartoons. It identifies some of the major implications for teaching and learning, including using them to promote cognitive conflict and argumentation, using them ...
Stuart Naylor, Brenda Keogh
core
Research on Education and Media, 2022 Ethnopedagogy is expressed as the information that a society uses in raising children, which develops from the roots of its past. According to ethnopedagogy, education begins in the family, not in school, and continues throughout life in the society. One
Akcan Emrullah, Bakir Kemal Faruk
doaj +1 more source
Using Cartoons to Enhance Engineering Course Concepts [PDF]
2018 ASEE Annual Conference & Exposition Proceedings, 2020 Cartoons, while often associated with a younger audience, can assist some college engineering students in making relatable connections to course concepts and breaking down barriers to understanding. Intermediate engineering courses such as Dynamics and Fluid Mechanics, typically taken sophomore and junior year, contain numerous essential ideas that ...
openaire +2 more sources
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Research in Science and Mathematics EducationTujuan - Penelitian ini bertujuan untuk menghasilkan e-LKPD IPA berbasis concept cartoon materi zat aditif dan adiktif yang layak digunakan dalam pembelajaran IPA serta teruji keterbacaan oleh peserta didik.
Seto Ari Wibowo +2 more
doaj +1 more source
Advanced Science, EarlyView.BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet +5 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma +10 more
wiley +1 more source